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2022

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Articles 871 - 900 of 1814

Full-Text Articles in Biology

Agricultural Practices And Nitrogen Cycling Microbes: The Impact Of Sustainable Farming Practices On Nutrient Movement In Indianapolis Urban Farms, Margaret Davis May 2022

Agricultural Practices And Nitrogen Cycling Microbes: The Impact Of Sustainable Farming Practices On Nutrient Movement In Indianapolis Urban Farms, Margaret Davis

Undergraduate Honors Thesis Collection

As population movement to urban centers and decreased availability of fresh foods becomes more common, the prevalence of food deserts is becoming far greater. Urban farming can potentially help address these issues by bringing healthy and fresh food sources directly to these areas that lack access to quality food. Urban farming is reliant on the implementation of sustainable practices, like the use of cover crops, to increase the amount of nutrients that are accessible to plants from the soil. Nitrogen is a vital nutrient but cannot be readily produced by plants, so it must be obtained by either an external …

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Size Regulation Within The Germline Of The Developing Egg Chamber, Zoe Gladd Herdman May 2022

Size Regulation Within The Germline Of The Developing Egg Chamber, Zoe Gladd Herdman

Undergraduate Honors Thesis Collection

The relationship between the size of a cell and the size of its intracellular structures must be precisely regulated for proper development and functioning of the mature organism; however, the mechanisms that establish and maintain this relationship are not known. Much of the work on organelle size scaling has focused on individual cells or organelles, with some looking at how size scaling is maintained during development. However, it is not known whether the size of multiple organelles is coordinately regulated, and how cell size and organelle size are regulated within a syncytium or group of connected cells. Because many cell …

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Using Community Science To Assess The Effect Of Wing Pattern And Weather On Butterfly Behavior, Abbigail Merrill May 2022

Using Community Science To Assess The Effect Of Wing Pattern And Weather On Butterfly Behavior, Abbigail Merrill

Animal Science Undergraduate Honors Theses

Signaling in insects is used as communication and for attraction of mates. The physical appearance of the insect as well as conditions such as weather can play a role in visual signaling, by influencing the wavelengths of light available, and subsequent signal detection. We do not know, however, whether signals butterflies present broadly correlate with how they behave. In this study, we looked at the wing patterns and behavior of butterflies in Northwest Arkansas over a 3.5-year period to assess the relationship between wing pattern, weather, and behavior. We used observational data collected by hundreds of University of Arkansas students …

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Targeting Prosthetic Joint Infections Using Modified Egcg Derivatives With Antibiotics, Kavneet Chahil May 2022

Targeting Prosthetic Joint Infections Using Modified Egcg Derivatives With Antibiotics, Kavneet Chahil

Theses, Dissertations and Culminating Projects

Prosthetic joint implantations have revolutionized orthopedic medicine by allowing individuals to regain physical function with minimal side effects. However, they are susceptible to post- surgical complications due to bacterial infections. Three significant bacteria that are responsible for the development of joint infections include Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa, which act by adhering to the prosthesis and form biofilms thus becoming antibiotic-resistant. It has been reported that green tea polyphenols, which are extracted from the leaves of the Camellia sinensis plant, have antibacterial, antioxidant, and anti- inflammatory properties. The purified, and modified epigallocatechin-3-gallate-stearate (EGCGS) and palmitoyl-epigallocatechin-3-gallate (P-EGCG) are more …

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Assessment Of The Asexual Reproductive Strategies Of The Invasive Clinging Jellyfish Gonionemus Vertens, Valin Jarred Booker May 2022

Assessment Of The Asexual Reproductive Strategies Of The Invasive Clinging Jellyfish Gonionemus Vertens, Valin Jarred Booker

Theses, Dissertations and Culminating Projects

Anthropogenic activities are dispersing organisms at higher rates and this dispersal leads to organisms having a higher chance at becoming invasive. The Clinging Jellyfish, Gonionemus vertens, was originally from the north Pacific Ocean, but was identified in New Jersey’s coastal waters in 2016. G. vertens undergo a complex life history with an asexual polyp stage and the sexual medusa stage. Little is known about their polyp stage, which shows multiple asexual reproductive strategies that can generate high densities of medusa. Asexual reproduction of polyps was observed in 2020 to assess the rate of clonal production. Cultured polyps can have several …

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Cas9 Grna And Homologous Recombinant Plasmid Integrate Inducible Ha-N-Icer In The Aavs1 Locus Of Sk-Mel-24 Cells, Douglas Job May 2022

Cas9 Grna And Homologous Recombinant Plasmid Integrate Inducible Ha-N-Icer In The Aavs1 Locus Of Sk-Mel-24 Cells, Douglas Job

Theses, Dissertations and Culminating Projects

Melanoma is one of the most aggressive forms of cancer and is prone to metastasis. Once melanoma metastasizes, it is difficult to treat as patients often become immune to MAPK inhibitors and other therapeutic agents. Small molecules, such as immune checkpoint inhibitors, have demonstrated success as an adjunct to melanoma treatment. As a small, 18kDa molecule with tumor suppressing properties, research using ICER continues to provide positive anti-tumor effects. ICER regulates cAMP-induced transcription as a powerful, dominant-negative transcriptional repressor. Recent research demonstrated that the fusion tag hemagglutinin (HA), when fused to ICER’s N-terminus, increased ICER’s half-life and apoptotic activity in …

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Turning Tadpoles: Effects Of Salinity And Lateralization On Hyla Versicolor Escape Behaviors, Victor Lopiccolo May 2022

Turning Tadpoles: Effects Of Salinity And Lateralization On Hyla Versicolor Escape Behaviors, Victor Lopiccolo

Theses, Dissertations and Culminating Projects

Road salt, which is used as a roadway deicer in the winter time, is a major contributor to the salinization of freshwater habitats. Amphibians are particularly vulnerable to the salinization of aquatic environments due to the reliance of many species on pond, lake, and stream habitat in their aquatic larval stage. This study examined how Northern Gray Treefrog (Hyla versicolor) tadpole behavior is affected by salinity in a multiple t-maze. Alternate turning is sequential turning in opposite directions. Alternating turns lead the animal further from the starting point, and are innate behaviors associated with foraging, exploration, and escape. A multiple …

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Spatial Distribution And Recruitment Of The Botrylloides Violaceus And Botryllus Schlosseri Tunicates In Barnegat Bay, New Jersey, Kaitlyn Maguire May 2022

Spatial Distribution And Recruitment Of The Botrylloides Violaceus And Botryllus Schlosseri Tunicates In Barnegat Bay, New Jersey, Kaitlyn Maguire

Theses, Dissertations and Culminating Projects

Botrylloides violaceus and Botryllus schlosseri, colonial ascidians, are known invasive species of the North American Atlantic coast. The tunicates take residence and grow on native eelgrass (Zostera marina) blades, potentially negatively affecting eelgrass growth rate by means of smothering which reduces the plants ability to photosynthesize. Zostera marina is an important habitat, food source, and an indicator of environmental health. Invasive tunicates can decrease the amount of light that eelgrass receives which in turn, decreases the rate of growth of eelgrass. In the summer months of 2021, the relationship and abundance between the invasive tunicates B. schlosseri and B. violaceus …

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Green Tea Polyphenols Egcg-S And P-Egcg Containing Formulations Effectively Inhibit Growth And Biofilm Formation Of Eskape Bacteria, Calvin William Taylor May 2022

Green Tea Polyphenols Egcg-S And P-Egcg Containing Formulations Effectively Inhibit Growth And Biofilm Formation Of Eskape Bacteria, Calvin William Taylor

Theses, Dissertations and Culminating Projects

The field of medical microbiology has prospered for decades, finding treatments and cures for a multitude of bacterial infections. While success has been found in certain areas, challenges have arisen along the way. One of those challenges being the group of bacteria known as ESKAPE. The ESKAPE bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) have developed their multidrug resistance through adaptation to excessive drug use or prescription, unnecessary antimicrobial utilization, and substandard pharmaceuticals. They are the major cause of nosocomial infections throughout the world. With the ever-growing concern of antibiotic resistance in treating …

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Evaluation Of Ranavirus Major Capsid Protein Gene Sequence Mutations In United States East Coast Frog And Tadpole Populations, Erin Marie Tyll May 2022

Evaluation Of Ranavirus Major Capsid Protein Gene Sequence Mutations In United States East Coast Frog And Tadpole Populations, Erin Marie Tyll

Theses, Dissertations and Culminating Projects

Infectious disease is a leading cause of death in ectothermic taxa including amphibians, reptiles, and bony fish. Frog Virus 3 (FV3) Ranavirus is a prominent pathogen that infects frog and tadpole populations with lethal consequences, especially for pre-metamorphosed individuals. Wood frogs (Lithobates sylvaticus) are particularly susceptible to FV3 infection and mortality events. Conservation of this animal is a critical effort for the maintenance of these ecologically significant animals. Amphibians contribute to the regulation of insect pest levels, energy transfer between aquatic and terrestrial habitats, algae community productivity and function, and vertebrate biomass. Understanding genetic variations of FV3 is crucial to …

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Isolation And Analysis Of Single-Stranded Dna Aptamers For The Detection Of Ranavirus, Stephanie Zapata May 2022

Isolation And Analysis Of Single-Stranded Dna Aptamers For The Detection Of Ranavirus, Stephanie Zapata

Theses, Dissertations and Culminating Projects

The current molecular diagnostic methods for detection of deadly pathogens within a population can be time consuming and expensive. When surveying a population for the presence of a disease, time is a valuable resource. Therefore, a rapid pathogen test to use in the field will allow for faster detection of disease that can lead to determining a course of action for conservation of a species. Ranavirus is a double-stranded DNA virus that can cause mass mortality events in amphibian, reptile and fish populations. The disease can have the potential to wipe out entire populations or species if not controlled, having …

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Bioinformatics Analysis Of The Transcriptomic Profiles Of Duchenne Muscular Dystrophy Patients / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Bianca Gonzalez May 2022

Bioinformatics Analysis Of The Transcriptomic Profiles Of Duchenne Muscular Dystrophy Patients / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Bianca Gonzalez

Legacy Theses & Dissertations (2009 - 2024)

Duchenne Muscular Dystrophy (DMD) is a muscle-wasting disease that primarily affects boys characterized by loss of the dystrophin gene. Dystrophin is necessary for proper muscle growth, muscles that lack dystrophin are more prone to damage. In this thesis, a bioinformatics approach was used to evaluate the transcriptomic profiles of two datasets obtained from DMD patients. The two datasets were analyzed separately, as well as combined to identify differentially expressed genes. The first dataset, GSE6011, has 23 DMD samples and 14 controls. The second, GSE38417, consists of 16 DMD samples and six controls. Differential gene expression of both datasets combined found …

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Translation Control Tunes Drosophila Oogenesis, Elliot T. Martin May 2022

Translation Control Tunes Drosophila Oogenesis, Elliot T. Martin

Legacy Theses & Dissertations (2009 - 2024)

The decision of a stem cell to either self-renew or differentiate is controlled by specific cellularpathways that can act at the level of transcription, translation, or post-translation. To study the regulation of these pathways in-vivo, I have used the female Drosophila germline as a model system. Each of the steps from germline stem cell (GSC) to egg require changes in cellular pathways. These changes can occur at the level of transcription, post-transciption, translation, or post-translation . Decades of research has elucidated many of the changes to gene that occur during oogenesis, however, many players in this process still remain mysterious. …

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Role Of H3k4 Methylation In Myogenesis, Regeneration, And Muscle Disease / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Hannah Emily Shippas May 2022

Role Of H3k4 Methylation In Myogenesis, Regeneration, And Muscle Disease / Narrative Competence And Cognitive Mapping As A Culturally Sustaining Pedagogy In The Education Of Emergent Bilinguals, Hannah Emily Shippas

Legacy Theses & Dissertations (2009 - 2024)

Muscles are a crucial part of an organism’s wellbeing, as defects in distinct types of muscles can be lethal. Our voluntary muscles, skeletal muscles, go through distinct regeneration phases before reaching maturity. With its own pool of stem cells, muscles have a large potential for regeneration. This potential has led scientists into looking closely at the steps that lead a muscle stem cell into muscle fiber, also known as myogenesis. As a muscle cell moves through myogenesis, genes are led to be turned on/off with different epigenetic mechanisms, one being histone modifications. A methylation modification on the 4th Lysine on …

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Exploring The Response To Arsenic Using Trna Modification Detection, Writer Mediated Protection And Codon Usage Analytics, Anwesha Sarkar May 2022

Exploring The Response To Arsenic Using Trna Modification Detection, Writer Mediated Protection And Codon Usage Analytics, Anwesha Sarkar

Legacy Theses & Dissertations (2009 - 2024)

Transfer ribonucleic acid (tRNA) is a non-coding RNA which interacts with the messenger RNA (mRNA) to facilitate protein synthesis. tRNA is also one of the most heavily modified RNAs with the collection of modifications, termed as the tRNA epitranscriptome, ranging from simple methylation to complex hypermodification catalyzed by RNA epitranscriptomic writers. Detecting tRNA modifications is an evolving field and the state-of-the-art technologies that include next generation sequencing and mass spectrometry of intact and derivatized RNAs is described in the chapter one. Liquid chromatography coupled with mass spectrometry has previously been used to show that arsenic promotes increases in the levels …

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Using Macroinvertebrates To Assess The Effects Of Nutrient Input Between The Nolichucky And Pigeon Rivers, Anna Grizzard May 2022

Using Macroinvertebrates To Assess The Effects Of Nutrient Input Between The Nolichucky And Pigeon Rivers, Anna Grizzard

Electronic Theses and Dissertations

Previous work found significant differences in growth rates of native mussels at locations downstream from the regulated Walter’s Dam and the out-of-service, free-flowing Davy Crockett Dam. The purpose of this study is to investigate differences within the macroinvertebrate communities related to factors driving the differences in mussel growth between rivers. Macroinvertebrate samples were collected following the Tennessee Department of Environment and Conservation protocol for SQKICK collection and analyzed using the Tennessee Macroinvertebrate Index (TMI). There were no significant differences in TMI scores between the downstream sites of the rivers, but there were significant increases in chlorophylla, dissolved oxygen, …

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Evidence That The Transcriptional Repressor Icer Is Regulated Via The N-End Rule For Ubiquitination, Angelo Cirinelli, Justin Wheelan, Christopher Grieg, Carlos A. Molina May 2022

Evidence That The Transcriptional Repressor Icer Is Regulated Via The N-End Rule For Ubiquitination, Angelo Cirinelli, Justin Wheelan, Christopher Grieg, Carlos A. Molina

Department of Biology Faculty Scholarship and Creative Works

ICER is a transcriptional repressor that is mono- or poly-ubiquitinated. This either causes ICER to be translocated from the nucleus, or degraded via the proteasome, respectively. In order to further studies the proteins involved in ICER regulation mass spectrometry analysis was performed to identify potential candidates. We identified twenty eight ICER-interacting proteins in human melanoma cells, Sk-Mel-24. In this study we focus on two proteins with potential roles in ICER proteasomal degradation in response to the N-end rule for ubiquitination: the N-alpha-acetyltransferase 15 (NAA15) and the E3 ubiquitin-protein ligase UBR4. Using an HA-tag on the N- or C-terminus of ICER …

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Vectors, Pathogens And Climate Change: How Will Human Health Be Affected?, Joseph T. Barry May 2022

Vectors, Pathogens And Climate Change: How Will Human Health Be Affected?, Joseph T. Barry

Honors Projects

This paper details how ongoing climate change will continue to affect the future of humanity. More specifically, this paper seeks to begin a conversation about how climate change impacts vectors and vector-borne pathogens and how both of these ultimately impact the future of human health. Three different vectors and three different pathogens are compared to provide an overview of how climate change may benefit these vectors and their associated pathogens. The vectors species selected for this comparative study are: (i) mosquitoes (Diptera, family Culicine), (ii) ticks (superorder Parasitiformes, order Ixodida), and (iii) kissing bugs (Hemiptera, subfamily Triatominae). Yellow fever virus …

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An Overview Of The Current Research On Epiphyte Ecology, Kelsey Inman-Carter May 2022

An Overview Of The Current Research On Epiphyte Ecology, Kelsey Inman-Carter

Honors Projects

Epiphytes are non-parasitic, photosynthetic organisms that depend on other photosynthetic host organisms for support. Epiphytes can be found both in aquatic and terrestrial habitats. The interactions between epiphytes and their hosts can vary based on both their habitat and the features of individual hosts. This review explores the many facets of epiphyte research, including: the diversity of epiphytes in aquatic and terrestrial habitats; the effects of host-epiphyte interactions on the hosts; and the abiotic and biotic interactions that together determine epiphyte community composition.

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Effects Of 2,4-Di-Tert-Butylphenol On Osteogenic And Myogenic Differentiation Of Human Induced Pluripotent Stem Cells, Thanh-Bình Dương May 2022

Effects Of 2,4-Di-Tert-Butylphenol On Osteogenic And Myogenic Differentiation Of Human Induced Pluripotent Stem Cells, Thanh-Bình Dương

All Theses

Synthetic phenolic antioxidants (SPAs) are a class of compounds used to increase the durability of polymers as well as to increase the shelf-life of food, cosmetics, and other personal care items. Of these SPAs is 2,4-di-tert-butylphenol (2,4-DBP). 2,4-DBP is primarily used in polyethylene crosspolymer pipes, which are now used as a replacement for the traditional copper pipes for household water distribution. However, 2,4-DBP has been found to leach from these pipes into the water, enabling a mode of exposure to humans. 2,4-DBP has been detected in human urine, serum, but more importantly, maternal serum, placenta, and cord blood. …

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Food Quality, Security, And Thermal Refuge Influence The Use Of Microsites And Patches By Pygmy Rabbits (Brachylagus Idahoensis) Across Landscapes And Seasons, Peter J. Olsoy, Charlotte R. Milling, Jordan D. Nobler, Meghan J. Camp, Lisa A. Shipley, Jennifer S. Forbey, Janet L. Rachlow, Daniel H. Thornton May 2022

Food Quality, Security, And Thermal Refuge Influence The Use Of Microsites And Patches By Pygmy Rabbits (Brachylagus Idahoensis) Across Landscapes And Seasons, Peter J. Olsoy, Charlotte R. Milling, Jordan D. Nobler, Meghan J. Camp, Lisa A. Shipley, Jennifer S. Forbey, Janet L. Rachlow, Daniel H. Thornton

Biology Faculty Publications and Presentations

How intensely animals use habitat features depends on their functional properties (i.e., how the feature influences fitness) and the spatial and temporal scale considered. For herbivores, habitat use is expected to reflect the competing risks of starvation, predation, and thermal stress, but the relative influence of each functional property is expected to vary in space and time. We examined how a dietary and habitat specialist, the pygmy rabbit (Brachylagus idahoensis), used these functional properties of its sagebrush habitat—food quality, security, and thermal refuge—at two hierarchical spatial scales (microsite and patch) across two seasons (winter and summer). At the …

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Seasonal Trends In Adult Apparent Survival And Reproductive Trade-Offs Reveal Potential Constraints To Earlier Nesting In A Migratory Bird, Kathleen R. Callery, John A. Smallwood, Anjolene R. Hunt, Emilie R. Snyder, Julie A. Heath May 2022

Seasonal Trends In Adult Apparent Survival And Reproductive Trade-Offs Reveal Potential Constraints To Earlier Nesting In A Migratory Bird, Kathleen R. Callery, John A. Smallwood, Anjolene R. Hunt, Emilie R. Snyder, Julie A. Heath

Biology Faculty Publications and Presentations

Birds aim to optimize resources for feeding young and self-maintenance by timing reproduction to coincide with peak food availability. When reproduction is mistimed, birds could incur costs that affect their survival. We studied whether nesting phenology correlated with the apparent survival of American kestrels (Falco sparverius) from two distinct populations and examined trends in clutch-initiation dates. We estimated apparent survival using multi-state mark-recapture models with nesting timing, nesting success, sex, age, and weather covariates. Nesting timing predicted the apparent survival of successful adults; however, the effect differed between populations. Early nesting kestrels had higher apparent survival than later …

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Tree Species Diversity Increases With Conspecific Negative Density Dependence Across An Elevation Gradient, Joseph A. Lamanna, F. Andrew Jones, Davod M. Bell, Robert J. Pabst, David C. Shaw May 2022

Tree Species Diversity Increases With Conspecific Negative Density Dependence Across An Elevation Gradient, Joseph A. Lamanna, F. Andrew Jones, Davod M. Bell, Robert J. Pabst, David C. Shaw

Biological Sciences Faculty Research and Publications

Elevational and latitudinal gradients in species diversity may be mediated by biotic interactions that cause density-dependent effects of conspecifics on survival or growth to differ from effects of heterospecifics (i.e. conspecific density dependence), but limited evidence exists to support this. We tested the hypothesis that conspecific density dependence varies with elevation using over 40 years of data on tree survival and growth from 23 old-growth temperate forest stands across a 1,000-m elevation gradient. We found that conspecific-density-dependent effects on survival of small-to-intermediate-sized focal trees were negative in lower elevation, higher diversity forest stands typically characterised by warmer temperatures and greater …

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Fluctuating Parasite Prevalence Is Not Linked To Patterns Of Mhc Class Ii-Ss Diversity In An Island Endemic Reptile, Gina Zwicky May 2022

Fluctuating Parasite Prevalence Is Not Linked To Patterns Of Mhc Class Ii-Ss Diversity In An Island Endemic Reptile, Gina Zwicky

LSU New Orleans Theses and Dissertations

Few studies have explored the evolutionary mechanisms that maintain adaptive immunogenetic diversity in nature. We took advantage of museum samples to test for evidence of parasite-mediated fluctuating selection at MHC Class II-ß loci in an endemic island reptile. The Saban anole Anolis sabanus is commonly infected with three species of malaria (Plasmodium). Proportions of each parasite species detected in anole blood samples fluctuated over space and time, suggesting competitive interactions between parasites or differences in vector ecology. Our analyses of parasite prevalence and MHC Class II-ß allelic variation found that malaria infection was not associated with patterns of …

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Seasonal Trends In Adult Apparent Survival And Reproductive Trade-Offs Reveal Potential Constraints To Earlier Nesting In A Migratory Bird, Kathleen R. Callery, John A. Smallwood, Anjolene R. Hunt, Emilie R. Snyder, Julie A. Heath May 2022

Seasonal Trends In Adult Apparent Survival And Reproductive Trade-Offs Reveal Potential Constraints To Earlier Nesting In A Migratory Bird, Kathleen R. Callery, John A. Smallwood, Anjolene R. Hunt, Emilie R. Snyder, Julie A. Heath

Department of Biology Faculty Scholarship and Creative Works

Birds aim to optimize resources for feeding young and self-maintenance by timing reproduction to coincide with peak food availability. When reproduction is mistimed, birds could incur costs that affect their survival. We studied whether nesting phenology correlated with the apparent survival of American kestrels (Falco sparverius) from two distinct populations and examined trends in clutch-initiation dates. We estimated apparent survival using multi-state mark-recapture models with nesting timing, nesting success, sex, age, and weather covariates. Nesting timing predicted the apparent survival of successful adults; however, the effect differed between populations. Early nesting kestrels had higher apparent survival than later nesters in …

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Functional Role Of Ppal And Potential For Moss In Industrial Applications., Susana Perez Martinez May 2022

Functional Role Of Ppal And Potential For Moss In Industrial Applications., Susana Perez Martinez

Electronic Theses and Dissertations

This dissertation is an examination and characterization of the functional roles of PPAL. PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT-LIKE (PPAL) is a recently discovered gene. PPAL homologs are present in all plants and many animals, where its function is largely unknown. It is possible that PPAL could participate in prenylation processes since it shares similarity to the α subunits of known prenylation enzymes. Prenylation is a post-translational modification of proteins that involves the addition of a lipid moiety to proteins to facilitate membrane targeting and association and promote protein-protein interactions. Prenylation has important roles in plant growth and development, including …

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Naphthalene And Anthracene Degrading Potentials Of Bacteria Isolated From Soil Samples With Evidence Of Polycyclic Aromatic Hydrocarbon(Pah) Contamination, Olatunde Clement Akinola May 2022

Naphthalene And Anthracene Degrading Potentials Of Bacteria Isolated From Soil Samples With Evidence Of Polycyclic Aromatic Hydrocarbon(Pah) Contamination, Olatunde Clement Akinola

Theses (2016-Present)

Polycyclic Aromatic Hydrocarbon (PAH) from crude oil and other sources is one of the most serious environmental problems. PAH has an adverse effect on human health, water bodies and agricultural products. Removal of PAH through the physical and chemical methods are expensive and not environmentally friendly. Bioremediation, which is the use of microorganisms to degrade environmental pollutants like naphthalene and anthracene and render them less toxic, provides a cheaper and safer method. The objective of this research is to study the naphthalene and anthracene degrading potentials of bacteria isolated from soil samples with evidence of cude oil contamination. Another objective …

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Identifying Genetic Differences Among African American And Caucasian Triple Negative Breast Cancer Genotypes, Christopher Jordan Dixon May 2022

Identifying Genetic Differences Among African American And Caucasian Triple Negative Breast Cancer Genotypes, Christopher Jordan Dixon

Theses (2016-Present)

Triple negative breast cancers (TNBC) are closely related to basal-like cancers and classified based on their molecular signatures and their progenitor cell type. TNBCs lack the presence of three common types of receptors known to fuel breast cancer growth: estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptors 2 (HER2neu). TNBC represent 10-20% of all molecular breast cancer subtypes. Even though genomic and transcriptome analyses show that many of the molecular signatures associated with TNBC are not related to ethnicity, clinicians and researchers find that African American (AA) TNBC women have higher mortality rates compared to Caucasian …

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Characterization Of The Cell Cycle Dependent Kinase Inhibitor P27kip1 In The Stem-Like Properties Of Breast Cancer Stem Cells, Jaz-Mine Mccovins May 2022

Characterization Of The Cell Cycle Dependent Kinase Inhibitor P27kip1 In The Stem-Like Properties Of Breast Cancer Stem Cells, Jaz-Mine Mccovins

Theses (2016-Present)

Breast cancer is the second leading cause of cancer death among American women. Traditional therapies, such as chemotherapy and radiation therapy, target proliferative cells within the tumor bulk. However, these treatments do not provide long-term disease survival because they fail to eliminate a small population of long-lived tumor initiating cells known as breast cancer stem cells (CSCs). Two features of CSCs are that they slowly divide and are more resistant to conventional anti-cancer treatments due to altered cellular machinery. It is the breast CSC subpopulation that develops new tumors which have the potential to lead to recurrence. However, the mechanism …

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Experimental Validation Of Gene Expression Of Mybl1, Mybl2, Ubxn8, And Adrm1 Genes In Triple Negative Breast Cancer Cell Lines, Esther Jensinne Nsende May 2022

Experimental Validation Of Gene Expression Of Mybl1, Mybl2, Ubxn8, And Adrm1 Genes In Triple Negative Breast Cancer Cell Lines, Esther Jensinne Nsende

Theses (2016-Present)

A previous study conducted in our laboratory demonstrated V-Myb Avian Myeloblast Viral Oncogene Homolog Like 1 (MYBL1) gene over-expression in triple negative breast cancer (TNBC) compared to normal, some luminal, and a subpopulation of other TNBC. The MYBL1 gene belongs to the Avian myeloblastosis virus (MYB) family and is classified as proto-oncogene that functions as a strong transcription factor. The MYBL1 gene is related to cancer progression which involves dysregulation of cell cycle signaling, apoptosis and differentiation processes. A primary goal of our laboratory is to further characterize MYBL1 gene expression in TNBC samples. To achieve this goal, we performed …

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