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2019

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Articles 1411 - 1440 of 1905

Full-Text Articles in Biology

Cognitive Rigidity In Patients With Anorexia Nervosa, Miriam Sheynblyum Jan 2019

Cognitive Rigidity In Patients With Anorexia Nervosa, Miriam Sheynblyum

The Science Journal of the Lander College of Arts and Sciences

Anorexia Nervosa (AN) is a psychiatric disorder characterized by significantly low body weight and over-evaluation of weight and shape in self-identity. The complex etiology of Anorexia Nervosa renders many current treatments ineffective, thereby prolonging the course of the illness. Among the many psychological and behavioral features of AN, cognitive features like obsessiveness, rigidity, and perfectionism are often described. Patients hold firm beliefs about an ideal body weight and find it difficult to alter their thinking patterns. Recent studies have identified a pathway to understanding this disorder through characterization of it’s cognitive features. With this research, advances have been made in …

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Phylogenetic Origins For Severe Acetaminophen Toxicity In Snake Species Compared To Other Vertebrate Taxa, Peter Van Den Hurk, Harold M.I. Kerkkamp Jan 2019

Phylogenetic Origins For Severe Acetaminophen Toxicity In Snake Species Compared To Other Vertebrate Taxa, Peter Van Den Hurk, Harold M.I. Kerkkamp

Publications

While it has been known for a while that some snake species are extremely sensitive to acetaminophen, the underlying mechanism for this toxicity has not been reported. To investigate if essential detoxification enzymes are missing in snake species that are responsible for biotransformation of acetaminophen in other vertebrate species, livers were collected from a variety of snake species, together with samples from alligator, snapping turtle, cat, rat, and cattle. Subcellular fractions were analyzed for enzymatic activities of phenol-type sulfotransferase and UDP‑glucuronosyltransferase, total glutathione S‑transferase, and N‑acetyltransferase. The results showed that none of the snake species, together …

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Ua66/6/3/3 Ogden College Of Science & Engineering Biology Student Organizations Beta Beta Beta, Wku Archives Jan 2019

Ua66/6/3/3 Ogden College Of Science & Engineering Biology Student Organizations Beta Beta Beta, Wku Archives

WKU Archives Collection Inventories

Records created by and about the Beta Beta Beta Club.

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Laboratory Acclimation To Autumn-Like Conditions Induces Freeze Tolerance In The Spring Field Cricket Gryllus Veletis (Orthoptera: Gryllidae), Jantina Toxopeus, Alexander H. Mckinnon, Tomáš Štětina, Kurtis F. Turnbull, Brent J Sinclair Jan 2019

Laboratory Acclimation To Autumn-Like Conditions Induces Freeze Tolerance In The Spring Field Cricket Gryllus Veletis (Orthoptera: Gryllidae), Jantina Toxopeus, Alexander H. Mckinnon, Tomáš Štětina, Kurtis F. Turnbull, Brent J Sinclair

Biology Publications

Many temperate insects encounter temperatures low enough to freeze their body fluids. Remarkably, some insects are freeze-tolerant, surviving this internal ice formation. However, the mechanisms underlying freeze tolerance are not well-understood, in part due to a lack of tractable model organisms. We describe a novel laboratory model to study insect freeze tolerance, the spring field cricket Gryllus veletis (Orthopera: Gryllidae). Following acclimation to six weeks of decreasing temperature and photoperiod, G. veletis become freeze-tolerant, similar to those exposed to natural autumn conditions in London, Ontario, Canada. Acclimated crickets suppress their metabolic rate by c. 33%, and survive freezing for up …

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Effects Of Rainbow Trout On Brook Trout Population Size In Tributaries To Lake Superior In Cook County, Minnesota, Craig Tangren Jan 2019

Effects Of Rainbow Trout On Brook Trout Population Size In Tributaries To Lake Superior In Cook County, Minnesota, Craig Tangren

Journal of Earth and Life Science

This study looked at the effects of Rainbow Trout stocking on the size of Brook Trout populations above migratory barriers. Linear mixed effects models were used to determine if there was a relationship between Brook Trout and Rainbow Trout catch rates. Age 1 or older Brook Trout populations were influenced by relative abundance of age 1 or older Rainbow Trout, according to the best supported model based on AIC scores. Population responses varied by stream, ranging along a gradient from high catch rates with a positive relationship to a negative relationship with low relative abundances. Streams with a positive relationship …

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Functional Diversity And Restoration Of Meadows In Northeast Ohio, Keri Plevniak Jan 2019

Functional Diversity And Restoration Of Meadows In Northeast Ohio, Keri Plevniak

ETD Archive

Restoration outcomes can be variable and there is a need to understand the short- and long-term responses of the vegetation community. It is important to see if management goals are being met by evaluating restoration outcomes. Restoration goals often include establishing native species, increasing conservation value, and providing pollinator resources throughout the year. Assessing communities is commonly done though a taxonomic approach by using species presence and abundance. Another method of evaluation is through functional traits or species traits and their abundance. Both give different perspectives on how the community is achieving management goals. While taxonomic assessments can give insight …

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Role Of Ribosomal Protein Us9/Ys16 In Translation Initiation And Elongation In Yeast Saccharomyces Cerevisiae., Supriya Jindal Jan 2019

Role Of Ribosomal Protein Us9/Ys16 In Translation Initiation And Elongation In Yeast Saccharomyces Cerevisiae., Supriya Jindal

ETD Archive

The process of translation in all living cells is performed by ribosomes and is divided into four major steps (initiation, elongation, termination and ribosome recycling). Ribosomes consist of ribosomal RNA (rRNA) and proteins and are composed of two subunits small and large. There are three major sites for tRNA binding within ribosome: the (aminoacyl) A-site which accepts the aminoacyl (aa)-tRNA; the P-site, where the peptidyl-tRNA is formed and the (exit) E-site, where deacylated tRNA exits the ribosome. These sites are formed by both rRNA and ribosomal proteins. Though rRNA are involved in the catalysis of protein synthesis, the contribution of …

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Investigation Of Ires-Mediated Translation Of Puma Mrna: Initiation Factor Requirements And Search For Itafs, Amra Ismail Jan 2019

Investigation Of Ires-Mediated Translation Of Puma Mrna: Initiation Factor Requirements And Search For Itafs, Amra Ismail

ETD Archive

Translation initiation is the rate-limiting and tightly regulated step of protein synthesis. Cap-dependent translation initiation accounts for about 95% of cellular mRNAs. Around 3-5% of cellular mRNAs have been found to contain a cis-regulatory element (IRES) which can recruit ribosomes in a cap-independent manner. IRESs support protein synthesis under cellular stress conditions when cap-dependent translation is inhibited. Differentiation in 23A2 myoblast cells can be induced by culturing cells in serum-free differentiating media (DM). During 23A2 cellular myoblast differentiation, approximately 30% of cells undergo apoptosis as a result of stress caused by serum withdrawal in order to induce differentiation. The expression …

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Demonstration Of Single Ion Channel Activity In Lipid Bilayers With Temperature Control, Alex Van Kooten, Brian Seper, Loren Haarsma Jan 2019

Demonstration Of Single Ion Channel Activity In Lipid Bilayers With Temperature Control, Alex Van Kooten, Brian Seper, Loren Haarsma

Summer Research

Lipids are fat-soluble molecules that can naturally form bilayers when exposed to water. Lipid bilayers form the outer boundary of cells, providing a way for cells to isolate themselves from their environment. While bilayer membranes are generally impermeable to ions, proteins known as ion channels allow for ion transport across the membrane. Gramicidin A is one such molecule whose behavior has been studied. While some experimental and computational analysis of gramicidin A has been performed1,2,3, more work is needed to systematically study this ion channel’s behavior at high temperatures (above 50 °C) and in bilayers composed of different lipids. We …

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Towards A Developmental Biology Of Holobionts, Scott F. Gilbert Jan 2019

Towards A Developmental Biology Of Holobionts, Scott F. Gilbert

Biology Faculty Works

We do not develop as monogenomic organisms, instructed solely from the DNA and cytoplasm of the zygote. Rather, we are holobionts, symbiotic consortia containing numerous microbial genomes, whose signals are critically important for our normal development. Microbes play crucial roles in forming and maturing animal guts, immune systems, nervous systems, and reproductive organs. In some species, they regulate such developmental phenomena as the proper orientation of the anterior-posterior axis and metamorphosis. One of the biggest challenges to developmental biology, then, is studying the developmental biology of holobionts, where co-development is the rule, and where the body is seen as a …

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Nineteen Years Of Consistently Positive And Strong Female Mate Preferences Despite Individual Variation, M. J. Ryan, K. A. Akre, Alexander T. Baugh, X. E. Bernal, A. M. Lea, C. Leslie, M. B. Still, D. Wylie, A. S. Rand Jan 2019

Nineteen Years Of Consistently Positive And Strong Female Mate Preferences Despite Individual Variation, M. J. Ryan, K. A. Akre, Alexander T. Baugh, X. E. Bernal, A. M. Lea, C. Leslie, M. B. Still, D. Wylie, A. S. Rand

Biology Faculty Works

Sexual selection driven by mate choice has generated some of the most astounding diversity in nature, suggesting population-level preferences should be strong and consistent over many generations. On the other hand, mating preferences are among the least repeatable components of an individual animal’s phenotype, suggesting low consistency across an animal’s lifetime. Despite decades of intensive study of sexual selection there is almost no information about the strength and consistency of preferences across many years. In this study we present the results of over 5000 mate choice tests with a species of wild frog conducted over 19 consecutive years. Results show …

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What Is The Availability Of Iodised Salt In Supermarkets On The Island Of Ireland?, Mark Shaw, Anne P. Nugent, Breige A. Mcnulty, Janette Walton, Michaela Mchugh, Ashley Kane, Aoibhin Moore Heslin, Eoin James Morrissey, Karen Mullan, Jayne V. Woodside Jan 2019

What Is The Availability Of Iodised Salt In Supermarkets On The Island Of Ireland?, Mark Shaw, Anne P. Nugent, Breige A. Mcnulty, Janette Walton, Michaela Mchugh, Ashley Kane, Aoibhin Moore Heslin, Eoin James Morrissey, Karen Mullan, Jayne V. Woodside

Dept. of Biological Sciences Preprints

Iodine deficiency remains a global nutritional public health challenge, with evidence suggesting borderline adequate or even deficient status for UK and Irish subpopulations such as schoolgirls and pregnant women. The solution, according to the WHO, is salt iodisation, but it is not known how widely available iodised salt is in supermarkets. Iodised salt availability was determined by a shelf survey of 89 supermarket stores on the island of Ireland (n = 30 in Northern Ireland and n = 59 in the Republic of Ireland) from September 2018 to January 2019, to take into account factors such as store type, …

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Frequent Prescribed Fires Can Reduce Risk Of Tick-Borne Diseases, Elizabeth R. Gleim Jan 2019

Frequent Prescribed Fires Can Reduce Risk Of Tick-Borne Diseases, Elizabeth R. Gleim

Environmental Studies / Environmental Science Faculty Scholarship

Recently, a two-year study found that long-term prescribed fire significantly reduced tick abundance at sites with varying burn regimes (burned surrounded by burned areas [BB], burned surrounded by unburned areas [BUB], and unburned surrounded by burned areas [UBB]). In the current study, these ticks were tested for pathogens to more directly investigate the impacts of long-term prescribed burning on human disease risk. A total of 5,103 ticks (4,607 Amblyomma americanum, 76 Amblyomma maculatum, 383 Ixodes scapularis, two Ixodes brunneus, and 35 Dermacentor variabilis) were tested for Borrelia spp., Rickettsia spp., Ehrlichia spp., and Anaplasma phagocytophilum. Long-term prescribed fire did not …

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Crossed Tracks: Mesolimulus, Archaeopteryx, And The Nature Of Fossils, Leonard Finkelman Jan 2019

Crossed Tracks: Mesolimulus, Archaeopteryx, And The Nature Of Fossils, Leonard Finkelman

Faculty Publications

Organisms leave a variety of traces in the fossil record. Among these traces, vertebrate and invertebrate paleontologists conventionally recognize a distinction between the remains of an organism’s phenotype (body fossils) and the remains of an organism’s life activities (trace fossils). The same convention recognizes body fossils as biological structures and trace fossils as geological objects. This convention explains some curious practices in the classification, as with the distinction between taxa for trace fossils and for tracemakers. I consider the distinction between “parallel taxonomies,” or parataxonomies, which privileges some kinds of fossil taxa as “natural” and others as “artificial.” The motivations …

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Betting & Hierarchy In Paleontology, Leonard Finkelman Jan 2019

Betting & Hierarchy In Paleontology, Leonard Finkelman

Faculty Publications

In his Rock, Bone, and Ruin: An Optimist’s Guide to the Historical Sciences, Adrian Currie argues that historical scientists should be optimistic about success in reconstructing the past on the basis of future research. This optimism follows in part from examples of success in paleontology. I argue that paleontologists’ success in these cases is underwritten by the hierarchical nature of biological information: extinct organisms have extant analogues at various levels of taxonomic, ecological, and physiological hierarchies, and paleontologists are adept at exploiting analogies within one informational hierarchy to infer information in another. On this account, fossils serve the role …

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Predicting The Structure And Selectivity Of Coiled-Coil Proteins, Mojtaba Jokar Jan 2019

Predicting The Structure And Selectivity Of Coiled-Coil Proteins, Mojtaba Jokar

Wayne State University Dissertations

A coiled-coil protein structure consists of two (in coiled-coil dimers) or more interacting α-helical strands that together form a left-handed supercoil structure. Many coiled-coil proteins are involved in significant biological functions such as the regulation of gene expression, known as transcription factors. Also coiled-coil structures entail unique mechanical properties critical to the function and integrity of various motor proteins, cytoskeletal filaments and extra-cellular matrix proteins. Engineering these transcription factors is also expected to create more efficient and practical solutions to treat neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion …

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Does In-Vitro Fertilization Increase The Risk For Birth Defects?, Tehila Tropper Jan 2019

Does In-Vitro Fertilization Increase The Risk For Birth Defects?, Tehila Tropper

The Science Journal of the Lander College of Arts and Sciences

Since 1978 when the first “petri dish” baby was born, In-Vitro Fertilization (IVF) has been used as a tool to give couples struggling with infertility the opportunity to have children. Using this method of Assisted Reproductive Technology (ART), the woman is given medication to stimulate her ovaries for the maturation of multiple eggs, which are then retrieved via needle aspiration, fertilized in a petri dish, and inserted in the uterus with the hopes of achieving a successful pregnancy. Many times IVF is completed with another technique known as Intracytoplasmic Sperm Injection (ICSI), where the sperm is injected straight into the …

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Bog Flora In The Grand Rapids, Michigan, Area: A Comparative Study Across Sites And Over Time O 1901 To 2017, Devani Antuma Jolman, Jenna L. Van Donselaar, David P. Warners, Garrett E. Crow Jan 2019

Bog Flora In The Grand Rapids, Michigan, Area: A Comparative Study Across Sites And Over Time O 1901 To 2017, Devani Antuma Jolman, Jenna L. Van Donselaar, David P. Warners, Garrett E. Crow

Faculty and Professional Research

Michigan’s natural landscape includes a diverse assemblage of ecosystems, among the most distinctive of which are peatlands, and more specifically, those known colloquially as “bogs.” When botanist Emma J. Cole published the Grand Rapids Flora in 1901, she included a large number of bog species documented in the greater Grand Rapids area (16 townships in two counties, an area of 585 square miles). Cole’s Flora is still the most comprehensive catalog of vascular plants found in West Michigan. This study is part of an ongoing update of Cole’s work undertaken by the Calvin University Herbarium to relocate and inventory Emma …

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Four Draft Single-Cell Genome Sequences Of Novel, Nearly Identical Kiritimatiellaeota Strains Isolated From The Continental Deep Subsurface, Joshua D. Sackett, Brittany R. Kruger, Eric Becraft, Jessica K. Jarett, Ramunas Stepanauskas, Tanja Woyke, Duane P. Moser Jan 2019

Four Draft Single-Cell Genome Sequences Of Novel, Nearly Identical Kiritimatiellaeota Strains Isolated From The Continental Deep Subsurface, Joshua D. Sackett, Brittany R. Kruger, Eric Becraft, Jessica K. Jarett, Ramunas Stepanauskas, Tanja Woyke, Duane P. Moser

Biology

The recently proposed bacterial phylum Kiritimatiellaeota represents a globally distributed monophyletic clade distinct from other members of the Planctomycetes, Verrucomicrobia, and Chlamydiae (PVC) superphylum. Here, we present four phylogenetically distinct single-cell genome sequences from within the Kiritimatiellaeota lineage sampled from deep continental subsurface aquifer fluids of the Death Valley Regional Flow System in the United States.

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Hydrogen-Based Metabolism As An Ancestral Trait In Lineages Sibling To The Cyanobacteria, Paula B. Matheus Camevali, Frederik Schulz, Cindy J. Castelle, Rose S. Kantor, Patrick M. Shih, Itai Sharon, Joanne M. Santini, Matthew R. Olm, Yuki Amano, Brian C. Thomas, Karthik Anantharaman, David Burstein, Eric D. Becraft, Ramunas Stepanauskas, Tanja Woyke, Jillian F. Banfield Jan 2019

Hydrogen-Based Metabolism As An Ancestral Trait In Lineages Sibling To The Cyanobacteria, Paula B. Matheus Camevali, Frederik Schulz, Cindy J. Castelle, Rose S. Kantor, Patrick M. Shih, Itai Sharon, Joanne M. Santini, Matthew R. Olm, Yuki Amano, Brian C. Thomas, Karthik Anantharaman, David Burstein, Eric D. Becraft, Ramunas Stepanauskas, Tanja Woyke, Jillian F. Banfield

Biology

The evolution of aerobic respiration was likely linked to the origins of oxygenic Cyanobacteria. Close phylogenetic neighbors to Cyanobacteria, such as Margulisbacteria (RBX-1 and ZB3), Saganbacteria (WOR-1), Melainabacteria and Sericytochromatia, may constrain the metabolic platform in which aerobic respiration arose. Here, we analyze genomic sequences and predict that sediment-associated Margulisbacteria have a fermentation-based metabolism featuring a variety of hydrogenases, a streamlined nitrogenase, and electron bifurcating complexes involved in cycling of reducing equivalents. The genomes of ocean-associated Margulisbacteria encode an electron transport chain that may support aerobic growth. Some Saganbacteria genomes encode various hydrogenases, and others may be able to use …

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The Hyperaccumulation Of Zinc In Sunflowers And Its Effect On Disease Resistance, Rayner J. Seavey Jan 2019

The Hyperaccumulation Of Zinc In Sunflowers And Its Effect On Disease Resistance, Rayner J. Seavey

Honors Undergraduate Theses

Sunflowers are considered to be a part of a group of plants known as hyperaccumulators that share the ability to accumulate high amounts of heavy metals in the above ground organs, far in excess of the levels found in other species, often without suffering any phytotoxic effects. Quantifying the effects of zinc accumulation through the lens of the elemental defense hypothesis is essential for uncovering if there is a means to increase herbivore resistance in agricultural settings without the use of external interventions such as pesticides. A greenhouse study was conducted on four widely grown commercial cultivars of sunflower. Each …

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Capillary Electrophoresis Buffer Optimization For Plant Tissue Analysis, Rebekah Davis Jan 2019

Capillary Electrophoresis Buffer Optimization For Plant Tissue Analysis, Rebekah Davis

Honors Undergraduate Theses

Capillary electrophoresis (CE) is an analytical chemistry approach that allows for the efficient separation by charge of diverse classes of compounds for analysis, including secondary metabolites. The goal of this work was to optimize a buffer system for plant tissue analysis using micellar electrokinetic chromatography (MEKC), and by doing so to understand the role of buffer components in the performance of this form of capillary electrophoresis. In this experiment we implemented a factorial design to optimize buffer composition for separating plant tissue and secondary metabolites. The results of this experiment will be used to optimize a universal buffer for MEKC …

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Gateway Scholarships In Biological Sciences: Year 2 Annual Report, Vicki Stieha, Julia Oxford, Amy Ulappa, Brittnee Earl, Jennifer Forbey, Kevin Feris, Jocelyn Cullers Jan 2019

Gateway Scholarships In Biological Sciences: Year 2 Annual Report, Vicki Stieha, Julia Oxford, Amy Ulappa, Brittnee Earl, Jennifer Forbey, Kevin Feris, Jocelyn Cullers

Biology Faculty Publications and Presentations

This report summarizes grant activities, progress toward goals, and broader impacts of the Gateway Scholars Program in the Boise State Department of Biological Sciences during the 2018-19 academic year.

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Examining The Role Of Reproductive Interference In The Decline Of Native Green Treefrogs Following Cuban Treefrog Invasions, Joseph Kennedy Jan 2019

Examining The Role Of Reproductive Interference In The Decline Of Native Green Treefrogs Following Cuban Treefrog Invasions, Joseph Kennedy

Electronic Theses and Dissertations

Reproductive interference occurs when the mating behaviors of one species negatively impact the fitness of another species. It is of increasing interest in invasive species biology because the introduction of alien species often leads to novel sexual interactions with native taxa, which can contribute to their decline. I examined whether reproductive interference plays a role in the decline of native green treefrogs (Hyla cinerea) following invasions of Cuban treefrogs (Osteopilus septentrionalis) in the southeastern United States. The impetus for this study revolves around similarities in spectro-temporal features of Cuban treefrog courtship calls and green treefrog aggressive calls. The significance of …

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Identifying Transcription Co-Regulators Of Gcm/Repo In The Development Of Glia In Drosophila Melanogaster, Glendin Kostantinos Pano Jan 2019

Identifying Transcription Co-Regulators Of Gcm/Repo In The Development Of Glia In Drosophila Melanogaster, Glendin Kostantinos Pano

Electronic Theses and Dissertations

The molecular mechanism mediating the differentiation of neural progenitors to either glia or neurons is guided by the gene glial cells missing (gcm), a master regulator of glial cell differentiation. Knockout of this transcription factor (TF) and its homolog gcm2 in the fruit fly Drosophila Melanogaster results in embryos that develop neurons in place of lateral glia. Conversely, overexpression of gcm in those neural progenitors results in embryos that have substantially fewer neurons and excess glia(Jones, et.al, 1995; Hosoya, et.al, 1995; and Vincent, et.al, 1996). Additionally, gcm has also been shown to be involved in the differentiation of blood …

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Effects Of Commercial Formulations Of Glyphosate On Saccharomyces Cerevisiae, Apoorva Ravi Shankar Jan 2019

Effects Of Commercial Formulations Of Glyphosate On Saccharomyces Cerevisiae, Apoorva Ravi Shankar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Commercial formulations of glyphosate are among the most extensively used herbicides around the world. The active ingredient, glyphosate, targets the aromatic amino acid pathway. This pathway is absent in mammals, resulting in low toxicity. Different formulations contain varying adjuvants and surfactants, whose synergistic effects are yet to be extensively studied at the cellular level. In this study, I tested multiple commercial formulations that showed a variation in growth phenotype among different yeast strains. To gain a better understanding of response and resistance mechanisms at the genome and transcriptome level, I carried out an in-lab evolution study, along with a transcriptome …

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Five-Year Response Of Spontaneous Vegetation To Removal Of Invasive Amur Bush Honeysuckle Along An Urban Creek, Rebecca W. Dolan, Kelly H. Brown Jan 2019

Five-Year Response Of Spontaneous Vegetation To Removal Of Invasive Amur Bush Honeysuckle Along An Urban Creek, Rebecca W. Dolan, Kelly H. Brown

Scholarship and Professional Work - LAS

Non-native invasive species have major impacts on landscapes worldwide, but their effects in urban areas are not well documented. We quantified the response of naturally regenerating vegetation along an urban creek to removal of the invasive shrub Lonicera maackii (Amur Bush Honeysuckle). Over the 5-year study, species richness more than doubled. Most new plants were native, disturbance-adapted, early successional species. Trend analysis of function traits revealed annuals that rely on seed dispersal by wind or externally on animals were significantly overrepresented among new plants in comparison to their proportion in the countywide species pool. Increased species richness did not result …

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Fourteen Polymorphic Microsatellite Markers For The Widespread Labrador Tea (Rhododendron Groenlandicum), Matthew L. Sheik, Kitty L. Labounty, Erika Mitchell, Emily L. Gillespie Jan 2019

Fourteen Polymorphic Microsatellite Markers For The Widespread Labrador Tea (Rhododendron Groenlandicum), Matthew L. Sheik, Kitty L. Labounty, Erika Mitchell, Emily L. Gillespie

Scholarship and Professional Work - LAS

No abstract provided.

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Microsatellite Markers For The Biogeographically Enigmatic Sandmyrtle (Kalmia Buxifolia, Phyllodoceae: Ericaceae), Emily L. Gillespie, Tesa Madsen‐Mcqueen, Torsten Eriksson, Adam Bailey, Zack E. Murrell Jan 2019

Microsatellite Markers For The Biogeographically Enigmatic Sandmyrtle (Kalmia Buxifolia, Phyllodoceae: Ericaceae), Emily L. Gillespie, Tesa Madsen‐Mcqueen, Torsten Eriksson, Adam Bailey, Zack E. Murrell

Scholarship and Professional Work - LAS

No abstract provided.

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A Composite Review Of The Proposed Molecular Mechanisms And Genetic Components Underlying Parkinson’S Disease, Paige Brodrick Jan 2019

A Composite Review Of The Proposed Molecular Mechanisms And Genetic Components Underlying Parkinson’S Disease, Paige Brodrick

Scripps Senior Theses

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons present in the substantia nigra. The clinical presentation of PD includes tremors, slowed movement (bradykinesia), muscle and limb rigidity, and difficulty with walking and balancing. While many environmental factors can affect the onset and progression of the disease, genetic mutations have a large influence. Of the identified PD-linked genetic mutations, mutations in the leucine-rich repeat kinase 2 (LRRK2) are one of the most common genetic causes of PD. Located in endosomes, LRRK2 has been shown to play a role in the sorting and endocytosis …

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