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2016

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Articles 721 - 750 of 1869

Full-Text Articles in Biology

Social Bonds And Recovery: An Analysis Of Hurricane Sandy In The First Year After Landfall, Patricia M. Clay, Lisa L. Colburn, Tarsila Seara May 2016

Social Bonds And Recovery: An Analysis Of Hurricane Sandy In The First Year After Landfall, Patricia M. Clay, Lisa L. Colburn, Tarsila Seara

Biology and Environmental Science Faculty Publications

Hurricane Sandy was one of the most devastating hurricanes to hit US shores. The brunt of the impact was felt in New York and New Jersey, especially among coastal towns such as fishing communities. A survey of these two states assessed social and economic impacts to 958 commercial and recreational fishermen and fishing-related business owners 12 months post-storm. Many businesses and communities were still struggling, due to heavy infrastructure damages and revenue losses with low insurance coverage, but also to disrupted fishing patterns for some species. Social bonds were credited by many as a key aid to recovery. Social bonds …

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Investigation Of The Enviromental Factors Associated With The Temporal Abundance Of Lutzomyia Anthophora On A Ranch Near Poth, Texas, Maha Alshhrany May 2016

Investigation Of The Enviromental Factors Associated With The Temporal Abundance Of Lutzomyia Anthophora On A Ranch Near Poth, Texas, Maha Alshhrany

Theses & Dissertations

Leishmaniasis is caused by infection with protozoan parasites within the genus Leismania transmitted by the bites of female sand flies within the genus Lutzomyia in the New World. This study investigated the seasonal abundance of sand flies and evaluated the correlation of temperature with abundance data. Sand flies were collected at the Garrison ranch near Poth, Texas (28° 57’ 10” N; 98° 7’ 28” W) from May in 2014 through October, 2015. Recorded highest abundance of sand flies in 2014 was in October, 2 females Lu.anthophora and 5 males Lu.anthophora were captured producing 0.58 sand flies /trap night, while, mean …

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Mrub_2874 Is Homologous To B3386 And Mrub_1349 Is Homologous To B2914, But Mrub_1349 Is Not Homologous To B4090, Samantha Murad, Dr. Lori Scott May 2016

Mrub_2874 Is Homologous To B3386 And Mrub_1349 Is Homologous To B2914, But Mrub_1349 Is Not Homologous To B4090, Samantha Murad, Dr. Lori Scott

Meiothermus ruber Genome Analysis Project

ABSTRACT. This project is part of the Meiothermus ruber genome analysis project, which uses the bioinformatics tools associated with the Guiding Education through Novel Investigation – Annotation Collaboration Toolkit (GENI-ACT) to predict gene function. We investigated the biological function of the genes Mrub_2874 and Mrub_1349. We predict that Mrub_2874 encodes the enzyme ribulose-5-phosphate 3-epimerase (DNA coordinates 2912530..2913204 on the reverse strand), which is the first step of the pentose phosphate pathway (KEGG map number 00030). It catalyzes the conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate. The E. coli K12 MG1655 ortholog is predicted to be b3386, which has the gene …

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Role Of Fox01 In Endothelial Cell And Cardiomyocyte Signaling, Taylor Brown May 2016

Role Of Fox01 In Endothelial Cell And Cardiomyocyte Signaling, Taylor Brown

Graduate Theses

The regulation of heart development is an area of research that has important implications for the future treatments of heart injuries. Cardiomyocytes, or cardiac muscle cells, stop proliferating after birth, which limits the adult heart in its ability to repair damaged tissue after injury. The use of targeted therapies to treat heart injury through regenerative mechanisms requires an extremely detailed understanding of the regulatory pathways responsible for directing proliferation of cardiomyocytes during heart development. Interactions between cardiomyocytes in the myocardium with endothelial cells of the endocardium during development are known to occur through cell-cell interactions, including the action of diffusible …

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Innervation Of Gill Lateral Cells In The Bivalve Mollusc Crassostrea Virginica Affects Cellular Membrane Potential And Cilia Activity, Edward J. Catapane, Michael Nelson, Trevon Adams, Margaret A. Carroll May 2016

Innervation Of Gill Lateral Cells In The Bivalve Mollusc Crassostrea Virginica Affects Cellular Membrane Potential And Cilia Activity, Edward J. Catapane, Michael Nelson, Trevon Adams, Margaret A. Carroll

Publications and Research

Gill lateral cells of Crassostrea virginica are innervated by the branchial nerve, which contains serotonergic and dopaminergic fibers that regulate cilia beating rate. Terminal release of serotonin or dopamine results in an increase or decrease, respectively, of cilia beating rate in lateral gill cells. In this study we used the voltage sensitive fluorescent probe DiBAC4(3) to quantify changes in gill lateral cell membrane potential in response to electrical stimulation of the branchial nerve or to applications of serotonin and dopamine, and correlate these changes to cilia beating rates. Application of serotonin to gill lateral cells caused prolonged membrane depolarization, similar …

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Habitat Stratification Of Pithecia Species In The Área De Conservación Regional Comunal Tamshiyacu Tahuayo In The Northeastern Peruvian Amazon, Richard L. Jackson May 2016

Habitat Stratification Of Pithecia Species In The Área De Conservación Regional Comunal Tamshiyacu Tahuayo In The Northeastern Peruvian Amazon, Richard L. Jackson

Graduate Theses

Researchers previously reporting equatorial and monk sakis (Pithecia aequatorialis and P. monachus) occurring sympatrically north of the Amazon River in Peru raised the question of whether the two species were syntopic or separated by habitat. I encountered both species of saki south of the Amazon in Peru in the Área de Conservación Regional Comunal Tamshiyacu Tahuayo (ACRCTT). Initial observations and local lore suggested that in this area equatorial sakis occur predominantly in flooded forests and monk sakis in terra firme. I conducted a six-week survey (324 hours effort, a minimum of 18 groups observed) to test this hypothesis, …

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Assessment Of Behavior And Social Dynamics In A Newly-Forming Group Of Captive Western Lowland Gorillas, Sarah Murphey Huskisson May 2016

Assessment Of Behavior And Social Dynamics In A Newly-Forming Group Of Captive Western Lowland Gorillas, Sarah Murphey Huskisson

Graduate Theses

This study presents behavioral data of a recently-formed western lowland gorilla (Gorilla gorilla gorilla) group at Riverbanks Zoo and Garden in Columbia, South Carolina, from the initial stages of group formation through the first several months after introduction. The group consists of a male (19 years), two half-sisters (both 10 years), and an unrelated female (20 years). I collected 15-minute focal animal samples for three hours twice a week in two observation blocks, the first lasting from 7/17/15 to 9/11/15, and the second lasting from 10/30/15 to 1/3/16. A total of 99.25 observation hours were collected. It was predicted that …

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Perceived Adaptive Capacity And Natural Disasters: A Fisheries Case Study, Tarsila Seara, Patricia M. Clay, Lisa L. Colburn May 2016

Perceived Adaptive Capacity And Natural Disasters: A Fisheries Case Study, Tarsila Seara, Patricia M. Clay, Lisa L. Colburn

Biology and Environmental Science Faculty Publications

Fishermen may be increasingly impacted by natural disasters, given sea level rise and the likely increased frequency and severity of storms associated with climate change. Planning for resiliency in the face of these disasters requires understanding the factors that influence fishermen’s capacity to adapt. The paper examines perceptions of adaptive capacity of New York and New Jersey commercial and for-hire fishermen one year after Hurricane Sandy. Subjective adaptive capacity to changes in the fishery in general and those caused by natural disasters was assessed. A comparison between commercial and for-hire fishermen revealed important differences and similarities with regard to attributes …

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Rac1 And Ire1 Are Required To Prevent Early Loss Of Intestinal Homeostasis In Drosophila Melanogaster, Mauricio M. Ortega May 2016

Rac1 And Ire1 Are Required To Prevent Early Loss Of Intestinal Homeostasis In Drosophila Melanogaster, Mauricio M. Ortega

Dissertations, Masters Theses, Capstones, and Culminating Projects

No abstract available

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Mutation-Driven Divergence And Convergence Indicate Adaptive Evolution Of The Intracellular Human-Restricted Pathogen, Bartonella Bacilliformis, Sandip Paul, Michael F. Minnick, Sujay Chattopadhyay May 2016

Mutation-Driven Divergence And Convergence Indicate Adaptive Evolution Of The Intracellular Human-Restricted Pathogen, Bartonella Bacilliformis, Sandip Paul, Michael F. Minnick, Sujay Chattopadhyay

Biological Sciences Faculty Publications

Among all species of Bartonella, human-restricted Bartonella bacilliformis is the most virulent but harbors one of the most reduced genomes. Carrión's disease, the infection caused by B. bacilliformis, has been afflicting poor rural populations for centuries in the high-altitude valleys of the South American Andes, where the pathogen's distribution is probably restricted by its sand fly vector's range. Importantly, Carrión's disease satisfies the criteria set by the World Health Organization for a disease amenable to elimination. However, to date, there are no genome-level studies to identify potential footprints of B. bacilliformis (patho)adaptation. Our comparative genomic approach demonstrates that the evolution …

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Paradoxical Acclimation Responses In The Thermal Performance Of Insect Immunity., Laura V Ferguson, David E Heinrichs, Brent J Sinclair May 2016

Paradoxical Acclimation Responses In The Thermal Performance Of Insect Immunity., Laura V Ferguson, David E Heinrichs, Brent J Sinclair

Biology Publications

Winter is accompanied by multiple stressors, and the interactions between cold and pathogen stress potentially determine the overwintering success of insects. Thus, it is necessary to explore the thermal performance of the insect immune system. We cold-acclimated spring field crickets, Gryllus veletis, to 6 °C for 7 days and measured the thermal performance of potential (lysozyme and phenoloxidase activity) and realised (bacterial clearance and melanisation) immune responses. Cold acclimation decreased the critical thermal minimum from -0.5 ± 0.25 to -2.1 ± 0.18 °C, and chill coma recovery time after 72 h at -2 °C from 16.8 ± 4.9 to 5.2 …

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Species-Recognition Program: A Computer-Assisted Approach To Recognizing Species, Steve Kelsch, Jeffrey Carmichael May 2016

Species-Recognition Program: A Computer-Assisted Approach To Recognizing Species, Steve Kelsch, Jeffrey Carmichael

Biology Faculty Publications

Species recognition is a crucial component for many types of biological studies. To that end, broadly trained students must be able to accurately identify many different types of organisms. Courses that focus on learning the names of different species traditionally rely on preserved specimens viewed during class or laboratory time. Unfortunately, reliance on preserved specimens comes with many challenges in providing students with an optimal learning experience. The curriculum activity described here uses a modified PowerPoint file (species-recognition program—SRP) as a means of helping students learn to recognize and identify fishes based on subtle visual cues. Our results indicate that …

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A Comparative Study Of Isolation In Headwater Fishes, Bjorn Victor Schmidt May 2016

A Comparative Study Of Isolation In Headwater Fishes, Bjorn Victor Schmidt

Dissertations

Headwater resident fishes may be prone to a high rate of population fragmentation within river networks because large streams have habitat conditions outside of their preferred ecological niche and may limit gene flow in the dendritic ecological network. To investigate patterns of population structure, asymmetrical gene flow, and influences on genetic distance and isolation from connecting habitat pathways, species specific ecological traits, and basin scale characteristics, a multi-species, multi-regional study was performed. Six headwater species of fish from four taxonomic groupings were sampled for genetic material in three regions of paired neighbor drainages and then genotyped for eight microsatellite loci. …

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Defining The Pathway For Misfolded Protein Degradation In Retinitis Pigmentosa Caused By The Rhodopsin-P23h Mutation, Eric Merrell May 2016

Defining The Pathway For Misfolded Protein Degradation In Retinitis Pigmentosa Caused By The Rhodopsin-P23h Mutation, Eric Merrell

Renée Crown University Honors Thesis Projects - All

Retinitis pigmentosa (RP) is a term used to describe a wide variety of inherited degenerative diseases that affect the eye. While there are many causes of this disease, the most commonly found mutation that causes RP in North America is an autosomal dominant missense mutation in rhodopsin (RhoP23H). Previous studies have shown that RhoP23H is predominantly misfolded, resulting in a dramatic loss of the ability to stably bind 11-cis retinal and thus function as a photopigment. Previous work has shown that this process is conserved to some degree across many models, from pigs to mice, and even …

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Optimizing Pharmacological Lifespan Extension: Testing Chemical Compounds For Additive Effects On Longevity, Elizabeth Chao May 2016

Optimizing Pharmacological Lifespan Extension: Testing Chemical Compounds For Additive Effects On Longevity, Elizabeth Chao

Dissertations, Masters Theses, Capstones, and Culminating Projects

No abstract available

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Relationships Between Nutrients, Periphyton Abundance, And Benthic Macroinvertebrate Scrapers In Ozark Highland Streams, Harrison Smith May 2016

Relationships Between Nutrients, Periphyton Abundance, And Benthic Macroinvertebrate Scrapers In Ozark Highland Streams, Harrison Smith

Biological Sciences Undergraduate Honors Theses

We collected samples from seven Arkansas streams during the months of August 2014 and February 2015 with the objective of determining possible relationships between nutrients, periphyton abundance and benthic macroinvertebrates. We hypothesized that periphyton would be positively associated with nutrients, and that increases in periphyton biomass would increase the abundance and diversity of benthic scraper families. Samples were collected from three transects at each site. The periphyton was analyzed for carbon, nitrogen, phosphorus, and ash free dry mass and Chl-a content. Macroinvertebrates families belonging to the feeding group of grazers/scrapers were compared with water column and periphyton nutrient concentrations, as …

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Three-Dimensional Simulation For Fast Forward Flight Of A Calliope Hummingbird, Jialei Song, Bret W. Tobalske, Don Powers, Tyson Hedrick, Haoxiang Luo May 2016

Three-Dimensional Simulation For Fast Forward Flight Of A Calliope Hummingbird, Jialei Song, Bret W. Tobalske, Don Powers, Tyson Hedrick, Haoxiang Luo

Faculty Publications - Department of Biological & Molecular Science

We present a computational study of flapping-wing aerodynamics of a calliope hummingbird (Selasphorus calliope) during fast forward flight. Three-dimensional wing kinematics were incorporated into the model by extracting time-dependent wing position from high-speed videos of the bird flying in a wind tunnel at 8.3 m s−1. The advance ratio, i.e. the ratio between flight speed and average wingtip speed, is around one. An immersed-boundary method was used to simulate flow around the wings and bird body. The result shows that both downstroke and upstroke in a wingbeat cycle produce significant thrust for the bird to overcome …

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Rheb1 Expression In Embryonic And Postnatal Mouse, Qi Tian, James L. Smart, Joachim H. Clement, Yingming Wang, Alex Derkatch, Harald Schubert, Michael V. Danilchik, Daniel L. Marks, Lev M. Federov May 2016

Rheb1 Expression In Embryonic And Postnatal Mouse, Qi Tian, James L. Smart, Joachim H. Clement, Yingming Wang, Alex Derkatch, Harald Schubert, Michael V. Danilchik, Daniel L. Marks, Lev M. Federov

Faculty Publications - Department of Biological & Molecular Science

Ras homolog enriched in brain (RHEB1) is a member within the superfamily of GTP-binding proteins encoded by the RAS oncogenes. RHEB1 is located at the crossroad of several important pathways including the insulin-signaling pathways and thus plays an important role in different physiological processes. To understand better the physiological relevance of RHEB1 protein, the expres-sion pattern of RHEB1 was analyzed in both embryonic (at E3.5–E16.5) and adult (1-month old) mice. RHEB1 immu-nostaining and X-gal staining were used for wild-type and Rheb1 gene trap mutant mice, respectively. These inde-pendent methods revealed similar RHEB1 expression pat-terns during both embryonic and postnatal developments. …

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Scale-Dependent Contributions Of Abiotic And Biotic Factors To Tree Species Composition Patterns In The Us Rocky Mountains, Paige E. Copenhaver-Parry May 2016

Scale-Dependent Contributions Of Abiotic And Biotic Factors To Tree Species Composition Patterns In The Us Rocky Mountains, Paige E. Copenhaver-Parry

Faculty Publications - Department of Biological & Molecular Science

Scale-dependence is recognized as a ubiquitous feature of ecological systems. Ecologists have traditionally hypothesized a hierarchy of factors affecting the composition of ecological communities, with biotic interactions exerting a dominant influence at fine spatial scales, and abiotic factors such as climate driving patterns at broad spatial scales. However, the role of biotic interactions at macroecological scales has been increasingly questioned, with many ecologists hypothesizing that biotic interactions may have discernable effects on species distributions. Here, I evaluate the relative effects of climate and species interactions on composition patterns of tree species in the US Rocky Mountains. At fine spatial scales, …

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Stable Isotopes And The Ecology And Physiology Of Reptiles, Andrew M. Durso May 2016

Stable Isotopes And The Ecology And Physiology Of Reptiles, Andrew M. Durso

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

When animals don’t have enough food, they have to “choose” between “spending” their limited energy on themselves or on their offspring. Biologists think that reptiles can make this choice quickly in response to different environments. But, it can be hard to study these choices because it is hard to convert between, for example, the number of eggs laid and the speed of healing a wound. By using stable isotope chemistry, we can collect more detailed and comparable information about how lizards and other animals spend their limited resources than with any other method. For example, lizards in the wild have …

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Hybridization, Population Genetic Structure And Gene Expression In The Genus Boechera, Martin Peter Schilling May 2016

Hybridization, Population Genetic Structure And Gene Expression In The Genus Boechera, Martin Peter Schilling

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

When we look at life on earth, we can see a lot of different life forms, but we still do not fully understand how these different life forms came to be and at which points in time these life forms began to be different enough from each other so we could call them by different names, or species. Some groups of species on earth, especially plants, seem to reproduce with each other, even though they are already very different from each other so that we call them different species. This process is called hybridization, and it can stir up the …

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Greater Sage-Grouse Vital Rate And Habitat Use Response To Landscape Scale Habitat Manipulations And Vegetation Micro-Sites In Northwestern Utah, Charles P. Sandford May 2016

Greater Sage-Grouse Vital Rate And Habitat Use Response To Landscape Scale Habitat Manipulations And Vegetation Micro-Sites In Northwestern Utah, Charles P. Sandford

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The greater sage-grouse (Centrocercus urophasianus; sage-grouse) has been a species of conservation concern since the early 20th century. The decline of populations has largely been attributed to loss and degradation of sagebrush (Artemisia spp.) habitats. To contribute to the knowledge of sage-grouse ecology and quantify the effectiveness of landscape scale habitat manipulations intended to benefit sage-grouse, I monitored habitat use and vital-rates (i.e., nest and brood success) of 45 sage-grouse females in the Box Ender Sage-Grouse Management Area (SGMA) in northwestern Utah. Using telemetry locations of sage-grouse females with known nest and brood fates, I generated …

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Nocturnal Foraging Enhanced By Enlarged Secondary Eyes In A Net-Casting Spider, Jay A. Stafstrom, Eileen A. Hebets May 2016

Nocturnal Foraging Enhanced By Enlarged Secondary Eyes In A Net-Casting Spider, Jay A. Stafstrom, Eileen A. Hebets

Eileen Hebets Publications

Animals that possess extreme sensory structures are predicted to have a related extreme behavioral function. This study focuses on one such extreme sensory structure—the posterior median eyes of the net-casting spider Deinopis spinosa. Although past research has implicated the importance of vision in the nocturnal foraging habits of Deinopis, no direct link between vision in the enlarged eyes and nocturnal foraging has yet been made. To directly test the hypothesis that the enlarged posterior median eyes facilitate visually based nocturnal prey capture, we conducted repeated-measures, visual occlusion trials in both natural and laboratory settings. Our results indicate that D. …

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Assessment Of American White Pelican Predation And Reproductive Success Of Walleye In The Tamarac River, Mn, Jake Graham May 2016

Assessment Of American White Pelican Predation And Reproductive Success Of Walleye In The Tamarac River, Mn, Jake Graham

Biology Graduate Theses

The Tamarac River is a major tributary of the Red Lakes MN, which provides an economically important multispecies fishery. The river experiences spring spawning migrations of northern pike, walleye, and white suckers. However, limited data exists related to reproductive success of fishes in the river. Furthermore, in the previous decade large congregations of American white pelicans (AWPE) have been observed using the Tamarac River as a foraging ground each spring. Assessing reproductive success of fishes in the Tamarac River provides a more holistic understanding of fish ecology in the river and the importance of the Tamarac River to the Red …

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Characterization Of A Silac Method For Proteomic Analysis Of Primary Rat Microglia, Ping Zhang, Ashley E. Culver-Cochran, Stanley M. Stevens Jr., Bin Liu May 2016

Characterization Of A Silac Method For Proteomic Analysis Of Primary Rat Microglia, Ping Zhang, Ashley E. Culver-Cochran, Stanley M. Stevens Jr., Bin Liu

Molecular Biosciences Faculty Publications

Microglia play important and dynamic roles in mediating a variety of physiological and pathological processes during the development, normal function and degeneration of the central nervous system. Application of SILAC-based proteomic analysis would greatly facilitate the identification of cellular pathways regulating the multifaceted phenotypes of microglia. We and others have successfully SILAC-labeled immortalized murine microglial cell lines in previous studies. In this study, we report the development and evaluation of a SILAC-labeled primary rat microglia model. Although the isotope labeling scheme for primary microglia is drastically different from that of immortalized cell lines, our de novo and uninterrupted primary culture …

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Rna Seq Analysis Of Non-Alcoholic Fatty Liver Disease (Nafld) Induced By Metabolic Syndrome In A Mouse Model, Diego Almanza May 2016

Rna Seq Analysis Of Non-Alcoholic Fatty Liver Disease (Nafld) Induced By Metabolic Syndrome In A Mouse Model, Diego Almanza

Honors College Theses

Metabolic syndrome is often defined by the presence of several factors, including accumulation of abdominal fat, high blood pressure and high blood glucose levels, that increases the risk of developing heart disease, diabetes and cancer. The development of metabolic syndrome has been shown to be very closely linked to lack of physical activity and is increasing concurrent with the rise of obesity rates among adults. Development of metabolic syndrome can have detrimental physiological effects throughout the body and can lead to the development of Non-Alcoholic Fatty Liver Disease (NAFLD). Proper liver function is crucial for the health of the body …

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Stream Benthic Algal Relationships With Multi-Metric Indices Of Sensitivity, Exposure, And Vulnerability To Watershed Land Use Change, With An Emphasis On Unconventional Natural Gas Development, Hannah J. Verkamp May 2016

Stream Benthic Algal Relationships With Multi-Metric Indices Of Sensitivity, Exposure, And Vulnerability To Watershed Land Use Change, With An Emphasis On Unconventional Natural Gas Development, Hannah J. Verkamp

Biological Sciences Undergraduate Honors Theses

Unconventional natural gas (UNG) is harvested using a unique fossil fuel extraction method that uses horizontal drilling and hydraulic fracturing techniques. The combined methods have expanded the industry both nationally and globally, and development has the ability to transform landscapes and impact freshwater resources. Natural gas wells are often near streams, yet substantial knowledge gaps remain as to how and the extent to which development affects surface waters. Stream algal biomass can respond positively to anthropogenic stressors associated with different types of land use, including agriculture. Benthic algal biomass can also positively correlate with UNG well density and proximity to …

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The Mayfly Newsletter, Peter M. Grant May 2016

The Mayfly Newsletter, Peter M. Grant

The Mayfly Newsletter

The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.

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Evaluating The Performance Of In Silico Predictive Models On Detecting Splice-Altering Variants, Erica Cayton May 2016

Evaluating The Performance Of In Silico Predictive Models On Detecting Splice-Altering Variants, Erica Cayton

Dissertations, Masters Theses, Capstones, and Culminating Projects

As with any complex biological pathway, the splicing process has both advantages and obstacles with respect to the diversity and fidelity of protein production. The potential benefits of being able to produce multiple versions of a gene (isoforms) must be weighed against the additional complexity introduced by the noisy and mechanistically complicated process of splicing. Indeed, research has found that errors in splicing can be implicated in an increasing number of disorders. Variants that cause disease may operate by disrupting splicing; however many of the variants are frequently annotated as disrupting function through a missense mutation, or via an unknown …

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Novel Interactome Of Saccharomyces Cerevisiae Myosin Type Ii Identified By A Modified Integrated Membrane Yeast Two-Hybrid (Imyth) Screen, Ednalise Santiago, Pearl Akamine, Jamie Snider, Victoria Wong, Matthew Jessulat, Viktor Deineko, Alla Gagarinova, Hiroyuki Aoki, Zoran Minic, Sadhna Phanse, Andrea San Antonio, Luis A Cubano, Brian C. Rymond, Mohan Babu, Igor Stagljar, Jose R. Rodriguez-Medina May 2016

Novel Interactome Of Saccharomyces Cerevisiae Myosin Type Ii Identified By A Modified Integrated Membrane Yeast Two-Hybrid (Imyth) Screen, Ednalise Santiago, Pearl Akamine, Jamie Snider, Victoria Wong, Matthew Jessulat, Viktor Deineko, Alla Gagarinova, Hiroyuki Aoki, Zoran Minic, Sadhna Phanse, Andrea San Antonio, Luis A Cubano, Brian C. Rymond, Mohan Babu, Igor Stagljar, Jose R. Rodriguez-Medina

Biology Faculty Publications

Nonmuscle myosin type II (Myo1p) is required for cytokinesis in the budding yeast Saccharomyces cerevisiae. Loss of Myo1p activity has been associated with growth abnormalities and enhanced sensitivity to osmotic stress, making it an appealing antifungal therapeutic target. The Myo1p tail-only domain was previously reported to have functional activity equivalent to the full-length Myo1p whereas the head-only domain did not. Since Myo1p tail-only constructs are biologically active, the tail domain must have additional functions beyond its previously described role in myosin dimerization or trimerization. The identification of new Myo1p-interacting proteins may shed light on the other …

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