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2013

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Articles 1021 - 1050 of 1508

Full-Text Articles in Biology

Evolution Of Melanocortin-2 Receptor Activations: Studies On A Mammal And A Fish, Liang Liang Jan 2013

Evolution Of Melanocortin-2 Receptor Activations: Studies On A Mammal And A Fish, Liang Liang

Electronic Theses and Dissertations

The structure and function relationship between melanocortin-2 receptor (MC2R) and ACTH are the most complicated in melanocortin receptor gene family. A comparative study on the activation of human and rainbow trout MC2R will provide a useful model system for understanding how ACTH emerged as the sole ligand for the MC2R of bony vertebrates. This dissertation will discuss how studies utilizing analogs of hACTH(1-24) have revealed two critical amino acid motifs in this ligand (HFRW and KKRRP) which are required for the activation of MC2R. In addition, the KKRRP motif functioned as the unique binding site for MC2R that directly contributes …

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Mitochondrial Glutathione Transport: Implications For Bcl-2 And Neuronal Survival, Heather Marie Wilkins Jan 2013

Mitochondrial Glutathione Transport: Implications For Bcl-2 And Neuronal Survival, Heather Marie Wilkins

Electronic Theses and Dissertations

Oxidative stress is a contributing factor to many neurodegenerative diseases. In particular, mitochondria are a key source of oxidative stress due to electron leakage at the level of the electron transport chain. To combat the endogenous production of reactive oxygen and reactive nitrogen species mitochondria are equipped with several redox-cycling systems, such as glutathione (GSH). Mitochondrial GSH has been shown to be a critical reservoir of this antioxidant, where selective depletion of mitochondrial GSH can induce apoptosis in several systems. Many studies have intricately linked Bcl-2 to cellular GSH status and it has been previously shown that Bcl-2 is a …

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Application Of Remote Sensing In Aquatic Ecosystems, Foad Yousef Jan 2013

Application Of Remote Sensing In Aquatic Ecosystems, Foad Yousef

Dissertations, Master's Theses and Master's Reports - Open

I utilized state the art remote sensing and GIS (Geographical Information System) techniques to study large scale biological, physical and ecological processes of coastal, nearshore, and offshore waters of Lake Michigan and Lake Superior. These processes ranged from chlorophyll a and primary production time series analysies in Lake Michigan to coastal stamp sand threats on Buffalo Reef in Lake Superior. I used SeaWiFS (Sea-viewing Wide Field-of-view Sensor) satellite imagery to trace various biological, chemical and optical water properties of Lake Michigan during the past decade and to investigate the collapse of early spring primary production. Using spatial analysis techniques, I …

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Population Distribution And Abundance Of The Blackfin Sucker (Thoburnia Atripinnis) In The Upper Barren River System, Kentucky And Tennessee., Cory Daniel Stringfield Jan 2013

Population Distribution And Abundance Of The Blackfin Sucker (Thoburnia Atripinnis) In The Upper Barren River System, Kentucky And Tennessee., Cory Daniel Stringfield

Online Theses and Dissertations

The blackfin sucker (Thoburnia atripinnis) is a relatively small species of fish (~155mm) endemic to the headwaters of the Barren River System (UBR) in Kentucky and Tennessee. Due to its isolated distribution and relatively small geographic inhabitance, the blackfin sucker is considered a Species of Greatest Conservation Need (SGCN) in Kentucky by the Kentucky Department of Fish and Wildlife Resources. In addition, it is included in Tennessee's list of rare wildlife as a Species of Special Concern. This study focused on determining the distribution and abundance of the blackfin sucker in those tributaries that comprise the UBR system, as well …

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Ovarian Cycle Activity Varies With Respect To Age And Social Status In Free-Ranging Elephants In Addo Elephant National Park, South Africa, Elizabeth Freeman, Jordana Meyer, Sarah Putman, Bruce A. Schulte, Janine Brown Jan 2013

Ovarian Cycle Activity Varies With Respect To Age And Social Status In Free-Ranging Elephants In Addo Elephant National Park, South Africa, Elizabeth Freeman, Jordana Meyer, Sarah Putman, Bruce A. Schulte, Janine Brown

Biology Faculty Publications

Free-ranging African elephants live in a fission–fusion society, at the centre of which is the matriarch. Matriarchs are generally older females that guide their families to resources and co-ordinate group defense. While much is known about elephant society, knowledge is generally lacking about how age affects the physiology of wild elephants. Investigation of the ovarian activity of free-ranging elephants could provide insight into the reproductive ageing process, with implications for population management. Faecal samples were collected from 46 individuals ranging in age from 14 to 60 years for a 2-year period, and progestagen metabolite analyses were used to examine relationships …

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Descendant Root Volume Varies As A Function Of Root Type: Estimation Of Root Biomass Lost During Uprooting In Pinus Pinaster, Joshua Caplan Jan 2013

Descendant Root Volume Varies As A Function Of Root Type: Estimation Of Root Biomass Lost During Uprooting In Pinus Pinaster, Joshua Caplan

Biology Faculty Research and Scholarship

Root systems of woody plants generally display a strong relationship between the cross- sectional area or cross-sectional diameter (CSD) of a root and the dry weight of biomass (DWd) or root volume (Vd) that has grown (i.e., is descendent) from a point. Specification of this relationship allows one to quantify root architectural patterns and estimate the amount of material lost when root systems are extracted from the soil. However, specifications of this relationship generally do not account for the fact that root systems are comprised of multiple types of roots. We assessed whether the relationship between CSD and Vd varies …

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Matrix Microarchitecture And Myosin Ii Determine Adhesion In 3d Matrices, Kristopher Kubow Jan 2013

Matrix Microarchitecture And Myosin Ii Determine Adhesion In 3d Matrices, Kristopher Kubow

Selected Works

No abstract provided.

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Panama Trip Will Explore Biodiversity Hotspot, Aldemaro Romero Jr. Jan 2013

Panama Trip Will Explore Biodiversity Hotspot, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

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Ua12/13 Big Red, Small Planet, Christian Ryan-Downing , Editor, Leslie North , Editor Jan 2013

Ua12/13 Big Red, Small Planet, Christian Ryan-Downing , Editor, Leslie North , Editor

Sustainability Publications and Resources

At WKU, “The Spirit Makes the Master”. Our commitment to continuous improvement is clearly reflected in our sustainability efforts. WKU’s commitment to sustainability, whether demonstrated in campus operations or in educational programs, helps to ensure that our graduates are prepared to address the complicated environmental, social and economic issues we face today. They will be able to think critically, solve problems creatively and be engaged citizens. If that’s all we accomplish then we will have achieved great success. But our sustainability commitment pays dividends, as it also leads us to reduce our environmental footprint, practice social responsibility, and conserve natural …

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Genomics Of A Metamorphic Timing Qtl: Met1 Maps To A Unique Genomic Position And Regulates Morph And Species-Specific Patterns Of Brain Transcription, Robert B. Page, Meredith A. Boley, D. Kevin Kump, S. Randal Voss Jan 2013

Genomics Of A Metamorphic Timing Qtl: Met1 Maps To A Unique Genomic Position And Regulates Morph And Species-Specific Patterns Of Brain Transcription, Robert B. Page, Meredith A. Boley, D. Kevin Kump, S. Randal Voss

Biology Faculty Publications

Very little is known about genetic factors that regulate life history transitions during ontogeny. Closely related tiger salamanders (Ambystoma species complex) show extreme variation in metamorphic timing, with some species foregoing metamorphosis altogether, an adaptive trait called paedomorphosis. Previous studies identified a major effect QTL (met1) for metamorphic timing and expression of paedomorphosis in hybrid crosses between the biphasic Eastern tiger salamander (Ambystoma tigrinum tigrinum) and the paedomorphic Mexican axolotl (Ambystoma mexicanum). We used existing hybrid mapping panels and a newly created hybrid cross to map the met1 genomic region and determine the …

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A Role For Dynamin-Dependent Endocytosis During Drosophila Gastrulation, Marissa Kay Kuhl Jan 2013

A Role For Dynamin-Dependent Endocytosis During Drosophila Gastrulation, Marissa Kay Kuhl

Electronic Theses and Dissertations

Gastrulation, a process conserved among many higher organisms, is the directed migration of cells into layers that will establish various tissues targeted to become anatomical structures. This process is accomplished through another conserved morphogenetic event, known as cell intercalation. Early in development, this movement of cells within an organized tissue leads to unique cellular arrangements where neighboring cells contract their shared interfaces in order to meet at a shared vertex. In this thesis, I present work that demonstrates a requirement for Dynamin-dependent endocytosis during these contraction events. Using quantitative analysis, I have identified varied cell behaviors during experiments which knockdown …

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Effects Of Storage Conditions On The Morphology And Titer Of Lentiviral Vectors, H. Rahman, Josephine Taylor, Beatrice Clack, R. S. Stewart, Sarah C. Canterberry Jan 2013

Effects Of Storage Conditions On The Morphology And Titer Of Lentiviral Vectors, H. Rahman, Josephine Taylor, Beatrice Clack, R. S. Stewart, Sarah C. Canterberry

Faculty Publications

Lentiviral vectors are commonly used in laboratory experiments to stably integrate transgenes into host genomes. It has long been observed that storage of virus stocks leads to a decrease in viral titer, but the mechanisms driving this decrease have yet to be identified. To that end, lentiviral vector stocks were generated and stored as follows: room temperature for less than one hour, -80ºC for 24 hours, 4ºC for three days and 4ºC for 7 days. These stocks were subsequently evaluated with regard to their transducing ability and their morphology, specifically particle diameter. The vector that was stored at room temperature …

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Differential Habitat Use By Common Watersnakes (Nerodia Sipedon), Lorin A. Neuman-Lee, Andrew M. Durso, Nicholas M. Kiriazis, Melanie J. Olds, Stephen J. Mullin Jan 2013

Differential Habitat Use By Common Watersnakes (Nerodia Sipedon), Lorin A. Neuman-Lee, Andrew M. Durso, Nicholas M. Kiriazis, Melanie J. Olds, Stephen J. Mullin

Faculty Publications

Understanding intraspecific variation in habitat use is important for the management of any species. In many studies of reptiles, habitat use by juveniles is poorly understood when compared to their adult conspecifics because of capture biases and logistical constraints. We compared habitat use between sexes and age classes of Common Watersnakes (Nerodia sipedon) at a reservoir in central Illinois. Juvenile N. sipedon occurred more frequently in habitat with high canopy cover, whereas adult N. sipedon, especially reproductive females, were found exclusively in habitat with no canopy cover. Adult males used both locations equally. We emphasize the need to investigate ontogenetic …

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Differential Jumping Performance In Newly Metamorphosed Blanchard's Cricket Frogs, Acris Blanchardi (Anura: Hylidae), From Fish- And Invertebrate-Dominated Ponds, Taylor L. Hall, Daniel Saenz, Matthew Kwiatkowski Jan 2013

Differential Jumping Performance In Newly Metamorphosed Blanchard's Cricket Frogs, Acris Blanchardi (Anura: Hylidae), From Fish- And Invertebrate-Dominated Ponds, Taylor L. Hall, Daniel Saenz, Matthew Kwiatkowski

Faculty Publications

Organisms that adopt phenotypically plastic anti-predator strategies during larval stages may incur fitness costs later in development. These costs are typically difficult to define in many species. The difficulty of identifying ecological trade-offs may result from experimental comparisons that do not adequately mirror naturally occurring predator-prey relatioships. To examine this, we captured 61 newly metamorphosed Acris blanchardi from ponds dominated either by fish or invertebrate predators. These predators are known to induce alternate phenotypic anti-predator responses at the larval stage. We use jumping performance as a measure of post-metamorphic fitness, and compared the morphological traits and jumping ability of frogs …

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Synergistic Effects Of The Invasive Chinese Tallow (Triadica Sebifera) And Climate Change On Aquatic Amphibian Survival, Daniel Saenz, Erin M. Fucik, Matthew Kwiatkowski Jan 2013

Synergistic Effects Of The Invasive Chinese Tallow (Triadica Sebifera) And Climate Change On Aquatic Amphibian Survival, Daniel Saenz, Erin M. Fucik, Matthew Kwiatkowski

Faculty Publications

Changes in climate and the introduction of invasive species are two major stressors to amphibians, although little is known about the interaction between these two factors with regard to impacts on amphibians. We focused our study on an invasive tree species, the Chinese tallow (Triadica sebifera), that annually sheds its leaves and produces leaf litter that is known to negatively impact aquatic amphibian survival. The purpose of our research was to determine whether the timing of leaf fall from Chinese tallow and the timing of amphibian breeding (determined by weather) influence survival of amphibian larvae. We simulated a …

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Assessment Of Genetic Diversity In Peruvian Amaranth (Amaranthus Caudatus And A. Hybridus) Germplasm Using Single Nucleotide Polymorphism Markers [Abstract], Felix Jimenez, Peter J. Maughan, Aquilino Alvarez, Kiel D. Kielinski, Scott M. Smith, Donald B. Pratt, David B. Elzinga, Eric N. Jellen Jan 2013

Assessment Of Genetic Diversity In Peruvian Amaranth (Amaranthus Caudatus And A. Hybridus) Germplasm Using Single Nucleotide Polymorphism Markers [Abstract], Felix Jimenez, Peter J. Maughan, Aquilino Alvarez, Kiel D. Kielinski, Scott M. Smith, Donald B. Pratt, David B. Elzinga, Eric N. Jellen

Faculty Publications

No abstract provided.

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Parallel Evolution In The Northern Scorpion Paruroctus Boreus, Zachary J. Valois Jan 2013

Parallel Evolution In The Northern Scorpion Paruroctus Boreus, Zachary J. Valois

Biology Posters

No abstract provided.

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Female Mate Choice In Guppies Based On Color Contrast And Sensory Exploitation, Jessica Harmison, Mariah Ogborn, Jory Pett, Desa Tolman Jan 2013

Female Mate Choice In Guppies Based On Color Contrast And Sensory Exploitation, Jessica Harmison, Mariah Ogborn, Jory Pett, Desa Tolman

Biology Posters

No abstract provided.

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Using Operant Conditioning To Train Cervus Canadensis, Jonathan Larson Jan 2013

Using Operant Conditioning To Train Cervus Canadensis, Jonathan Larson

Biology Posters

No abstract provided.

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Sources Of Uncertainty In Nutrient Sampling Below A Point Source, Hayden Campbell Jan 2013

Sources Of Uncertainty In Nutrient Sampling Below A Point Source, Hayden Campbell

Biology Posters

No abstract provided.

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A Spatially Explicit Model To Predict Radiocesium Body Burdens Of White- Tailed Deer On The U.S. Department Of Energy's Savannah River Site, Christopher W. Bobryk, Karen F. Gaines, James M. Novak, Susan A. Blas Jan 2013

A Spatially Explicit Model To Predict Radiocesium Body Burdens Of White- Tailed Deer On The U.S. Department Of Energy's Savannah River Site, Christopher W. Bobryk, Karen F. Gaines, James M. Novak, Susan A. Blas

Faculty Research & Creative Activity

We developed a spatially explicit exposure model to interpolate and predict radiocesium (137Cs) body burdens found in white-tailed deer (Odocoileus virginianus) on the U.S. Department of Energy’s (USDOE) Savannah River Site (SRS) to gain insight into and differentiate between the main contributing sources of this radionuclide for use in harvest management strategies that focus on minimizing human risk. Hunting has been allowed from permanent stands as a mechanism to manage the deer herd since 1965. All animals are monitored in the field for gross beta and gamma activity levels, providing a spatially explicit dataset. The models described here use the …

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Isoform-Specific Effects Of Apoe On Neurite Outgrowth In Olfactory Epithelium Culture, Aseem Hussain, Minh Luong, Apryl Pooley, Britto P. Nathan Jan 2013

Isoform-Specific Effects Of Apoe On Neurite Outgrowth In Olfactory Epithelium Culture, Aseem Hussain, Minh Luong, Apryl Pooley, Britto P. Nathan

Faculty Research & Creative Activity

The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).

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Diapause And Anhydrobiosis In Embryos Of Artemia Franciscana: Metabolic Depression, Lea Proteins And Water Stress, Steven C. Handel, Yuvraj Patil, Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael A. Menze, Leaf C. Boswell, Daniel Moore, Mehmet Toner Jan 2013

Diapause And Anhydrobiosis In Embryos Of Artemia Franciscana: Metabolic Depression, Lea Proteins And Water Stress, Steven C. Handel, Yuvraj Patil, Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael A. Menze, Leaf C. Boswell, Daniel Moore, Mehmet Toner

Faculty Research & Creative Activity

Metabolic depression is typically correlated with extended survival of environmental challenge and energy-limitation in early life stages of various invertebrates and vertebrates. Diapause is an ontogenetically-programmed reduction of development and often metabolism seen in many invertebrates. When embryos of Artemia franciscana enter the state of diapause, the overall metabolic depression is estimated to be greater than 99%. These embryos also contain trehalose and express multiple isoforms of Late Embryogenesis Abundant (LEA) proteins, constituents often present in a number of such anhydrobiotic animals. The mRNA levels for LEA proteins are highest in diapause and post-diapause embryos that possess desiccation tolerance, but …

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Comparative Anatomy And Dorsal Fin Muscle Activity During Turning Maneuvers In Two Shark Species, Anabela Maia, Cheryl Wilga Jan 2013

Comparative Anatomy And Dorsal Fin Muscle Activity During Turning Maneuvers In Two Shark Species, Anabela Maia, Cheryl Wilga

Faculty Research & Creative Activity

Stability and procured instability characterize two opposing types of swimming, steady and maneuvering, respectively. Fins can be used to manipulate flow to adjust stability during swimming maneuvers either actively using muscle control or passively by structural control. The function of the dorsal fins during turning maneuvering in two shark species with different swimming modes is investigated here using musculoskeletal anatomy and muscle function. White-spotted bamboo sharks are a benthic species that inhabits complex reef habitats and thus have high requirements for maneuverability. Spiny dogfish occupy a variety of coastal and continental shelf habitats and spend relatively more time cruising in …

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Isoform-Specific Effects Of Apoe On Neurite Outgrowth In Olfactory Epithelium Culture, Aseem Hussain, Minh Luong, Apryl Pooley, Britto Nathan Jan 2013

Isoform-Specific Effects Of Apoe On Neurite Outgrowth In Olfactory Epithelium Culture, Aseem Hussain, Minh Luong, Apryl Pooley, Britto Nathan

Faculty Research & Creative Activity

The apolipoprotein E4 (apoE4) genotype is a major risk factor for developing late-onset Alzheimer’s disease (AD). Inheritance of apoE4 is also associated with impairments in olfactory function in early stages of AD. In this project we examined the effects of the three common isoforms of human apoE (apoE2, apoE3, and apoE4) on neuronal differentiation and neurite outgrowth in explant cultures of mouse olfactory epithelium (OE).

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A Novel Reproductive Peptide, Phoenixin, G. L.C. Yosten, R. M. Lyu, A. J.W. Hsueh, O. Avsian-Kretchmer, J. K. Chang, C. W. Tullock, S. L. Dun, N. Dun, W. K. Samson Jan 2013

A Novel Reproductive Peptide, Phoenixin, G. L.C. Yosten, R. M. Lyu, A. J.W. Hsueh, O. Avsian-Kretchmer, J. K. Chang, C. W. Tullock, S. L. Dun, N. Dun, W. K. Samson

Biological Sciences Faculty Research & Creative Works

Normal anterior pituitary function is essential for fertility. Release from the gland of the reproductive hormones luteinising hormone and follicle-stimulating hormone is regulated primarily by hypothalamically-derived gonadotrophin-releasing hormone (GnRH), although other releasing factors (RF) have been postulated to exist. Using a bioinformatic approach, we have identified a novel peptide, phoenixin, that regulates pituitary gonadotrophin secretion by modulating the expression of the GnRH receptor, an action with physiologically relevant consequences. Compromise of phoenixin in vivo using small interfering RNA resulted in the delayed appearance of oestrus and a reduction in GnRH receptor expression in the pituitary. Phoenixin may represent a new …

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Association Of Spirochetal Infection With Morgellons Disease, Marianne J. Middelveen, Divya Burugu, Akhila Poruri, Jennie Burke, Peter J. Mayne, Eva Sapi, Douglas G. Kahn, Raphael B. Stricker Jan 2013

Association Of Spirochetal Infection With Morgellons Disease, Marianne J. Middelveen, Divya Burugu, Akhila Poruri, Jennie Burke, Peter J. Mayne, Eva Sapi, Douglas G. Kahn, Raphael B. Stricker

Biology and Environmental Science Faculty Publications

Morgellons disease (MD) is an emerging multisystem illness characterized by skin lesions with unusual filaments embedded in or projecting from epithelial tissue. Filament formation results from abnormal keratin and collagen expression by epithelial-based keratinocytes and fibroblasts. Recent research comparing MD to bovine digital dermatitis, an animal infectious disease with similar skin features, provided clues that spirochetal infection could play an important role in the human disease as it does in the animal illness. Based on histological staining, immunofluorescent staining, electron microscopic imaging and polymerase chain reaction, we report the detection of Borrelia spirochetes in dermatological tissue of four randomly-selected MD …

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Improved Culture Conditions For The Growth And Detection Of Borrelia From Human Serum, Eva Sapi, Namrata Pabbati, Akshita Datar, Ellen M. Davies, Amy Rattelle, Bruce A. Kuo Jan 2013

Improved Culture Conditions For The Growth And Detection Of Borrelia From Human Serum, Eva Sapi, Namrata Pabbati, Akshita Datar, Ellen M. Davies, Amy Rattelle, Bruce A. Kuo

Biology and Environmental Science Faculty Publications

In this report we present a method to cultivate Borrelia spirochetes from human serum samples with high efficiency. This method incorporates improved sample collection, optimization of culture media and use of matrix protein. The method was first optimized utilizing Borrelia laboratory strains, and later by demonstrating growth of Borrelia from sera from fifty seropositive Lyme disease patients followed by another cohort of 72 Lyme disease patients, all of whom satisfied the strict CDC surveillance case definition for Lyme disease. The procedure resulted in positive cultures in 47% at 6 days and 94% at week 16. Negative controls included 48 cases. …

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Hydraphiles: A Rigorously Studied Class Of Synthetic Channel Compounds With In Vivo Activity, Saeedeh Negin, Bryan Smith, Alexandra Unger, W. Leevy, George Gokel Jan 2013

Hydraphiles: A Rigorously Studied Class Of Synthetic Channel Compounds With In Vivo Activity, Saeedeh Negin, Bryan Smith, Alexandra Unger, W. Leevy, George Gokel

Chemistry & Biochemistry Faculty Works

No abstract provided.

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Evolutionary Biology For The 21st Century, Robert Ricklefs, Jonathan Losos, Stevan Arnold, Gill Bejerano, E. Brodie Iii, David Hibbett, Hopi Hoekstra, David Mindell, Antonia Monteiro, Craig Moritz, H. Orr, Dmitri Petrov, Susanne Renner, Pamela Soltis, Thomas Turner Jan 2013

Evolutionary Biology For The 21st Century, Robert Ricklefs, Jonathan Losos, Stevan Arnold, Gill Bejerano, E. Brodie Iii, David Hibbett, Hopi Hoekstra, David Mindell, Antonia Monteiro, Craig Moritz, H. Orr, Dmitri Petrov, Susanne Renner, Pamela Soltis, Thomas Turner

Biology Department Faculty Works

No abstract provided.

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