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Articles 151 - 180 of 249
Full-Text Articles in Biology
In Silico Pharmacokinetic And Molecular Docking Studies Of N-Cinnamoyltetraketide Derivatives As Inhibitors Of Cyclooxygenase-2 Enzyme, Stephen S. Nyandoro, Daniel M. Shadrack, Joan J. E. Munissi, Egid B. Mubofu
In Silico Pharmacokinetic And Molecular Docking Studies Of N-Cinnamoyltetraketide Derivatives As Inhibitors Of Cyclooxygenase-2 Enzyme, Stephen S. Nyandoro, Daniel M. Shadrack, Joan J. E. Munissi, Egid B. Mubofu
Tanzania Journal of Science
Recent phytochemical analysis of Toussaintia orientalis leaves yielded series of novel bioactive N-cinnamoyltetraketide derivatives namely toussaintines A-G (t_1 - t_8) some portraying cytotoxicity against the triple negative aggressive human breast cancer cell line (MDA-MB-231) among other potencies. Despite having broad bioactivity spectrum, their general drug-likeness profiles and mode of action (simulated or actual) targeting any enzyme remains uninvestigated. In silico pharmacokinetic, drug-likeness descriptors and molecular docking of the compounds t_1-t_8 targeting inhibition of cyclooxygenase-2 (COX-2) enzyme were evaluated. The Lipinski Rule of Five heralded the pharmacokinetic properties of the studied metabolites. The studied compounds were docked with COX-2 following already …
In Vivo Antimycobacterial Studies Of Toussaintine A-Chitosan Nanocomposites, Edward Rwegasila, Joan J.E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro, Paul Erasto
In Vivo Antimycobacterial Studies Of Toussaintine A-Chitosan Nanocomposites, Edward Rwegasila, Joan J.E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro, Paul Erasto
Tanzania Journal of Science
Chitosan (CS, molecular weight (MW) 20.2 kDA, stability of 210 °C and degree of deacetylation (DD) 73.31%) was obtained by deacetylation of chitin extracted from shrimp (Litopenaeus vannamei) shell wastes. The encapsulation of the studied bioactive natural product, toussaintine A (TA) isolated from the leaves of Toussaintia orientalis, on a chitosan-tripolyphosphate (CS/TPP) nanoformulation was attained through ionotropic gelation. Characterization of pure CS, CS/TPP and TA-CS/TPP nanocomposites was carried out by FTIR and SEM. The encapsulation efficiency and loading capacity of the TA were 69.33 and 0.46%, respectively. The in vitro release kinetics established an initial release of 27% of TA …
In Vivo Antimycobacterial Studies Of Toussaintine A-Chitosan Nanocomposites, Edward Rwegasila, Joan J.E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro, Paul Erasto
In Vivo Antimycobacterial Studies Of Toussaintine A-Chitosan Nanocomposites, Edward Rwegasila, Joan J.E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro, Paul Erasto
Tanzania Journal of Science
Chitosan (CS, molecular weight (MW) 20.2 kDA, stability of 210 °C and degree of deacetylation (DD) 73.31%) was obtained by deacetylation of chitin extracted from shrimp (Litopenaeus vannamei) shell wastes. The encapsulation of the studied bioactive natural product, toussaintine A (TA) isolated from the leaves of Toussaintia orientalis, on a chitosan-tripolyphosphate (CS/TPP) nanoformulation was attained through ionotropic gelation. Characterization of pure CS, CS/TPP and TA-CS/TPP nanocomposites was carried out by FTIR and SEM. The encapsulation efficiency and loading capacity of the TA were 69.33 and 0.46%, respectively. The in vitro release kinetics established an initial release of 27% of TA …
Inventory Of The Genus Craterellus Persoon From Kigoma Region, Tanzania, Donatha D Tibuhwa
Inventory Of The Genus Craterellus Persoon From Kigoma Region, Tanzania, Donatha D Tibuhwa
Tanzania Journal of Science
There is scanty knowledge on macro fungi diversity in Kigoma region. Bioprospecting survey was undertaken in Miombo woodlands, Kigoma region of Tanzania that has never been explored. The survey sought to conduct an inventory of Craterellus Persoon. Conventional taxonomic techniques were used during the survey to characterize the collected materials. Both macro and micro morphological features including basidiocarp size, colour, shape, spore size and print colour were examined. High diversity of reputed macrofungi was observed. This study presents a preliminary inventory of the genus Craterellus Persoon in the country. Three species were described; two namely Craterellus cornucopioides (Linnaeus) Persoon and …
The Influence Of Agricultural Activities On The Diversity Of Rodents In Kindoroko Forest Reserve And Surrounding Areas, North Pare Mountains, Tanzania, Remmy Lema, Flora J Magige
The Influence Of Agricultural Activities On The Diversity Of Rodents In Kindoroko Forest Reserve And Surrounding Areas, North Pare Mountains, Tanzania, Remmy Lema, Flora J Magige
Tanzania Journal of Science
The patterns of richness, diversity and similarity in rodent communities in agricultural areas and in adjacent Kindoroko Forest Reserve in the North Pare Mountains, Tanzania were assessed. By using a capture-mark-recapture method, 289 individuals of nine rodent species in March and May 2011 were captured. Seven species were recorded in agricultural area and 5 species in the Forest Reserve. Multimammate Rat (Mastomys natalensis) was abundant in agricultural area while soft-furred mouse (Praomys delectorum) was dominant in the Forest Reserve. Species diversity was greater outside than inside the forest, supporting results of earlier studies. Species similarity between the two habitats was …
Distribution Patterns Of Gastrointestinal Parasites In Vervet Monkeys (Chlorocebus Pygerythrus) At Gombe National Park, Tanzania, Jared S. Bakuza
Distribution Patterns Of Gastrointestinal Parasites In Vervet Monkeys (Chlorocebus Pygerythrus) At Gombe National Park, Tanzania, Jared S. Bakuza
Tanzania Journal of Science
Vervet monkeys at Gombe National Park in western Tanzania constitute a key component of the park’s ecosystem through interactions with other animals and people in the area. However, the parasite fauna of these animals has not been investigated. Thus, 21 faecal samples obtained from the animals in September 2010 were examined for parasites using formol-ethyl technique. The parasites observed included Trichuris spp., Physaloptera spp., hookworms and unidentified nematodes. While egg counts for unidentified nematodes did not vary with vervet monkey communities (z = 0.759, p = 0.448), other parasites were significantly higher among vervets at north of the park near …
In Vitro Antimicrobial Activity Of Extracts Of Some Plant Species Used In The Management Of Hiv/Aids In Tanzania, Cyprian Beda Mpinda, Debra Meyer, Sylvester Leonard Lyantagaye
In Vitro Antimicrobial Activity Of Extracts Of Some Plant Species Used In The Management Of Hiv/Aids In Tanzania, Cyprian Beda Mpinda, Debra Meyer, Sylvester Leonard Lyantagaye
Tanzania Journal of Science
Six plants species (Harungana madagascariensis, Sapium ellipticum, Teclea nobilis, Pseudospondias microcarpa, Rauvolfia vomitoria and Psorospermum febrifugum) which are used in managing HIV/AIDS in Bukoba, Tanzania were screened for their antimicrobial effect on the selected representatives of infectious bacterial and fungal species. Gram-positive bacteria Streptococcus lactis, Gram-negative bacteria Klebsiella pneumoniae and a fungus Candida albicans were tested for their sensitivity to the treatment with selected plants extracts using disc diffusion and broth dilution techniques. Extracts of S. ellipticum, P. febrifegum and P. microcarpa demonstrated growth inhibition of S. lactis with the MIC ranging from 3.2 to 100 mg/ml. The extracts of …
Diet Composition Of The Golden Jackal (Canis Aureus) In The Ngorongoro Crater, Tanzania, Se Temu, Cuthbert L Nahonyo, Pd Moehlman
Diet Composition Of The Golden Jackal (Canis Aureus) In The Ngorongoro Crater, Tanzania, Se Temu, Cuthbert L Nahonyo, Pd Moehlman
Tanzania Journal of Science
The Ngorongoro crater is known for having the highest density of carnivores in the world. In the past, most of the research focused on large carnivores such as lions and spotted hyenas. Medium sized carnivores such as jackals have received very little attention and the information on these carnivores including their diet composition is limited. Diet composition of golden jackal(Canis aureus) was studied in the Ngorongoro crater from July 2014 to May 2015 covering both dry and wet seasons using focal animal observation (direct method) and collection (and analysis) of faecal/scat samples from known individuals in the field (indirect method). …
The Plant Species Composition, Diversity And Natural Regeneration Of Indigenous Trees In The Disturbed Ruvu South Forest Reserve, Tanzania, Cosmas Mligo
Tanzania Journal of Science
Ruvu Forest Reserve is among coastal forests in Tanzania that has been impacted by the increased anthropogenic activities. It was determined the plant species composition, diversity and indigenous trees regeneration growth size structure in the degraded Ruvu South Forest. Transect method was used to collect data that were treated using t-test. A total of 110 plant species distributed among 38 families were recorded such that Holarrhena pubescens, Hymenocardia ulmoides, Millettia micans, Ochna mossambicensis, Pseudolachnostylis maprouneifolia and Strychnos madagascariensis were the most common trees in moderately disturbed site, whereas Albizia versicolor, Pteleopsis myrtifolia, Pterocarpus angolensis, Antiaris toxicaria, Diplorhynchus condylocarpon and Terminalia …
Effect Of Habitat Fragmentation On Diversity And Abundance Of Nesting Birds In An Urban Landscape: The Case Of Mwalimu Nyerere Campus Thickets, University Of Dar Es Salaam, Tanzania, John Shirima, Chacha Werema
Effect Of Habitat Fragmentation On Diversity And Abundance Of Nesting Birds In An Urban Landscape: The Case Of Mwalimu Nyerere Campus Thickets, University Of Dar Es Salaam, Tanzania, John Shirima, Chacha Werema
Tanzania Journal of Science
Little is known of the nesting bird species in most of urban areas of East Africa. An investigation was made of the occurrence of breeding bird species in the fragmented thickets found in the Mwalimu Nyerere Campus of the University of Dar es Salaam, in the City of Dar es Salaam. The study examined how habitat fragmentation affects nesting bird species richness and diversity in the thickets. Systematic physical nest searches of breeding birds were conducted in the fragmented thickets. Searches were conducted in transects and they included inspecting vegetation, bare ground, cavities, stream (river) banks and other suitable nesting …
Design Of A Small Scale Wind Generator For Low Wind Speed Areas, Ra Msuya, Rrm Kainkwa, Mi Mgwatu
Design Of A Small Scale Wind Generator For Low Wind Speed Areas, Ra Msuya, Rrm Kainkwa, Mi Mgwatu
Tanzania Journal of Science
Most small scale level wind turbine generators are directly driven system, variable speed, and partially connected power electronic converter system. Choice of such system is to avoid costs associated with gearbox. However, due to low wind speed in most of the tropical countries, synchronous generators with smaller or medium speed Permanent Magnet (PM) generator design found to be important and given high performance efficiency. In order to be able to harvest wind energy in off-grid population efficiently, there was a need to design a synchronous generator that can be able to operate under low wind speed, directly connected to the …
Cytotoxicity, Antimicrobial And Antioxidant Activities Of Boletus Bicolor, A Basidiomycetes Mushroom Indigenous To Tanzania, Donatha Tibuhwa
Cytotoxicity, Antimicrobial And Antioxidant Activities Of Boletus Bicolor, A Basidiomycetes Mushroom Indigenous To Tanzania, Donatha Tibuhwa
Tanzania Journal of Science
Boletus bicolor commonly known as coloured bolete is a basidiomyctes mushroom species widely used as a delicacy and its extract has been used traditionally to treat several human ailments in Tanzania. This study evaluates its extracts in order to provide a scientific foundation on the possible application in folk medicine system based on the biochemical evaluation. Standard microbes Bacillus subtilis and Candida albicans were used to test, the antifungal and antibacterial activity. Cytotoxicity test was also done on the extracts using brine shrimp test. Besides, the extracts were also used to investigate for antioxidant activity using DPPH (1, 1-diphenyl-2-picrylhydrazyl radical). …
A Comparative Study Of Species Diversity Of Migrant Birds Between Protected And Unprotected Areas Of The Hadejia-Nguru Wetlands, Nigeria, As Ringim, Fj Magige, Rm Jasson
A Comparative Study Of Species Diversity Of Migrant Birds Between Protected And Unprotected Areas Of The Hadejia-Nguru Wetlands, Nigeria, As Ringim, Fj Magige, Rm Jasson
Tanzania Journal of Science
Among the most complex and fascinating behaviour in birds is their long, non-stop migration. Despite Hadejia-Nguru Wetlands (Ramsar site) being an important wintering ground for migratory birds, little is known about the diversity while density is completely lacking. This study assessed the status of migratory birds in the wetland’s Protected Areas (PAs) and Unprotected Areas (UPAs). A total of 99 census points spaced 400 m apart with radius of 100 m were surveyed from 14 wetlands (48 point count stations in the PAs and 51 in the UPAs). A total of 54 migrant bird species belonging to 13 orders and …
Conservation Efforts Of Kihansi Spray Toad Nectophrynoides Asperginis: Its Discovery, Captive Breeding, Extinction In The Wild And Re-Introduction, Cuthbert Nahonyo, Ezekiel Goboro, Wilirk Ngalason, Severinus Mutagwaba, Ichard Ugomba, Mohammed Nassoro, Emmanuel Nkombe
Conservation Efforts Of Kihansi Spray Toad Nectophrynoides Asperginis: Its Discovery, Captive Breeding, Extinction In The Wild And Re-Introduction, Cuthbert Nahonyo, Ezekiel Goboro, Wilirk Ngalason, Severinus Mutagwaba, Ichard Ugomba, Mohammed Nassoro, Emmanuel Nkombe
Tanzania Journal of Science
Species conservation depends on the initiatives to restore or retain and sustainably use the environment in which the species live. This paper highlights how development projects can affect biodiversity conservation and the challenges in achieving sustainable development. The paper discusses a case study of the Kihansi Spray Toad (KST) (Nectophrynoides asperginis) from its discovery, extinction in the wild, captive breeding and subsequent reintroduction to its native habitat; focusing on events, challenges, approaches in addressing issues, future prospects and achievements in the conservation of this endemic species. There has been considerable success in KST husbandry in captivity and reintroduction trials of …
Effect Of Natural Blue-Green Algal Cells Lysis On Freshwater Quality, Kessy Kilulya, Titus Msagati, Bhekie Mamba
Effect Of Natural Blue-Green Algal Cells Lysis On Freshwater Quality, Kessy Kilulya, Titus Msagati, Bhekie Mamba
Tanzania Journal of Science
Blue-green algae grow in freshwater bodies when they are provided with suitable factors such as nutrients and appropriate weather conditions. Their cell lysis occurs naturally when they encounter unfavourable conditions. This study reports on the types and amounts of fatty acids added into freshwater due to the algal cell lysis. The investigation on the amount of fatty acids released into water due to algal cells lysis was performed by placing samples in two compartments, one with no light allowing the algae cells to die while the other compartment was kept in favourable conditions enough to sustain the life of algae. …
Naturally Occurring Mellein-Type 3,4-Dihydroisocoumarins And Related Lactones: Synthetic Approaches - A Review, Stephen Jm Mdachi
Naturally Occurring Mellein-Type 3,4-Dihydroisocoumarins And Related Lactones: Synthetic Approaches - A Review, Stephen Jm Mdachi
Tanzania Journal of Science
Mellein and its derivatives are the most common 3,4-dihydroisocoumarins and are known to exhibit an array of biological activities such as antibacterial, antifungal, antimalarial, antiallergic, antitumor, anti-inflammatory, antiulcer, pheromonal, plant growth-promoting and antileukemic activities. Other mellein derivatives are recognized phytotoxins, neurotoxins, hepatotoxins, nephrotoxins and teratogens. Consequently, considerable efforts have been directed at studying these natural products. While most of the reported studies have focused on the isolation, characterization and bioassay studies of melleins, a number of synthetic studies have also been reported. This paper focuses on synthetic approaches towards these biologically active and, thus, potentially useful natural products. The aim …
Identification Of Tanzanian Saprophytic Edible Mushrooms By Amplification And Sequencing Of Its/Lsu Regions Of Ribosomal Rna Operon, Ibrahim Juma, Anthony Manoni Mshandete, Donatha Damiani Tibuhwa, Amelia Kajumulo Kivaisi
Identification Of Tanzanian Saprophytic Edible Mushrooms By Amplification And Sequencing Of Its/Lsu Regions Of Ribosomal Rna Operon, Ibrahim Juma, Anthony Manoni Mshandete, Donatha Damiani Tibuhwa, Amelia Kajumulo Kivaisi
Tanzania Journal of Science
In this study, ten wild saprophytic edible mushrooms samples, collected from Tanzania natural forests and planted trees, and their two domesticated forms were characterized by in-vitro/in-vivo amplification and sequencing of ITS/LSU regions. Mushroom genomic DNA was extracted by ZR Fungal/Bacterial DNA MniPrep Kit. ITS and LSU regions were amplified using ITS-4/ITS-5 and LR16/LROR primers, respectively and sequenced. The amplicons with messy sequences were cloned. For analyzing recombinant E. coli DH5α cells, colony PCR and sequencing were done using M13-F/M13-R primers. The studied mushrooms were identified as Amylosporus sp. IJ-2014, Polyporales sp., Polyporus tenuiculus, Pleurotus cystidiosus, Laetiporus sp. IJ-2014, Lentinus sajor-caju, …
Spread Of Tylodelphys Mashonense (Digenea: Diplostomidae) By Grey Heron Ardea Cinerea And Great White Egret A. Alba In Lake Victoria, Tanzania, Fred D. Chibwana, Gamba Nkwengulila
Spread Of Tylodelphys Mashonense (Digenea: Diplostomidae) By Grey Heron Ardea Cinerea And Great White Egret A. Alba In Lake Victoria, Tanzania, Fred D. Chibwana, Gamba Nkwengulila
Tanzania Journal of Science
Despite the fact that Tylodelphys mashonense, parasites of the cranial cavity of the catfish Clarias gariepinus, are ubiquitous in freshwater systems, little is known on their spread. As such, we examined a total of 152 piscivorous birds, belonging to 6 species; 43 great cormorant Phalacrocorax carbo, 33 grey heron Ardea cinerea, 26 hamerkop Scopus umbretta, 22 great white egret Ardea alba, 15 marabou stork Leptoptilos crumeniferus and 13 pied kingfisher Ceryle rudis foraging in the Lake Victoria. Out of the six bird species only A. cinerea and A. alba were found infected by T. mashonense with prevalence of 42.4% and …
Variation Of Small Mammal Populations Across Different Habitat Types In The Serengeti Ecosystem, Flora J Magige
Variation Of Small Mammal Populations Across Different Habitat Types In The Serengeti Ecosystem, Flora J Magige
Tanzania Journal of Science
This study investigated the abundance and diversity of small mammals in cultivated land (unprotected area) and wooded grassland in the Serengeti National Park (protected area) in the Serengeti ecosystem. Small mammal populations were sampled through capture-mark-recapture trapping techniques in March-April 2010. A total of 896 trap nights covering wet season, 9 species of rodents and 1 species of soricomorphs (shrew family) were captured. Overall, Multimammate rat Mastomys natalensis (Smith) was by far the most abundant rodent in cultivated land (28%) while inside the park, shrew Crocidura sp., was high in numbers (8%). A significantly higher abundance (trap success) of small …
Ligninolytic Enzymes Of The Fungus Isolated From Soil Contaminated With Cow Dung, Rose J. Masalu
Ligninolytic Enzymes Of The Fungus Isolated From Soil Contaminated With Cow Dung, Rose J. Masalu
Tanzania Journal of Science
Lignin is the complex polymer and very few microorganisms are able to degrade it. The study aimed at isolating lignin degrading fungi from soil contaminated with cow dung using ligninolytic screening media. The study was able to isolate one ligninolytic fungus by using lignin media. The strain was screened for production of ligninolytic enzymes using Rhemazol Brilliant blue R (RBBR) dye, 2,2-azino-bis (3- ethylbenzthiazoline)-6-sulfonate (ABTS) and guaiacol in a semi-solid medium. The isolate decolourized RBBR dye, ABTS and guaiacol in a semi solid media. The strain was further tested for lignin peroxidase (LiP), manganese peroxidase (MnP) and laccase (Lac) enzymatic …
Traditional Medicinal Uses Of Small Mammal Products: A Case Study Of The African Savannah Hares, Crested Porcupines And Rock Hyraxes In Serengeti District, Tanzania, Flora John Magige
Traditional Medicinal Uses Of Small Mammal Products: A Case Study Of The African Savannah Hares, Crested Porcupines And Rock Hyraxes In Serengeti District, Tanzania, Flora John Magige
Tanzania Journal of Science
Traditional medicines, both plant and animal products, have been used to cure various diseases since time immemorial especially in rural areas worldwide. Many studies have focused on traditional plant products, but little research has been conducted on animal traditional medicines. This study investigated the use of small mammal products for medicinal purposes in three villages bordering Serengeti National Park in Serengeti District, Tanzania. A total of 71 respondents were interviewed in Kisangura, Nyamburi and Machochwe villages in November 2010, using questionnaires. Villagers hunted small mammals mainly by dogs for cultural and ornamental reasons. Products of African savannah hare (Lepus microtis), …
Spatial Patterns Of Zooplankton Distribution And Abundance In Relation To Phytoplankton, Fish Catch And Some Water Quality Parameters At Shirati Bay, Lake Victoria-Tanzania, Revania K. Waya, Samwel M. Limbu, Godfrey W. Ngupula, Chacha J. Mwita, Yunus D. Mgaya
Spatial Patterns Of Zooplankton Distribution And Abundance In Relation To Phytoplankton, Fish Catch And Some Water Quality Parameters At Shirati Bay, Lake Victoria-Tanzania, Revania K. Waya, Samwel M. Limbu, Godfrey W. Ngupula, Chacha J. Mwita, Yunus D. Mgaya
Tanzania Journal of Science
Spatial patterns and abundance of zooplankton in aquatic habitats are important determinants for production of fish species, invertebrates and availability of phytoplankton. Weekly monitoring for zooplankton abundance was conducted in Shirati Bay, Lake Victoria, to explore their spatial patterns in relation to phytoplankton, fish catch and some water quality parameters. The vertical distribution of zooplankton was generally higher close to the bottom as compared to surface waters of the lake. Zooplankton vertical distribution positively correlated with water transparency (r = 0.680, p = 0.011). The horizontal abundance of zooplankton was not significantly different amongst the three stations (p = 0.5143). …
Analysis Of Body Shapes Among Barbus Trimaculatus, Barbus Paludinosus And Barbus Jacksonii (Actinopterygii: Cyprinidae) From Malagarasi And Pangani River Basins Based On Geometric Morphometric Method, Chacha J. Mwita, B.G. Kamugisha
Analysis Of Body Shapes Among Barbus Trimaculatus, Barbus Paludinosus And Barbus Jacksonii (Actinopterygii: Cyprinidae) From Malagarasi And Pangani River Basins Based On Geometric Morphometric Method, Chacha J. Mwita, B.G. Kamugisha
Tanzania Journal of Science
This study analyzed variability in body shapes among the small Barbus species of the family Cyprinidae currently occurring in the Malagarasi and Pangani River basins years after uplift of the east African topology. Fish specimens were collected from Songati, Muumbara and Nyamagoma within the Malagarasi River basin; Hale and Pangani fall located on Pangani River. It was found that although the landmarks were placed at the same anatomical regions, significant body shapes variations existed. The relative warps analysis for Barbus trimaculatus and Barbus jacksonii populations from Malagarasi and Pangani wetlands revealed intra-locality variations as for populations from other African countries. …
Formation Of Cell Masses In The Myelencephalon Of The Clawed Frog, Xenopus Muelleri, Flora Stephano
Formation Of Cell Masses In The Myelencephalon Of The Clawed Frog, Xenopus Muelleri, Flora Stephano
Tanzania Journal of Science
An important process in the organization of developing nervous system is the clustering of neurons with similar properties to form nuclei. The development of myelencephalon of Xenopus muelleri, a pipid frog that retains a lateral line system throughout life, was studied in Nissl stained serial sections. The results showed that density of neurons increases as the animal develops. Cell masses were formed in the latter half of larval stages (stage 48 to 59). Large neurons migrate first before small neurons. Raphes and reticular formation nuclei and Mauthner cells were the earliest neurons that could be distinctly recognized on the ventral …
Antimycobacterial And Cytotoxicity Evaluation Of The Constituents Of Monodora Carolinae, Nyangi Magori, Stephen S Nyandoro, Joan Je Munissi, Matthias Heydenreich
Antimycobacterial And Cytotoxicity Evaluation Of The Constituents Of Monodora Carolinae, Nyangi Magori, Stephen S Nyandoro, Joan Je Munissi, Matthias Heydenreich
Tanzania Journal of Science
Phytochemical investigation of the stem bark of the recently described species Monodora carolinae (Annonaceae) afforded prenylindole derivatives (E)-4-(1H-indol-6-yl)-but-3-en-2-one (1), 5-formylindole (2), fatty acid (Z)-hexade-7-enoic acid (3) and the lignanamide cannabisin B (4). The structures of the isolated compounds were established using NMR and MS analyses. The antimycobacterial activities of the extracts and isolated compounds were evaluated against Mycobacterium madagascariense (MM) and M. indicus pranii (MIP) using the two-fold microtitre dilution method. While the extracts exhibited minimum inhibitory concentration (MIC) ranging from 500 – 1000 µg/mL, the isolated compounds were 125 – 250 µg/mL, indicating very low activity. Cytotoxic effects were …
Current Status And Future Perspectives Of Bioinformatics In Tanzania, Sylvester L. Lyantagaye
Current Status And Future Perspectives Of Bioinformatics In Tanzania, Sylvester L. Lyantagaye
Tanzania Journal of Science
The main bottleneck in advancing genomics in present times is the lack of expertise in using bioinformatics tools and approaches for data mining in raw DNA sequences generated by modern high throughput technologies such as next generation sequencing. Although bioinformatics has been making major progress and contributing to the development in the rest of the world, it has still not yet fully integrated the tertiary education and research sector in Tanzania. This review aims to introduce a summary of recent achievements, trends and success stories of application of bioinformatics in biotechnology. The applications of bioinformatics in the fields such as …
Molecularly Imprinted Polymer Technology: A Powerful, Generic, Facile And Cost Effective Alternative For Enantio-Recognition And Separation: A Glance At Advances And Applications, Jyn Philip, Dms Mosha
Molecularly Imprinted Polymer Technology: A Powerful, Generic, Facile And Cost Effective Alternative For Enantio-Recognition And Separation: A Glance At Advances And Applications, Jyn Philip, Dms Mosha
Tanzania Journal of Science
The emerging Molecularly Imprinted Polymer (MIP) technology has yielded proof of concept, harnessing nature’s fundamentals to yield recognition receptor mimics from the miniaturized basics, borrowing on the ground rules, but conveniently avoiding the complexity, fragility, instability, costs and ethics of animal based bio-affinity matrices. Thus, the impact of bio-sciences on the future of technology is not via direct use of the molecules, but rather the lessons learned. Molecular imprinting is a powerful specialty representing the generic, cost effective and facile alternative for preparation of synthetic custom-tailored receptors. It achieves this via creation of specific selective recognition sites for a pre-determined …
New Glucopyranosylglyceryl-N-Octenyl Adipate And Bioactivity Of Retro And Condensed Chalcones From Toussaintia Orientalis, Ss Nyandoro, Mhh , Nkunya, Cc Josepha, Jo Odalo, I Sattler
New Glucopyranosylglyceryl-N-Octenyl Adipate And Bioactivity Of Retro And Condensed Chalcones From Toussaintia Orientalis, Ss Nyandoro, Mhh , Nkunya, Cc Josepha, Jo Odalo, I Sattler
Tanzania Journal of Science
1-(3-β-D-Glucopyranosylglycer-2-yl)-6-N-(oct-2-enyl)-adipate, [orientalin, 1] was isolated as a new metabolite from the polar leaf extracts of Toussaintia orientalis Verdc (Annonaceae), together with the glycoflavonoids afzelin and quercitrin, and the indolidinoids toussaintines A-C. The reversed chalcones 2-hydroxy-3,4,6-trimethoxychalcone (2) and 2-hydroxy-3,4,6- trimethoxydihydrochalcone (3), the condensed chalcone (+)-6a,12a-dihydro-6-phenyl-7-styryl- 6H,7H-[1]benzopyrano[4,3-][l]benzopyran (4), and mixtures of known triterpenoids and steroids were isolated from the less polar extracts of the root and stem bark of the same plant. The structures were established upon detailed analysis of spectroscopic data and other physical parameters. The chalcones exhibited antimicrobial, anti-inflammatory, antiproliferative and cytotoxic activity at varying efficacy levels, the reversed chalcone …
Composition Of Non Volatile Oils And Antimicrobial Activities Of Extracts From Monanthotaxis Discolor, And An Undescribed Uvariondedron Species, Ds Parmena, Ca Mgina, Cc Joseph
Composition Of Non Volatile Oils And Antimicrobial Activities Of Extracts From Monanthotaxis Discolor, And An Undescribed Uvariondedron Species, Ds Parmena, Ca Mgina, Cc Joseph
Tanzania Journal of Science
The chemical compositions of non volatile oil extracts from two Annoneceous plant species Monanthotaxis discolor and an undescribed Uvariodendron species which are endemic to Eastern Arc Mountains, Tanzania were determined by GC-MS. The biological activities of extracts and fractionated samples were also determined. Both methanol and dichloromethane extracts of the root bark of M. discolor showed mild antimicrobial activity and had positive brine shrimp test (BST). The BST test for dichloromethane extract of M. discolor root bark were LC50 41.794 μg/ml and that of methanol extract showed LC50 13.560 μg/ml. The petroleum ether and dichloromethane extracts of root bark of …
Activity Of Enzyme Trypsin Immobilized Onto Macroporous Poly(Epoxy-Acrylamide) Cryogel, W Johnson, Ymm Makame
Activity Of Enzyme Trypsin Immobilized Onto Macroporous Poly(Epoxy-Acrylamide) Cryogel, W Johnson, Ymm Makame
Tanzania Journal of Science
Bovine pancreatic trypsin has been covalently immobilized onto monolithic polyacrylamide cryogels with epoxy functionality (Epoxy-MPAAGs). The covalent immobilization of trypsin onto Epoxy-MPAAGs was achieved through incorporation of ethylenediamine-glutaraldehyde spacers on the cryogels’ surfaces. The immobilization yield and the influence of pH and temperature conditions on the activity of the immobilized trypsin were assessed by using the hydrolysis of a low molecular weight substrate, N-α-benzoyl-D, L-arginine-p-nitroanilide (BAPNA). Optimal pH and temperature values of 9 and 50 °C, respectively, were established for both the immobilized trypsin and the free trypsin. Activity measurements from the native trypsin before immobilization and the residual free …