Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- ACT (1)
- AIDS (1)
- CRISPR (1)
- CRISPR/Cas9 (1)
- Cancer (1)
-
- Cas9 (1)
- Cas9/gRNA (1)
- Gene editing (1)
- Gene therapy (1)
- Genetic engineering (1)
- HAART (1)
- HIV (1)
- HIV-1 (1)
- Immunotherapy (1)
- Infectious diseases (1)
- Insulin producing cells (1)
- Nicotine dependence (1)
- Nicotine replacement therapy (1)
- Pandemic (1)
- Recombinant DNA (1)
- Retrovirus (1)
- Stem cells (1)
- T-cell (1)
- Type 1 diabetes (1)
- Vaccine (1)
- Varenicline (1)
- Β-cells (1)
Articles 1 - 4 of 4
Full-Text Articles in Biology
Smoking Cessation Treatments Varenicline (Chantix®️), Nrts, And Nicotine Dependence, Marley Vea Devoss
Smoking Cessation Treatments Varenicline (Chantix®️), Nrts, And Nicotine Dependence, Marley Vea Devoss
Biology: Student Scholarship & Creative Works
Varenicline was approved in 2006 by the FDA as an effective smoking cessation drug. Varenicline was designed to bind with α4β2 nicotinic acetylcholine receptors (nAChR) to work as both an agonist and antagonist. Other drugs like nicotine replacement therapies (NRTs) have also contributed to the decreasing rate of active smokers in the United States. The mechanisms of varenicline and its role in addiction are reviewed in this paper. With NRTs and recent trends in electronic smoking devices, nicotine dependence is still a cause for concern due to studies connecting nicotine with cell proliferation and heart disease.
Stem Cell Generated Β-Cells: A Possible Solution To The Growing Problem Of Type 1 Diabetes, Danielle Rae Steffen
Stem Cell Generated Β-Cells: A Possible Solution To The Growing Problem Of Type 1 Diabetes, Danielle Rae Steffen
Biology: Student Scholarship & Creative Works
Type 1 diabetes is a growing problem throughout the world. At this time, there is no functional cure, only various treatment options. However, in recent years there has been a significant increase in both the quantity and quality of research into potential cures for type 1 diabetes. This has led to a variety of new possibilities, the most promising of which are β-cells generated from the patient’s own stem cells.
Hiv Vaccines: Progress, Limitations And A Crispr/Cas9 Vaccine, Omar A. Garcia Martinez
Hiv Vaccines: Progress, Limitations And A Crispr/Cas9 Vaccine, Omar A. Garcia Martinez
Biology: Student Scholarship & Creative Works
ABSTRACT: The HIV-1 pandemic continues to thrive due to ineffective HIV-1 vaccines. Historically, the world’s most infectious diseases, such as polio and smallpox, have been eradicated or have come close to eradication due to the advent of effective vaccines. Highly active antiretroviral therapy is able to delay the onset of AIDS but can neither rid the body of HIV-1 proviral DNA nor prevent further transmission. A prophylactic vaccine that prevents the various mechanisms HIV-1 has to evade and attack our immune system is needed to end the HIV-1 pandemic. Recent advances in engineered nuclease systems, like the CRISPR/Cas9 system, have …
Challenges Of Adoptive (T-)Cell Transfer Immunotherapy For Cancer, Aaron Volk
Challenges Of Adoptive (T-)Cell Transfer Immunotherapy For Cancer, Aaron Volk
Biology: Student Scholarship & Creative Works
Background and significance: The rebirth of the theory of immunosurveillance in 2001 rejuvenated interest in anticancer immunotherapies. In particular, T-cell-based therapies have garnered substantial interest due to the robustness and tumor antigen-specific cytotoxicity of T-cell anticancer immune responses.
Hypothesis: The efficacy of adoptive cell transfer (ACT) T-cell immunotherapy could significantly improve and gain widespread approval if future innovations in ACT-based approaches account for the pro- and antitumoral properties of non-CD8+ lineages of effector T-cells, evasion of T-cell antitumor immunity, and tumor-induced suppression of antitumor immunity.
Problem Analysis: Despite numerous reports of highly successful ACT-based clinical trials, no such therapy …