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Articles 1 - 14 of 14
Full-Text Articles in Other Biochemistry, Biophysics, and Structural Biology
Case 59: Inhibition Of Enzymes Involved In Steroid Synthesis: Implications In Diabetes Treatment, Dr. Kathleen Cornely
Case 59: Inhibition Of Enzymes Involved In Steroid Synthesis: Implications In Diabetes Treatment, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
Drugs used to increase insulin sensitivity may also inhibit enzymes involved in steroid synthesis. Prior to this investigation, it was uncertain whether the drugs inhibited the enzymes directly or whether the decrease in androgen synthesis observed during treatment was a secondary effect.
Computational Investigations Into Binding Dynamics Of Tau Protein Antibodies: Using Machine Learning And Biophysical Models To Build A Better Reality, Katherine Lee
University Scholar Projects
Misregulation of post-translational modifications of microtubule-associated protein tau is implicated in several neurodegenerative diseases including Alzheimer’s disease. Hyperphosphorylation of tau promotes aggregation of tau monomers into filaments which are common in tau-associated pathologies. Therefore, tau is a promising target for therapeutics and diagnostics. Recently, high-affinity, high-specificity single-chain variable fragment (scFv) antibodies against pThr-231 tau were generated and the most promising variant (scFv 3.24) displayed 20-fold increased binding affinity to pThr-231 tau compared to the wild-type. The scFv 3.24 variant contained five point mutations, and intriguingly none were in the tau binding site. The increased affinity was hypothesized to occur due …
Case 71: Lactate Dehydrogenase As A Therapeutic Target To Treat Parasitic Disease, Dr. Kathleen Cornely
Case 71: Lactate Dehydrogenase As A Therapeutic Target To Treat Parasitic Disease, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
In this case study, researchers use their knowledge of lactate dehydrogenase in parasites and humans to investigate inhibitors that are selective for the parasite agent.
Case 51: Purification Of A Transferase Involved In The Production Of Physiologically Important Glycoproteins, Dr. Kathleen Cornely
Case 51: Purification Of A Transferase Involved In The Production Of Physiologically Important Glycoproteins, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
A transferase involved in post-translational glycosylation of a physiologically important glycoprotein is purified and characterized.
Case 40: A Collection Of Collagen Cases, Dr. Kathleen Cornely
Case 40: A Collection Of Collagen Cases, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
Factors important in the stability of collagen are examined.
Case 6: Hemoglobin Providence, Dr. Kathleen Cornely
Case 6: Hemoglobin Providence, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
A mutant hemoglobin variant, Hemoglobin Providence, exists in two forms in vivo.
Case 32: Inhibition Of Protein Tyrosine Phosphatase Enzymes As A Possible Treatment For Diabetes, Dr. Kathleen Cornely
Case 32: Inhibition Of Protein Tyrosine Phosphatase Enzymes As A Possible Treatment For Diabetes, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
Protein tyrosine phosphatases (PTPs) are investigated because of their ability to reverse the effects of protein tyrosine kinases (PTKs). Inhibitors of the PTP investigated in this study have insulin-mimetic effects and have potential in the treatment of diabetes.
Case 70: Hemoglobin Mito: A Japanese Hemoglobin Variant With Altered Oxygen Binding Affinity, Dr. Kathleen Cornely
Case 70: Hemoglobin Mito: A Japanese Hemoglobin Variant With Altered Oxygen Binding Affinity, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
In this case study, researchers use their knowledge of hemoglobin structure to predict the oxygen binding properties of a hemoglobin mutant with a single amino acid substitution, then test their hypothesis by studying the mutant’s oxygen binding properties.
Case 34: Kinetics Of Alkaline Phosphatase, Dr. Kathleen Cornely
Case 34: Kinetics Of Alkaline Phosphatase, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
Kinetic studies are carried out using the alkaline phosphatase, an enzyme that has an important role in skeletal mineralization.
Case 67: Phenylalanine Hydroxylase: An Investigation Of Its Structure Leads To The Development Of Pku New Therapies, Dr. Kathleen Cornely
Case 67: Phenylalanine Hydroxylase: An Investigation Of Its Structure Leads To The Development Of Pku New Therapies, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
The characteristics of phenylalanine hydroxylase, the enzyme missing in persons afflicted with the genetic disorder phenylketonuria (PKU), are examined. Understanding how the enzyme works will allow the development of drugs to treat this condition.
Case 64: Alkalosis In A Patient With A Brain Tumor: A Link Between The Cns And Blood Ph, Dr. Kathleen Cornely
Case 64: Alkalosis In A Patient With A Brain Tumor: A Link Between The Cns And Blood Ph, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
The response of the carbonic acid/bicarbonate buffering system to a patient’s hyperventilation–presumably caused by CNS abnormalities following surgery to remove a brain tumor–is examined.
Case 61: Inhibition Of Malarial Aspartate Protease, Dr. Kathleen Cornely
Case 61: Inhibition Of Malarial Aspartate Protease, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
In this case study, students investigate the purification and kinetic properties of a malarial asparate protease.
Molecular Fossils From Phytoplankton Reveal Secular Pco2 Trend Over The Phanerozoic, Caitlyn R. Witkowski, Johan W. H. Weijers, Brian S. Blais, Stefan Schouten, Jaap S. Sinninghe Damsté
Molecular Fossils From Phytoplankton Reveal Secular Pco2 Trend Over The Phanerozoic, Caitlyn R. Witkowski, Johan W. H. Weijers, Brian S. Blais, Stefan Schouten, Jaap S. Sinninghe Damsté
Science and Technology Department Faculty Journal Articles
Past changes in the atmospheric concentration of carbon dioxide (PCO2) have had a major impact on earth system dynamics; yet, reconstructing secular trends of past PCO2 remains a prevalent challenge in paleoclimate studies. The current long-term PCO2reconstructions rely largely on the compilation of many different proxies, often with discrepancies among proxies, particularly for periods older than 100 million years (Ma). Here, we reconstructed Phanerozoic PCO2 from a single proxy: the stable carbon isotopic fractionation associated with photosynthesis (Ɛp) that increases as PCO2 increases. This concept has been widely applied to alkenones, but here, we …
Case 62: Glycolysis, The Pentose Phosphate Pathway, And The Citric Acid Cycle In Tumorigenesis, Dr. Kathleen Cornely
Case 62: Glycolysis, The Pentose Phosphate Pathway, And The Citric Acid Cycle In Tumorigenesis, Dr. Kathleen Cornely
Chemistry & Biochemistry Case Studies
Hypoxia-inducible factors are transcription factors that mediate the cellular response to hypoxia (low cellular oxygen concentration) by enhancing or suppressing the transcription of specific genes involved in metabolic pathways.