Biochemistry Commons^™

The Role Of Protein Kinases Rog1 And Srf6 In The Wak Stress Response Pathway, Jaepil Eric Yoon

Jaepil Eric Yoon

The wall-associated kinases (WAKs) are receptor kinases that bind cell wall pectin to activate expansion and stress response pathways in Arabidopsis thaliana. When bound to pectin polymers, WAKs initiate expansion by inducing the expression of vacuolar invertases that increase cellular turgor pressure, which pushes out against the cell wall. WAKs also bind pathogen or wounding induced pectin fragments called oligogalacturonic acids (OGs). When bound to OGs, WAKs induce a stress response, which leads to the activation of MAP kinases, MPK3 and MPK6. Phosphoproteomics and mass spectrometry identified receptor kinase SRF6, cytoplasmic kinase ROG1, and nuclear DNA binding protein REM2 to …