Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Biochemistry
Studying Potential Drug Interactions Involved In The Regulation Of The Diaphanous-Related Formins, Brittany E. Benson, Bradley J. Wallar
Studying Potential Drug Interactions Involved In The Regulation Of The Diaphanous-Related Formins, Brittany E. Benson, Bradley J. Wallar
Student Summer Scholars Manuscripts
Diaphanous-related formins (DRFs) are a conserved family of proteins that are involved in the regulation of cellular shape, motility, and cell division by regulating the structure of the cellular “skeleton” (cytoskeleton); any disruption of this regulation can result in cell death. Normally, the DRFs are kept in an inactive state by the intramolecular binding of two regions of the protein: the Diaphanous Autoregulatory Domain (DAD) and Diaphanous Inhibitory Domain (DID). This binding can be alleviated by various naturally-occurring mechanisms and proper regulation of the activity of these proteins is vital to cell survival because prolonged activation of DRFs can result …