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Full-Text Articles in Biochemistry
Smart Stimulation: Zoo Conservation For 21st Century Zoos, Lauren Retallack
Smart Stimulation: Zoo Conservation For 21st Century Zoos, Lauren Retallack
WWU Honors College Senior Projects
According to a 1992 survey, "an estimated 102 million people, more than attend professional football, baseball, and basketball games combined, visit 162 accredited North American zoos and aquariums each year" (2). People frequent zoos for a variety of reasons, from entertaining children for a few hours, to learning about the wildlife which inhabits their region and foreign places. Regardless of intent, once at the zoo, visitors are presented with a unique opportunity to learn about conservation and the plights of endangered species. It is the job of zoo directors, keepers, staff, and volunteers to get people thinking about conservation while …
The Tertiary Structure And Domain Organization Of Coagulation Factor Viii, P. Clint Spiegel, Betty W. Shen, Chong-Hwan Chang, Jae-Wook Huh, Jeanman Kim, Young-Ho Kim, Barry L. Stoddard
The Tertiary Structure And Domain Organization Of Coagulation Factor Viii, P. Clint Spiegel, Betty W. Shen, Chong-Hwan Chang, Jae-Wook Huh, Jeanman Kim, Young-Ho Kim, Barry L. Stoddard
Chemistry Faculty and Staff Publications
Factor VIII (fVIII) is a serum protein in the coagulation cascade that nucleates the assembly of a membrane-bound protease complex on the surface of activated platelets at the site of a vascular injury. Hemophilia A is caused by a variety of mutations in the factor VIII gene and typically requires replacement therapy with purified protein. We have determined the structure of a fully active, recombinant form of factor VIII (r-fVIII), which consists of a heterodimer of peptides, respectively containing the A1-A2 and A3-C1-C2 do- mains. The structure permits unambiguous modeling of the relative orientations of the 5 domains of r-fVIII. …