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Full-Text Articles in Biochemistry
Transmembrane Movement Of Exogenous Long-Chain Fatty Acids: Proteins, Enzymes, And Vectorial Esterification, Paul N. Black, Concetta C. Dirusso
Transmembrane Movement Of Exogenous Long-Chain Fatty Acids: Proteins, Enzymes, And Vectorial Esterification, Paul N. Black, Concetta C. Dirusso
Department of Biochemistry: Faculty Publications
INTRODUCTION......................................................................................................................................................454
FATTY ACIDS AND BIOLOGICAL MEMBRANES.............................................................................................455
Fatty Acid Transport Defined ...............................................................................................................................456
MODEL SYSTEMS TO INVESTIGATE FATTY ACID TRANSPORT ..............................................................456
Genetic Foundations of Fatty Acid Transport....................................................................................................456
PROTEINS IMPLICATED IN FATTY ACID TRANSPORT ...............................................................................456
Fatty Acid Translocase..........................................................................................................................................457
Fatty Acid Binding Protein—Membrane Bound ................................................................................................457
Fatty Acid Transport Protein...............................................................................................................................458
The Long-Chain Fatty Acid Transport Protein FadL .......................................................................................458
Fatty Acyl-CoA Synthetase ...................................................................................................................................459
VECTORIAL ACYLATION: ONE MECHANISM OPERATIONAL IN FATTY ACID TRANSPORT...........460
THE BACTERIAL PARADIGM ...............................................................................................................................460
Energetics of Fatty Acid Transport in Gram-Negative Bacteria......................................................................460
The Fatty Acid Transporter FadL........................................................................................................................461
The Fatty Acyl-CoA Synthetase FadD..................................................................................................................461
Structural Considerations of FACS .....................................................................................................................462
FATTY ACID TRANSPORT AND ACTIVATION IN YEAST: …
The Many Faces Of Vitamin B12: Catalysis By Cobalamin-Dependent Enzymes, Ruma Banerjee, Stephen W. Ragsdale
The Many Faces Of Vitamin B12: Catalysis By Cobalamin-Dependent Enzymes, Ruma Banerjee, Stephen W. Ragsdale
Department of Biochemistry: Faculty Publications
Vitamin B12 is a complex organometallic cofactor associated with three subfamilies of enzymes: the adenosylcobalamin-dependent isomerases, the methylcobalamin-dependent methyltransferases, and the dehalogenases. Different chemical aspects of the cofactor are exploited during catalysis by the isomerases and the methyltransferases. Thus, the cobalt-carbon bond ruptures homolytically in the isomerases, whereas it is cleaved heterolytically in the methyltransferases. The reaction mechanism of the dehalogenases, the most recently discovered class of B12 enzymes, is poorly understood. Over the past decade our understanding of the reaction mechanisms of B12 enzymes has been greatly enhanced by the availability of large amounts of enzyme …