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Full-Text Articles in Biochemistry
Probing The Domain Architecture And Structural Dynamics Of Caspase-6 For Its Specific Regulation, Kevin Buadlart Dagbay
Probing The Domain Architecture And Structural Dynamics Of Caspase-6 For Its Specific Regulation, Kevin Buadlart Dagbay
Doctoral Dissertations
Caspases are cysteine aspartate proteases that direct programmed cell death in multicellular organisms. Activation of caspases is tightly regulated to secure maintenance of cellular homeostasis. The aberrant regulation of caspases can act as molecular triggers for a range of diseases from cancer to neurodegeneration. The detailed exploration of caspase structure, dynamics, function, and regulation is crucial to better understand and precisely control their cellular functions. This body of work specifically provides a multi-level understanding of the unique structural dynamics and regulation of caspase-6, the function of which is implicated in Alzheimer’s and Huntington’s diseases. A detailed map …
Exploitation And Regulation Of Apoptotic Caspases, Scott Eron
Exploitation And Regulation Of Apoptotic Caspases, Scott Eron
Doctoral Dissertations
Caspases are the cysteine proteases that govern apoptotic cell death. The regulation of these enzymes is critical in order to restrain their death-inducing capabilities until the appropriate moment. Infidelity of caspase regulation and activation underlies a plethora of human diseases ranging from cancer to neurodegeneration. This establishes a pressing need for comprehensive studies of the apoptotic caspases in order to understand all aspects of their regulation, activation, substrate preferences, structure, and function. A detailed structural view of caspase regulation would have lasting implications for future therapeutic avenues targeting caspase function or apoptosis. This dissertation chronicles caspase regulation by phosphorylation as …