Biochemistry Commons^™

Determining The Role Of Erbeta In The Activation Of Erk1/2 By The Environmental Estrogens, Cadmium Chloride And Sodium Arsenite, In Human Lung Adenocarcinoma Cells, Jeffrey Hyzer

Undergraduate Theses

Estrogen is involved in the proliferation of adenocarcinoma lung cells. However, the proliferative role of two endocrine disrupters, cadmium chloride and sodium arsenite, in lung adenocarcinoma is less clear. Previous studies have shown that these two heavy metals can induce cellular proliferation and activate phosphorylation of ERK1/2 in a human lug adenocarcinoma cell line, NCI-H1793. Induced phosphorylation of ERK1/2 by these compounds is decreased in the presence of an estrogen receptor antagonist, ICI-182,780, suggesting that cadmium and arsenite stimulate these responses, in part, via a non-genomic estrogen signaling pathway. There are three known estrogen receptors, but it is unclear which …