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Characterizing Cyclin J By Identifying Conserved Protein-Protein Interactions, Phillip Jacob Selman
Characterizing Cyclin J By Identifying Conserved Protein-Protein Interactions, Phillip Jacob Selman
Wayne State University Theses
Cyclins are proteins that bind to Cyclin-dependent kinases, or Cdks, through a conserved domain called the Cyclin Box. Many Cyclins regulate the cell cycle. A few Cyclins impact cellular processes outside of the cell cycle. Also, a few Cyclins have poorly understood functions.
Cyclin J is a member of the Cyclin superfamily of proteins. Cyclin J is conserved among all metazoans, but is presently not well understood. All the research done on Cyclin J has been done in Drosophila.
Its mRNA is present in the early embryo, then disappears, only to reappear in adult females. When probing protein extracts with …