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Cysteine Desulfurase And Isd11: A Drosophila Model, Rahul Ravindran Nair
Cysteine Desulfurase And Isd11: A Drosophila Model, Rahul Ravindran Nair
Wayne State University Theses
ABSTRACT
Cysteine desulfurase and Isd11: A Drosophila model
Iron-sulfur clusters are cofactors with evolutionary origins that date back to the pre-biotic world. Ever since life originated, these cofactors have intermingled with proteins to play vital roles in sustaining life. My research focuses on one such protein, the cysteine desulfurase (Nfs) that has the PLP cofactor incorporated in its active site and avails of the catalytic property of PLP to provide sulphur for Iron-sulfur cluster biogenesis and assembly in a cell. Interestingly, in a eukaryotic cell, despite the versatility of PLP, cysteine desulfurase's role as a "sulphur-extractor" is incomplete without another …