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Full-Text Articles in Biochemistry
Studies On The Purification And Role Of Igfbp-5 Protease In Bone, H. Garrett Rush Thompson
Studies On The Purification And Role Of Igfbp-5 Protease In Bone, H. Garrett Rush Thompson
Loma Linda University Electronic Theses, Dissertations & Projects
Osteoporosis is a disease characterized by low bone density and deterioration of mineralized bone leading to enhanced susceptibility to fracture. Several growth factors have been implicated in the coupling of formation to resorption during the bone remodeling process. The net bone forming activity of many growth factors has prompted numerous studies focused on the regulation of osteoblast cell proliferation, differentiation and activity. The current study focuses on the insulin-like growth factor (IGF) system, an important growth factor system involved in the regulation of bone formation and bone resorption.
IGF binding protein -5 (IGFBP-5), the most abundant IGF binding protein in …