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Full-Text Articles in Biochemistry
Functional Analysis Of Bacillus Anthracis Aspartate Transcarbamoylase And Dihydroorotase, Katelyn Leigh Schwager Silva
Functional Analysis Of Bacillus Anthracis Aspartate Transcarbamoylase And Dihydroorotase, Katelyn Leigh Schwager Silva
Wayne State University Theses
There are many enzymes required for efficient and proper pyrimidine biosynthesis. The two that are most important and were discussed in this thesis are aspartate transcarbamoylase (ATCase) and dihydroorotase (DHOase). Both play an important role in not only pyrimidine biosynthesis production, but also mechanistic regulation of de novo synthesis. Anthrax is an infection caused by Bacillus anthracis. Here we studied ATCase and DHOase in Bacillus Anthracis. In this thesis we understood the effects of the enzymes ATCase and DHOase on pyrimidine biosynthesis. Adequate inhibitors of these enzymes would result in cell death and could pose as a cure to infection …
Effect Of Oil Palm Phenolics (Opp) On Pancreatic Cancer Cell Lines, Inaam Abdul Karim
Effect Of Oil Palm Phenolics (Opp) On Pancreatic Cancer Cell Lines, Inaam Abdul Karim
Wayne State University Theses
Pancreatic cancer (paca) is currently the fifth causes of cancer-related deaths in the United States. It’s an aggressive form of cancer with very low survival rates because of delayed diagnosis and limited treatment options. Gemcitabine is the chemotherapy drug that provides minimal benefits along with many side effects. The aim of this study was to examine the in vitro effects of oil palm phenolics (OPP) fraction-5, the water-soluble component of palm oil, in human pancreatic cancer cell models. Two pancreatic cancer cell lines (Panc-1 and BxPC-3) were categorized into control and treatment groups. The control group received cell culture media …