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Full-Text Articles in Biochemistry
Interrogation Of Protein Function With Peptidomimetics, Olapeju Bolarinwa
Interrogation Of Protein Function With Peptidomimetics, Olapeju Bolarinwa
USF Tampa Graduate Theses and Dissertations
Proteins can be described as the “machineries” responsible for almost all tasks in the levels of organizational complexity in multi-cellular organisms namely: the cells, tissues, organs and systems. Any disorder in the function of a protein at any of these levels could result in disease, and a study of protein function is critical to understanding the pathological features of the disease at the molecular level. A quick glance at these abundantly present proteins reveals two striking features: large diversity of biological function, and the variations in structural complexity, which varies from simple random coils, to turns and helices, and on …
Cell Permeability Studies Of Aapeptides And Novel Molecular Probes For Ad, Ge Bai
Cell Permeability Studies Of Aapeptides And Novel Molecular Probes For Ad, Ge Bai
USF Tampa Graduate Theses and Dissertations
Alzheimer's diseases(AD) has been discovered and under research for more than 70 years, However there is no cure for these progressive and devastating diseases. Based on the following hypothsis: Aß metabolite problem/over production result in the accumulation, and lead to aggregation is the cause of Alzheimer’s disease. AApeptide and Melatonin derivatives can bind to Aß and block the aggregation of β amyloid monomers, decrease the toxicity of Aß to neurons and slow the progressive of Alzheimer’s diseases. In addition, AApeptide which mimic transmembrane peptide Tat will have similar transmembrane function. We have set up our goals as follows: 1) Using …