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Full-Text Articles in Biochemistry
A Proximity-Dependent Biotin Labeling Based Screen For Protein Kinase A Anchoring Proteins Within Focal Adhesion Complexes, Hannah Naughton
A Proximity-Dependent Biotin Labeling Based Screen For Protein Kinase A Anchoring Proteins Within Focal Adhesion Complexes, Hannah Naughton
Graduate College Dissertations and Theses
Protein kinase A (PKA) regulates a diverse array of cellular activities including metabolism, differentiation, actomyosin contractility, and migration. The multifunctionality of this ubiquitous enzyme is achieved, in part, through subcellular targeting mediated by the A Kinase Anchoring Proteins (AKAP) family of proteins. AKAPs serve as scaffolding proteins that localize PKA to various cellular compartments and bring together specific targets and modulators of PKA activity.
The importance of spatially restricted PKA signaling is particularly apparent in the context of cell motility. It has been observed that both anchoring through AKAPs and the subsequent localized activation of PKA at the leading edge …