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Full-Text Articles in Biochemistry
Coilin Expression During Nucleolar Stress In The Drosophila Brain, Kathryn Rose Deleo
Coilin Expression During Nucleolar Stress In The Drosophila Brain, Kathryn Rose Deleo
LSU Master's Theses
Impairment of ribosome biogenesis disrupts cellular homeostasis and, in the process, causes a state of nucleolar stress in a cell. This triggers human syndromes collectively known as ribosomopathies. One such ribosomopathy is the Treacher Collins syndrome (TCS) which causes congenital craniofacial birth defects and hearing loss in patients. In TCS migration of neural crest cells during development is hindered by the loss of the ribosome assembly factor, treacle, and consequent apoptosis of these progenitor cells. Modeling this disorder in Drosophila was previously accomplished by disruption of Nopp140, treacle’s closest equivalent in Drosophila. During nucleolar stress, the Mushroom Body neuroblast …