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Full-Text Articles in Biochemistry
Hpv16 E6* Induces Oxidative Stress And Dna Damage, Vonetta M. Williams
Hpv16 E6* Induces Oxidative Stress And Dna Damage, Vonetta M. Williams
Loma Linda University Electronic Theses, Dissertations & Projects
High risk types of Human Papillomavirus are the causative agents of virtually all cases of cervical cancer, 50-90% of other anogenital cancers and approximately 30% of oral and pharyngeal cancers. The high-risk types encode two viral oncogenes, E6 and E7, which work together to initiate cell transformation. The approximately 50 amino acid product of the E6* transcript is expressed during the early stages of HPV infection. In this study, we found that expression of E6* increased the level of reactive oxygen species (ROS) in both HPV+ and HPV- cells. This increased oxidative stress led to higher levels of DNA damage. …