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The Role Of Hsp70 In Cancer: A Study Of The Hsp70 / Akt Relationship, John Koren
The Role Of Hsp70 In Cancer: A Study Of The Hsp70 / Akt Relationship, John Koren
USF Tampa Graduate Theses and Dissertations
The Hsp70 family of molecular chaperones is essential for
protein folding, re-folding misfolded client proteins, clearance
of aberrant client proteins, and can also inhibit programmed
cell death. There are two major cytosolic members of this
family: the constitutive Hsc70, and the inducible Hsp72. Under
stress conditions the Hsp70 family protects the cell from
protein related damage by the induction of Hsp72. Hsc70 and
Hsp72 are highly homologous with minor differences in
substrate binding. In cancers, Hsp72 is commonly induced and
this induction is thought to aid in cancer cell survival. In these
studies we demonstrate the differential regulation of the …