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Full-Text Articles in Biochemistry
Synthetic Dosage Lethality Screen With Actin Cytoskeleton In Yeast, Jessica Cho
Synthetic Dosage Lethality Screen With Actin Cytoskeleton In Yeast, Jessica Cho
Honors Capstone Projects - All
The actin cytoskeleton is a vitally important organizing structure found in the cytoplasm of our cells. It contributes to essential cell functions from growth and cell division, development, signal transduction, adaptation, to gene expression. Interest in how regulation of the actin cytoskeleton---due to actin cytoskeleton's importance to cell function-may contribute to diverse human disease states such as the rampant cell division and metastasis that occurs in cancerous tissues. It has been further elucidated that many human genetic disorders are the result of complex haploinsufficiencies (CHI) and/or altered gene dosages at multiple loci. By reviewing a large number of potential Synthetic …
Germline Cyst Formation And Development In Zebrafish, Tess Cherlin
Germline Cyst Formation And Development In Zebrafish, Tess Cherlin
Honors Capstone Projects - All
In developing pre-natal mice, germline cysts are clusters or packages of cells consisting of individual oocytes. They are formed after the primordial germ cells move to the ovary during embryogenesis. The primordial germ cells divide, but do not completely separate. The cells within the cysts are linked by intercellular bridges, which end up breaking down leading to the formation of primordial follicles. The primordial follicles are oocytes surrounded by somatic cells called granulosa cells. Only one third of the original oocytes survive cyst breakdown and become the eggs that will be used by the mouse for her reproduction. This developmental …