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Articles 1 - 6 of 6
Full-Text Articles in Biochemistry
The Ldl Receptor Clustering Motif Interacts With The Clathrin Terminal Domain In A Reverse Turn Conformation., Richard G. Kibbey, Josep Rizo, Lila Gierasch, Richard G. W. Anderson
The Ldl Receptor Clustering Motif Interacts With The Clathrin Terminal Domain In A Reverse Turn Conformation., Richard G. Kibbey, Josep Rizo, Lila Gierasch, Richard G. W. Anderson
Lila Gierasch
Previously the hexapeptide motif FXNPXY807 in the cytoplasmic tail of the LDL receptor was shown to be essential for clustering in clathrin-coated pits. We used nuclear magnetic resonance line-broadening and transferred nuclear Overhauser effect measurements to identify the molecule in the clathrin lattice that interacts with this hexapeptide, and determined the structure of the bound motif. The wild-type peptide bound in a single conformation with a reverse turn at residues NPVY. Tyr807Ser, a peptide that harbors a mutation that disrupts receptor clustering, displayed markedly reduced interactions. Clustering motif peptides interacted with clathrin cages assembled in the presence or absence of …
Involvement Of Heme In The Degradation Of Iron-Regulatory Protein 2, Lisa Goessling, David Mascotti, Robert Thach
Involvement Of Heme In The Degradation Of Iron-Regulatory Protein 2, Lisa Goessling, David Mascotti, Robert Thach
David P. Mascotti
ron-regulatory proteins (IRPs) recognize and bind to specific RNA structures called iron-responsive elements. Mediation of these binding interactions by iron and iron-containing compounds regulates several post-transcriptional events relevant to iron metabolism. There are two known IRPs, IRP1 and IRP2, both of which can respond to iron fluxes in the cell. There is ample evidence that IRP1 is converted by iron to cytoplasmic aconitase in vivo. It has also been shown that, under certain conditions, a significant fraction of IRP1 is degraded in cells exposed to iron or heme. Studies have shown that the degradation of IRP1 that is induced by …
The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Elizabeth R. Gillard, Arshad M. Khan, Rickinder S. Grewal, Bara Mouradi, Stefany D. Wolfsohn, B. Glenn Stanley
The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Elizabeth R. Gillard, Arshad M. Khan, Rickinder S. Grewal, Bara Mouradi, Stefany D. Wolfsohn, B. Glenn Stanley
Arshad M. Khan, Ph.D.
No abstract provided.
Rna Bulge Entropies Correlate With Peptide Binding Strengths For Hiv-1 And Biv Tar Rna Because Of Improved Conformational Access, Brooke Lustig, I Baharand, R L. Jernigan
Rna Bulge Entropies Correlate With Peptide Binding Strengths For Hiv-1 And Biv Tar Rna Because Of Improved Conformational Access, Brooke Lustig, I Baharand, R L. Jernigan
Brooke S. Lustig
For the binding of peptides to wild-type HIV-1 and BIV TAR RNA and to mutants with bulges of various sizes, changes in the ΔΔG values of binding were determined from experimental Kd values. The corresponding entropies of these bulges are estimated by enumerating all possible RNA bulge conformations on a lattice and then applying the Boltzmann relationship. Independent calculations of entropies from fluctuations are also carried out using the Gaussian network model (GNM) recently introduced for analyzing folded structures. Strong correlations are seen between the changes in free energy determined for binding and the two different unbound entropy calculations. The …
Growth And Reproductive Performance Of Small Ruminants Under Integrated Livestock Oil Palm Production System, Ahmad Salihin Hj Baba, Azillah A., Mukherjee T. K., Abdullah R. B.
Growth And Reproductive Performance Of Small Ruminants Under Integrated Livestock Oil Palm Production System, Ahmad Salihin Hj Baba, Azillah A., Mukherjee T. K., Abdullah R. B.
Ahmad Salihin Hj Baba
The effects of supplementation with mixed fodder or concentrate were investigated on the performance of a) growth of male lambs;md kids grazing extensively under oil palm trees and b) reproduction of ewes and goats stall-fed with native herbage. Supplemented kids and lambs had higher average daily weight gain than controls but the effect was only significant for those which received concentrate (p < 0.05). Final body weight was only significantly different from controls for lambs supplemented with concentrate (p < 0.05). The ages at puberty, first mating, first conception and first kidding of supplemented goats were about 110 days earlier than those for controls (p < 0.05 or better). Supplemented goats had first mating and conceived at lower body weights (p < 0.01) than those in control groups. Different feeding regimes had no effects (p > 0.05) on the reproductive performance of ewes apart fi om highest body weight of first lambing in animals supplemented with concentrate (p < 0.05). Native herbage available under oil palm trees of 5 years old was sufficient for growth …
Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Elizabeth R. Gillard, Arshad M. Khan, Bara Mouradi, Omkar Nalamwar, B. Glenn Stanley
Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Elizabeth R. Gillard, Arshad M. Khan, Bara Mouradi, Omkar Nalamwar, B. Glenn Stanley
Arshad M. Khan, Ph.D.
No abstract provided.