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Articles 1 - 12 of 12
Full-Text Articles in Biochemistry
Cellular Uptake Mechanism Of Paclitaxel Nanocrystals, Iris K. Archer, Zhaohui Wang, Tonglei Li
Cellular Uptake Mechanism Of Paclitaxel Nanocrystals, Iris K. Archer, Zhaohui Wang, Tonglei Li
The Summer Undergraduate Research Fellowship (SURF) Symposium
Therapeutic options for metastasized human cancer in current practice remain limited and, sadly, there is no cure for metastatic cancer. The typical approach, chemotherapy, has both low efficacy due to poor drug solubility, and cytotoxic side effects to healthy tissue when delivered indiscriminately. To address both of these issues, we are pursuing the use of nanocrystal formulations of current chemotherapeutic agents as delivery platforms. Herein, we have studied cellular uptake mechanisms in cancer cells of nanocrystals of a chemotherapeutic agent, paclitaxel. Our goal in this study is to determine whether the nanocrystals can be taken up via endocytosis, especially when …
Identification Of Set1 Target Genes, William Beyer, Scott D. Briggs
Identification Of Set1 Target Genes, William Beyer, Scott D. Briggs
The Summer Undergraduate Research Fellowship (SURF) Symposium
The Set1 complex, a histone methyltransferase complex found in S. cerevisiae (budding yeast), is the only histone methyltransferase responsible for catalyzing methylation of histone H3 at Lysine 4. It possesses homologues in other species, humans included. While yeast only have the Set1 complex, the human homologues of the yeast Set1 complex include mixed-lineage leukemia family (MLL1-4), Set1 A, Set1 B, among others. MLL1-4 has been shown to play a role in transcription, cell type specification, and the development of leukemia. One application of characterizing the role of a protein is that the information gained can provide insight into the function …
Involvement Of Post-Transcriptional Histone Modifications In Chromosome Missegregation, Jessica N. Gabbard, Ann Kirchmaier
Involvement Of Post-Transcriptional Histone Modifications In Chromosome Missegregation, Jessica N. Gabbard, Ann Kirchmaier
The Summer Undergraduate Research Fellowship (SURF) Symposium
Proper chromosome segregation during mitosis ensures the equal inheritance of parental DNA by two daughter cells. Errors in chromosome segregation result in aneuploidy, the inheritance of abnormal chromosome numbers. Aneuploidy is a characteristic of tumors cells; therefore, understanding the factors that cause chromosome missegregation will provide insight into carcinogenesis. Certain post-transcriptional histone modifications in centromeric and pericentromeric regions are associated with maintaining kinetochore integrity and ensuring proper chromosome segregation. However, whether loss or improper distribution of modifications directly or indirectly causes chromosome missegregation is yet to be determined. To compare the DNA content of mutated yeast strains relative to WT, …
Saccharomyces Cerevisiae Cdc7 Homology In Drosophila Melanogaster, Marcus R. Hosler, Robert E. Stephenson, Vikki M. Weake
Saccharomyces Cerevisiae Cdc7 Homology In Drosophila Melanogaster, Marcus R. Hosler, Robert E. Stephenson, Vikki M. Weake
The Summer Undergraduate Research Fellowship (SURF) Symposium
Saccharomyces cerevisiae Dbf4(Dumbbell former 4) and Cdc7(Cell Division Cycle 7) form a complex that phosphorylates Mcm2 (Minichromosome maintenance 2) to initiate DNA replication. Cdc7 is a target for cancer research because there is a Cdc7 ortholog in humans that is necessary for DNA replication and cell survival. Our goal is to characterise a putative Cdc7 homolog in Drosophila melanogaster (dCdc7). We have previously shown that expression of the known Drosophila Dbf4 ortholog, Chiffon, and dCdc7 can rescue yeast cells deficient in active Cdc7. Our hypothesis is that the dCdc7 is activated by Chiffon to phosphorylate MCM2. To test this hypothesis, …
Development Of A Metabolomic Method To Define The Phenylalanome In Arabidopsis Thaliana, Cole G. Wunderlich, Clint Chapple, Xu Li
Development Of A Metabolomic Method To Define The Phenylalanome In Arabidopsis Thaliana, Cole G. Wunderlich, Clint Chapple, Xu Li
The Summer Undergraduate Research Fellowship (SURF) Symposium
In the study of metabolomics, one of the greatest challenges can be accurately identifying compounds detected in biological extracts, especially when standards are not readily available. Current metabolomic methods are also limited in that they provide little to no information about a compound’s metabolic origin. In this study, we sought to address these issues by developing a novel metabolomic method that employs stable isotope feeding, LC-MS, Xcms, and an analytical software algorithm to study the ‘phenylalanome’ of Arabidopsis thaliana. Using this approach we were able to develop a method that, based on current results, is capable of detecting over …
The Effects Of Exogenous Extracellular Matrix And Substrate Stiffness On Mouse Tendon Cells In Vitro, Caleb J. Mcdaniel, Sarah Calve
The Effects Of Exogenous Extracellular Matrix And Substrate Stiffness On Mouse Tendon Cells In Vitro, Caleb J. Mcdaniel, Sarah Calve
The Summer Undergraduate Research Fellowship (SURF) Symposium
To improve the treatment of musculoskeletal injuries, a better understanding of the transitional environment in which progenitor cells form mature musculoskeletal constructs is necessary. This need arises because injury repair requires restructuring of tissue, similar to the initial tissue construction that occurs during embryonic development by progenitor cells. Differences in both the biochemical and mechanical environments between a transitional and a differentiated state are known to take place, but how these differences affect cell behavior had not yet been characterized in mammalian tendon cells. In order to investigate this, we have determined the effects of exogenous extracellular matrix and the …
Novobiocin As An Allosteric Modulator Of Ste2p, Jeffrey K. Rymer, Melinda Hauser, Jeffrey M. Becker
Novobiocin As An Allosteric Modulator Of Ste2p, Jeffrey K. Rymer, Melinda Hauser, Jeffrey M. Becker
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
G protein-coupled receptors (GPCRs) are the target of 30-50% of all prescribed drugs for human medicine and are therefore the subject of intense study by the scientific community. It has been recognized recently that compounds called allosteric modulators can regulate GPCR activity by binding a GPCR at sites not occupied by the normal receptor-activating molecule. Such allosteric compounds are desirable drug candidates as they may produce fewer toxic side-effects than standard drugs that target GPCRs. The purpose of this study was to determine the interaction of different allosteric modulators with Ste2p, a model GPCR expressed in the yeast Saccharomyces cerevisiae. …
Investigation Of Ionizable Groups That Participate In ᴅ-Arginine Dehydrogenase Catalysis And Binding, Jacob A. Ball
Investigation Of Ionizable Groups That Participate In ᴅ-Arginine Dehydrogenase Catalysis And Binding, Jacob A. Ball
Georgia State Undergraduate Research Conference
No abstract provided.
Probing Manganese (Iii) And (Iv) Porphyrin Complexes With Different Coordination Numbers And Oxidation States By Uv-Vis And 1h-Nmr Spectroscopy, Laren Cyr
Georgia State Undergraduate Research Conference
No abstract provided.
Development Of Novel Inhibitors Targeting Epigenetic Enzymes, Johnny Truong, Leilei Yan Dr., Brandon Canup, Kun Qian, George Y. Zheng Dr.
Development Of Novel Inhibitors Targeting Epigenetic Enzymes, Johnny Truong, Leilei Yan Dr., Brandon Canup, Kun Qian, George Y. Zheng Dr.
Georgia State Undergraduate Research Conference
No abstract provided.
Axial Ligands Of The Heme Uptake Protein Hmut From Corynebacterium Diphtheriae, Brandford K. Adobaw, Kimberley Bartlett, Elizabeth Bennett, Dabney Dixon
Axial Ligands Of The Heme Uptake Protein Hmut From Corynebacterium Diphtheriae, Brandford K. Adobaw, Kimberley Bartlett, Elizabeth Bennett, Dabney Dixon
Georgia State Undergraduate Research Conference
No abstract provided.
Ph And Solvent Viscosity Effects Of ᴅ-Arginine Dehydrogenase With Different ᴅ-Amino Acid Substrates, Quan Bui
Ph And Solvent Viscosity Effects Of ᴅ-Arginine Dehydrogenase With Different ᴅ-Amino Acid Substrates, Quan Bui
Georgia State Undergraduate Research Conference
No abstract provided.