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Full-Text Articles in Biochemistry
An Active Site Loop Mutant Of A Zinc Metallo-Deubiquitinase Suggests The Importance Of Loop Dynamics To Catalysis, Amy N. Bueno
An Active Site Loop Mutant Of A Zinc Metallo-Deubiquitinase Suggests The Importance Of Loop Dynamics To Catalysis, Amy N. Bueno
Open Access Theses
AMSH is a conserved zinc metalloprotease that functions with endosomal sorting complexes required for transport (ESCRT) machinery in order to down regulate and degrade cell-surface receptors. It has been shown to have high specificity toward Lys63-linked polyubiquitin chains, a signal used for receptor down regulation by ESCRT machinery. It has previously been found that Sst2, an AMSH orthologue from fission yeast, contains a flexible "loop" near the proximal ubiquitin binding site, composed of residues L402 and F403. The different mobility of the side chains of these residues contribute to the opening and closing conformation of the catalytic cleft which allow …
Support Needs Of Young Ovarian Cancer Survivors: A Pilot Study, Aurelie Chuong
Support Needs Of Young Ovarian Cancer Survivors: A Pilot Study, Aurelie Chuong
Open Access Theses
Purpose. Young ovarian cancer survivor (18 years old or older but diagnosed before the age of 34 years old) support needs (i.e., physical and daily living, psychological, sexual, patient care and support, health system and information) were examined to guide the design and implementation of future young adult and adolescent cancer support groups and interventions. Method. This cross-sectional pilot study included 11 young ovarian cancer survivors. The Supportive Care Needs Survey Short Form 34 (SCNS-SF34) was used and open-ended questions were added. Results. The calculated standardized scores for the SCNS-SF34 survey results showed that sexuality needs were ranked highest (41.7 …