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Full-Text Articles in Biochemistry
Investigating The Link Between Mrna Binding To Hts1/Tys1 Trna Synthetases And Charcot Marie Tooth Neuropathy, Hallie G. Ryan, Sarah Mitchell
Investigating The Link Between Mrna Binding To Hts1/Tys1 Trna Synthetases And Charcot Marie Tooth Neuropathy, Hallie G. Ryan, Sarah Mitchell
Honors Thesis
RNA binding proteins (RBPs) are critical in regulating gene expression and many cellular functions. Recent proteome-wide studies have revealed hundreds of novel RBPs showing new modes of binding. A subset of RBPs known as aminoacyl tRNA synthetases (aaRS) catalyze the covalent ligation of an amino acid with its corresponding tRNA in the synthesis of aminoacyl-tRNAs. A recent study found a significant number of novel mRNA-binding proteins to be cytosolic aaRS. The novel functions of RBPs and aaRS are important to consider for their potential relationships to human disease pathology. Dominant intermediate Charcot Marie Tooth type C, also known as DI-CMTC, …
Optimization Of Methods For Cross-Species Infection Of Cell Cultures With Wolbachia, Sarah J. Lane
Optimization Of Methods For Cross-Species Infection Of Cell Cultures With Wolbachia, Sarah J. Lane
Honors Thesis
The common intracellular endosymbiont genus of bacteria called Wolbachia is of interest due to the promise it shows for playing a role in disease control. Wolbachia have a number of widely variable effects on its many species of host insects. In combination with these roles, Wolbachia largely affects reproduction and development of its host species. It can lead to feminization and cytoplasmic incompatibility (Werren et al. 2008). Furthermore, this species is vertically transmitted which means that it passes from mother to offspring (Caragata et al., 2016). In combination with its effects on reproduction, which can allow Wolbachia to propagate through …