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Full-Text Articles in Biochemistry
De Novo Design Of Artificial Cu Peptide For Substrate Oxidation And An Electrochemical Approach To Determine Reorganization Energy, Morgan Murphy
De Novo Design Of Artificial Cu Peptide For Substrate Oxidation And An Electrochemical Approach To Determine Reorganization Energy, Morgan Murphy
Honors Theses
Copper enzymes are found in nature. Their mechanisms and properties are unknown, as spectroscopy is limited. By creating artificially designed copper peptides through de novo design, the behavior, characteristics, and spectroscopy of copper enzymes can be studied to enhance understanding of the mechanisms involved with enzyme catalysis. Design, synthesis, purification, and characterization are completed to create a quality peptide mutant that can be studied to learn about natural enzymes. This plays an important role in pharmaceutical research, renewable energy sourcing, and studies of biological processes in the body. In this study, 3SCC de novo peptide is mutated at different positions, …
Retro-Structural Analysis Of The Four Helix Bundle Motif In Binuclear Proteins, Walker Pedigo, Maggie Smith
Retro-Structural Analysis Of The Four Helix Bundle Motif In Binuclear Proteins, Walker Pedigo, Maggie Smith
Honors Theses
Protein structure is directly related to protein function. There are four levels of protein structure: primary, secondary, tertiary, and quaternary. The interactions amongst the structural components of a protein give rise to its unique characteristics. The four helix bundle motif is a common structural trait in a variety of binuclear proteins. In this study, PyMOL, a molecular visualization system, was used to analyze binuclear proteins that possess a four helix bundle. Images of proteins containing dicopper, diiron, and dimanganese sites were captured. The images were compiled into figures for each individual protein. After creating the figures, each protein was further …