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Full-Text Articles in Biochemistry
Using Nmr Chemical Shift Perturbations To Map Interactions Between Acyl-Acyl Carrier Proteins And Acyl Homoserine Lactone Synthases, Madison N. Rizzo
Using Nmr Chemical Shift Perturbations To Map Interactions Between Acyl-Acyl Carrier Proteins And Acyl Homoserine Lactone Synthases, Madison N. Rizzo
Boise State University Theses and Dissertations
A pandemic of antibiotic resistance is underway and affecting multiple industries, including veterinary, agricultural, and healthcare. High bacterial population density is a major form of defense for bacterial cells against drugs, contributes to antibiotic resistance, and is one of the requirements for the formation of biofilms. Quorum sensing is a form of cell-to-cell communication that both gram-negative and gram-positive bacteria use to account for density behavior. When the population density of bacteria reaches a certain level (a “quorum”), there is an observed coordinated shift in gene expression that leads to optimized growth or virulence. Acyl carrier proteins (ACP) and the …
Acyl-Homoserine Lactone Based Modulators For Rhli, A Quorum Sensing Signal Synthase In Pseudomonas Aeruginosa, Daniel D. Shin
Acyl-Homoserine Lactone Based Modulators For Rhli, A Quorum Sensing Signal Synthase In Pseudomonas Aeruginosa, Daniel D. Shin
Boise State University Theses and Dissertations
Gram-negative bacteria use N-acyl-homoserine lactone (AHL) autoinducer based signal system, known as quorum sensing (QS), to modulate the gene expression for such traits as biofilm formation, toxin production, and antibiotic resistance. Therefore, there is great potential in pursuing quorum sensing inhibition (QSI) as a means of achieving antivirulence. Pseudomonas aeruginosa, an opportunistic pathogen commonly found in healthcare-related infections, use two LuxI/R type systems to regulate AHL-based quorum sensing: LasI/R and RhlI/R. LasI (initiator protein/signal synthase) and LasR (receptor) use 3-oxododecanoyl-L-homoserine lactone signal molecule while RhlI and RhlR use butanoyl-L-homoserine lactone autoinducer. Thus far, most of the studies have …