Biochemistry Commons^™

Examination Of Klebsiella Pneumoniae 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase And 5-Methylthioribose Kinase, Jason Alan Stonick

Boise State University Theses and Dissertations

Klebsiella pneumoniae is an opportunistic bacterial pathogen that is emerging as a major global threat as an infectious agent. This organism, along with many other pathogens, possesses a broad suite of antibiotic resistances that can make treatment exceedingly difficult. As such, the impetus for creating novel antibiotics is at an all-time high despite the fact that pharmaceutical investment into drug development is at an all-time low. S-adenosylmethionine (SAM) is a universally utilized metabolite involved in a wide array of biosynthetic processes, and whose products are catabolized by a different set of enzymes in mammals than used by many bacteria, protozoa, …