Biochemistry Commons^™

Using Nmr Chemical Shift Perturbations To Map Interactions Between Acyl-Acyl Carrier Proteins And Acyl Homoserine Lactone Synthases, Madison N. Rizzo

Boise State University Theses and Dissertations

A pandemic of antibiotic resistance is underway and affecting multiple industries, including veterinary, agricultural, and healthcare. High bacterial population density is a major form of defense for bacterial cells against drugs, contributes to antibiotic resistance, and is one of the requirements for the formation of biofilms. Quorum sensing is a form of cell-to-cell communication that both gram-negative and gram-positive bacteria use to account for density behavior. When the population density of bacteria reaches a certain level (a “quorum”), there is an observed coordinated shift in gene expression that leads to optimized growth or virulence. Acyl carrier proteins (ACP) and the …