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Full-Text Articles in Biochemistry
Structure-Function Relationship Of The Ligand-Binding Domain Of The Fibroblast Growth Factor Receptor, Ryan Thurman
Structure-Function Relationship Of The Ligand-Binding Domain Of The Fibroblast Growth Factor Receptor, Ryan Thurman
Graduate Theses and Dissertations
The interactions between FGF and fibroblast growth factor receptors are responsible for the regulation of key cellular processes. FGF is important in both germ cell and embryonic developments. FGF continues to play important roles during adulthood by regulating embryogenesis, cell differentiation, and wound healing (1-7). The regulations of these cellular events are initiated through FGF binding to the fibroblast growth factor receptors. The complex formed by FGF and the receptor involves a key interaction with heparin. Through interactions with heparin, the FGF, FGFR and Heparin form a 2:2:2 complex (8). This complex formation results in autophosphorylation in the tyrosine kinase …