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Investigations Of The Ppi-Dependent Acetate Kinase From The Parasite Entamoeba Histolytica, Matthew Fowler
Investigations Of The Ppi-Dependent Acetate Kinase From The Parasite Entamoeba Histolytica, Matthew Fowler
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Acetate, a short-chain fatty acid that plays a key role in all domains of life, can be utilized as a carbon source or excreted as a product of metabolism. Acetate kinase (ACK), a member of the acetate and sugar kinase-Hsp70-actin (ASKHA) enzyme superfamily, is responsible for the reversible phosphorylation of acetate to acetyl phosphate utilizing ATP as the phosphoryl donor. Acetate kinases are ubiquitous in the Bacteria, found in one genus of Archaea, and are also present in microbes of the Eukarya. A partially purified ACK which can utilize pyrophosphate (PPi) as the phosphoryl donor in the acetyl …