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Articles 1 - 6 of 6
Full-Text Articles in Biochemistry
The Potential For Dickeya Dianthicola To Be Vectored By Two Common Insect Pests Of Potatoes, Jonas K. Insinga
The Potential For Dickeya Dianthicola To Be Vectored By Two Common Insect Pests Of Potatoes, Jonas K. Insinga
Electronic Theses and Dissertations
Dickeya dianthicola (Samson) causing blackleg and soft rot was first detected in potatoes grown in Maine in 2014. Previous work has suggested that insects, particularly aphids, may be able to vector bacteria in this genus between plants, but no conclusive work has been done to confirm this theory. In order to determine whether insect-mediated transmission is likely to occur in potato fields, two model potato pests common in Maine were used: the Colorado potato beetle (Leptinotarsa decimlineata Say) and the green peach aphids (Myzus persicae Sulzer). Olfactometry and recruitment experiments evaluated if either insect discriminates between infected and …
Cpsa Protein-Protein Interactions In Group B Streptococcus, Ben Tero
Cpsa Protein-Protein Interactions In Group B Streptococcus, Ben Tero
Honors College
Group B Streptococcal (GBS) infections pose a great threat to mortality in neonates. Neonates are often exposed to GBS both before, during, and after delivery, which can cause a range of health problems including meningitis, sepsis, or stillbirth. One of the major virulence factors that contributes to the infectivity of the pathogen is the bacterial capsule. The capsule is a polysaccharide matrix surrounding the cell which helps in the evasion of host defenses, and penetration into normally sterile sites like the bloodstream. The highly conserved GBS protein CpsA has been shown to regulate expression of the capsule. The objective of …
Dynamic Regulation Of G-Protein Signaling, William C. Simke
Dynamic Regulation Of G-Protein Signaling, William C. Simke
Electronic Theses and Dissertations
G protein-coupled receptors (GPCRs) are involved in numerous signaling processes ranging from neuronal growth to immune cells tracking invaders. GPCR signaling plays a role in many human diseases and thus GPCRs are important drug targets. Yeast respond to mating pheromone using a GPCR signaling system homologous to those used in humans to polarize their cytoskeleton toward the pheromone source. This is accomplished by initializing a MAPK signaling cascade to arrest the cells in mitosis and upregulate expression of chemotropic proteins. Pathway desensitization is accomplished by the Regulator of G-protein Signaling (RGS). RGS abrogates signaling by binding to the active GPCR, …
Cellular And Molecular Mechanisms Of Mapk Signaling During Jc Polyomavirus Infection, Jeanne Dushane
Cellular And Molecular Mechanisms Of Mapk Signaling During Jc Polyomavirus Infection, Jeanne Dushane
Electronic Theses and Dissertations
As obligate intracellular parasites, viruses must infect a host-cell and requisition cellular machinery for viral replication. JC polyomavirus (JCPyV) is a ubiquitous human pathogen that can cause a lytic infection in glial cells of the central nervous system in immunocompromised individuals. In order to initiate infection however, the virus must alter prototypical cellular processes that promote cellular homeostasis. The main driver of these processes are signaling pathways, the means by which the cell interacts and responds to the extracellular environment. Many signaling cascades are responsible for promoting growth, responding to pathogens, initiating differentiation, or inducing cell death. Through the works …
Genomic And Proteomic Effects Of Red Raspberry (Rubus Idaeus) Consumption On The Perivascular Adipose Tissue Of The Obese Zucker Rat, A Model Of Human Metabolic Syndrome, Jasmine Waite
Honors College
The Metabolic Syndrome (MetS) affects 35% of U.S. adults and is an indicator of early death. While pharmacological treatments have been developed for the majority of MetS risk factors, obesity-induced inflammation remains to be addressed. Dysfunctional adipose tissue is a source of inflammation, and perivascular adipose tissue (PVAT) is critical in its pathogenesis. This study investigates the effects of red raspberry (rubus idaeus) diet-enrichment on inflammation of PVAT. The obese Zucker rat (OZR) model of MetS and the lean Zucker rat (LZR) control (C) model were used. Rats received an eight-week control or whole red raspberry-enriched (WRR) diet …
Determining The Key Residues For Capsule Production In The Gbs Cpsa Protein, Anna Struba
Determining The Key Residues For Capsule Production In The Gbs Cpsa Protein, Anna Struba
Honors College
Streptococcus agalactiae (GBS) is a common bacterium found commensally in the vaginal mucosa of healthy adults. GBS also causes severe infection in neonates, often leading to meningitis, which can cause lifelong health consequences including impaired hearing and seizures. Infection of newborns mainly arises from a colonized mother, either before birth through ascending infection or during labor. Ascending infection, where the bacteria travel to the fetus from the vaginal mucosa, is especially concerning as it can lead to loss of pregnancy or premature birth. The most common method of neonatal GBS disease prevention is antibiotic prophylaxis during delivery, though this method …