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Full-Text Articles in Biochemistry
Cortisol Receptor Sensitivity As A Risk Factor For Depression, Michela Michielli
Cortisol Receptor Sensitivity As A Risk Factor For Depression, Michela Michielli
Honors Theses
In 2020, the World Health Organization reported over 264 million people across the world were suffering from depression. Studies have demonstrated that one source of depression is a hormonal imbalance involved in the stress response. Cortisol is a stress hormone regulated by the Hypothalamic-Anterior-Pituitary (HPA) Axis. Its effects on the stress response and other metabolic activities in the body are exerted through the glucocorticoid and mineralocorticoid receptors (GR and MR respectively).
Our research has examined mutations known as single-nucleotide-polymorphisms (SNPs) relating to cortisol-receptor sensitivity and the behavior of cortisol in the body to investigate the link between cortisol activity and …
Ck2 Negatively Regulates 5-Ht4 Receptor Signaling In The Prefrontal Cortex And Mediates Depression-Like Behaviors, Julia Castello Saval
Ck2 Negatively Regulates 5-Ht4 Receptor Signaling In The Prefrontal Cortex And Mediates Depression-Like Behaviors, Julia Castello Saval
Dissertations, Theses, and Capstone Projects
The serotonergic system has been the major candidate in the pathophysiology of mood related disorders such as anxiety and major depressive disorder (MDD). Unfortunately, current antidepressant drugs are ineffective in 50% of the population and require chronic administration for a period of 3-6 weeks before the onset of therapeutic response. 5-HT4 receptor (5-HT4R) agonists have emerged as potential candidates for fast antidepressant action, since an antidepressant response can be achieved after 3 days of pharmacological administration in rodents.
This dissertation aims to investigate the role of casein kinase 2 (CK2) as a regulator of 5-HT4R expression …
Quantifying The Spectrum Of Depression, Octavious Bishop
Quantifying The Spectrum Of Depression, Octavious Bishop
Walden Dissertations and Doctoral Studies
Walden University
College of Social and Behavioral Sciences
This is to certify that the doctoral dissertation by
Octavious Bishop
has been found to be complete and satisfactory in all respects,
and that any and all revisions required by
the review committee have been made.
Review Committee
Dr. Thomas Edman, Committee Chairperson, Psychology Faculty
Dr. Ricardo Thomas, Committee Member, Psychology Faculty
Dr. Joanna Bissell-Havran, University Reviewer, Psychology Faculty
Chief Academic Officer
Eric Riedel, Ph.D.
Quantifying the Spectrum of Depression
by
Octavious Bishop
MA, University of Texas at Austin, 2008
BS, University of Texas at Austin, 2001
Dissertation Submitted in Partial Fulfillment …