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- Neurodegeneration (2)
- Alzheimer's (1)
- Alzheimer's Disease (1)
- Amyloid-beta (1)
- Antibody (1)
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- As those identified in primary tauopathies (e.g. P301L and G389R) (1)
- Biochemistry (1)
- Both enhanced vesicular release of tau in the extracellular space (1)
- CaMKII (1)
- DNA (1)
- Due to a process called phase separation. My Thesis tested the hypothesis that tau mutations (1)
- Expression (1)
- Hippocampus (1)
- In both HEK293T and SHSY-5Y cells compared to wild type. However (1)
- Into either HEK293T (1)
- It has recently been well accepted that tau is also an intrinsically disordered protein that tends to form membraneless organelles called coacervates (1)
- MAbSL (1)
- Mass spectrometry (1)
- Memory (1)
- Might impair the phase separation properties of the protein and impact its pathological role in cells. I first tested the effect of single amino acid substitutions in vitro (1)
- Neuroscience (1)
- One third is characterized by the presence of genetic mutations leading to the synthesis of tau proteins with single amino acid substitutions at specific locations and affecting protein function. While most of the initial studies have emphasize the functional role of tau as modulator of the axonal cytoskeleton (1)
- Or in SHSY-5Y neuroblastoma cells (1)
- Phase Separation (1)
- Plasmid (1)
- Protein (1)
- Protofibrils (1)
- Purification (1)
- SecretionTau is a protein expressed exclusively in glia and neurons in the central nervous system and implicated in several neurogenerative diseases called “tauopathies”. Among all the tauopathies (1)
- Tau (1)
Articles 1 - 3 of 3
Full-Text Articles in Biochemistry
Characterization Of Pathological Tau Mutants, Charles J. Mcdonald
Characterization Of Pathological Tau Mutants, Charles J. Mcdonald
Dissertations, Theses, and Capstone Projects
Tau is a protein expressed exclusively in glia and neurons in the central nervous system and implicated in several neurogenerative diseases called “tauopathies”. Among all the tauopathies, one third is characterized by the presence of genetic mutations leading to the synthesis of tau proteins with single amino acid substitutions at specific locations and affecting protein function. While most of the initial studies have emphasize the functional role of tau as modulator of the axonal cytoskeleton, it has recently been well accepted that tau is also an intrinsically disordered protein that tends to form membraneless organelles called coacervates, due to a …
Probing Amyloid-Beta Protein Structure And Dynamics With A Selective Antibody, Shikha Grover
Probing Amyloid-Beta Protein Structure And Dynamics With A Selective Antibody, Shikha Grover
Dissertations
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. The AD brain is characterized by significant neuronal loss and accumulation of insoluble fibrillar amyloid-β protein (Aβ) plaques and tau protein neurofibrillary tangles in the brain. However, over the last decade, many studies have shown that the neurodegenerative effect of Aβ may in fact be caused by various soluble oligomeric forms as opposed to the insoluble fibrils. Furthermore, the data suggest that a pre-fibrillar aggregated form, termed protofibrils, mediates direct neurotoxicity, and triggers a robust neuroinflammatory response.
Antibodies targeting the various conformation of Aβ are important therapeutic agents to prevent the progression …
Characterizing The Roles Of The Variable Linker And Hub Domains In Camkii Activation, Noelle Dziedzic
Characterizing The Roles Of The Variable Linker And Hub Domains In Camkii Activation, Noelle Dziedzic
Doctoral Dissertations
Learning and memory formation at the cellular level involves decoding complex electrochemical signals between nerve cells, or neurons. Understanding these processes at the molecular level requires a comprehensive study of calcium-sensitive proteins that serve as signal mediators within cells. More specifically, the protein calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of downstream cellular signaling events in the brain, playing an important role in long term memory formation. CaMKII is encoded in humans on four different genes: alpha, beta, gamma and delta. For added complexity, each of these gene products can be alternatively spliced and translated into multiple protein …