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Full-Text Articles in Biochemistry
The Role Of Oxidative Stress In The Mechanisms Of Ammonia-Induced Brain Swelling And Tolerance In The Goldfish (Carassius Auratus), David F. Jones Lisser Mr.
The Role Of Oxidative Stress In The Mechanisms Of Ammonia-Induced Brain Swelling And Tolerance In The Goldfish (Carassius Auratus), David F. Jones Lisser Mr.
Theses and Dissertations (Comprehensive)
Toxic build-ups of ammonia can cause potentially fatal brain swelling in mammals, but such swelling is reversible in the anoxia- and ammonia-tolerant goldfish (Carassius auratus). The mechanisms of ammonia-induced brain swelling and tolerance remain elusive, but several studies have suggested a role for reactive oxygen species (ROS), which may damage proteins and lipids in the plasma membrane of astrocytes in the brain. As a result, osmotic gradients across cell membranes may be altered leading to water uptake by astrocytes and swelling. While a role for ROS has been proposed in mammals, no studies have addressed this question in …
Characterization Of The Trans-Plasma Membrane Electron Transport System In The Myelin Membrane, Afshan Sohail
Characterization Of The Trans-Plasma Membrane Electron Transport System In The Myelin Membrane, Afshan Sohail
Theses and Dissertations (Comprehensive)
Myelination is the key feature of evolution in the nervous system of vertebrates. Myelin is the protrusion of glial cells. More specifically, "oligodendrocytes" in the central nervous system (CNS), and "Schwann" cells in the peripheral nervous system (PNS) form myelin membranes. Myelin remarkably, enhances the propagation of nerve impulses. However, myelin restricts the access of extracellular metabolites to the axons. A pathology called "demyelination" is associated with myelin. The myelin sheath is not only an insulator, but it is itself metabolically active. In this study it is hypothesized that the ratio of NAD(P)+/NAD(P)H and the glycolytic pathway of …
Characterization Of The Transporter Protein Sodium-Potassium Adenosine Triphosphatase In The Myelin Membrane, Dara E C Schaefer
Characterization Of The Transporter Protein Sodium-Potassium Adenosine Triphosphatase In The Myelin Membrane, Dara E C Schaefer
Theses and Dissertations (Comprehensive)
Sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) is an integral membrane protein with known involvement in the maintenance of resting membrane potentials, nutrient uptake, cellular signal transduction, and cell-cell adhesion. The functional enzyme contains a catalytic alpha subunit and a glycosylated beta subunit, of which three isoforms of each are known to exist in the central nervous system (CNS). Altered expression and/or activity of Na+/K+-ATPase subunit isoforms has been previously implicated in the pathophysiology of several neurological disorders. This study characterized Na+/K+-ATPase expression and distribution in the myelin membrane, identified its …