Open Access. Powered by Scholars. Published by Universities.®
- Publication
Articles 1 - 4 of 4
Full-Text Articles in Biochemistry
The Impact Of A Non-Ionic Adjuvant To The Persistence Of Pesticides On Produce Surfaces, Daniel Barnes
The Impact Of A Non-Ionic Adjuvant To The Persistence Of Pesticides On Produce Surfaces, Daniel Barnes
Masters Theses
Adjuvants can enhance the performance of the pesticide active ingredients in many ways including decreasing surface tension and reducing evaporation. Understanding how adjuvants effect pesticide behavior (e.g., surface persistence) is crucial for developing effective pesticide formulations, as well as facilitating the development of effective approaches to reduce pesticide residues from the surface of fresh produce post-harvest. The objective of this study is to investigate the effect of a non-ionic surfactant, Surf-Ac 910, on the persistence of two model pesticides, thiabendazole and phosmet on apple surfaces. The result shows that the addition of Surf-Ac 910 increased both the maximum wetted area …
Hybridized Polymeric Nano-Assemblies: Key Insights Into Addressing Mdr Infections, Ryan Landis
Hybridized Polymeric Nano-Assemblies: Key Insights Into Addressing Mdr Infections, Ryan Landis
Doctoral Dissertations
Multidrug-resistant (MDR) bacteria contribute to more than 700,000 annual deaths world-wide. Millions more suffer from limb amputations or face high healthcare treatment costs where prolonged and costly therapeutic regimens are used to counter MDR infections. While there is an international push to develop novel and more powerful antimicrobials to address the impending threat, one particularly interesting approach that has re-emerged are essential oils, phytochemical extracts derived from plant sources. While their antimicrobial activity demonstrates a promising avenue, their stability in aqueous media, limits their practical use in or on mammals. Inspired by the versatility of polymer nanotechnology and the sustainability …
The Heat Shock Cognate 70 Protein (Hsc70) Is A Novel Target For Nobiletin In Colon Cancer Cells, Zili Gao
The Heat Shock Cognate 70 Protein (Hsc70) Is A Novel Target For Nobiletin In Colon Cancer Cells, Zili Gao
Doctoral Dissertations
Nobiletin (NBT) is a unique flavonoid mainly found in citrus fruits, and has been reported to inhibit colon carcinogenesis in multiple rodent models. However, the direct molecular targets of NBT are unknown. Heat shock cognate 70 protein (HSC70) contributes to cancer cell survival and resistance to chemotherapies, thereby the inhibition of HSC70 is a promising strategy in cancer chemoprevention. Using affinity chromatography, proteomics analysis and computer modeling, we demonstrated that NBT bound to HSC70 at its ATP-binding site and specifically inhibited its ATPase activity. The association between HSC70 and HSP90 is critical for the stability of their client proteins, which …
Chemical Stability Of Curcumin: Structure And Activity Relationship (Sar) Study, Zheyuan Du
Chemical Stability Of Curcumin: Structure And Activity Relationship (Sar) Study, Zheyuan Du
Masters Theses
Over the past decades, numerous studies have shown that curcumin has potent biological activities. As a potential chemopreventing agent, curcumin was demonstrated to exert anti-cancer effects in both in vitro and in vivo studies. However, low bioavailability of curcumin limited human clinical trials and its application to be formulated as therapeutics. In this thesis, we will summarize the anti-cancer effects of curcumin in animal studies and clinical trials. In addition, an SAR study will be introduced to elucidate the mechanism of curcumin degradation at physiological pH. We synthesized various curcumin analogues and compared their stability in phosphate buffer using HPLC …