Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Biochemistry
Nuclear Receptor Coactivator 3 In Endoplasmic Reticulum Stress And Stress Granule Dynamics In Pancreatic Cancer, Andrew Kisling
Nuclear Receptor Coactivator 3 In Endoplasmic Reticulum Stress And Stress Granule Dynamics In Pancreatic Cancer, Andrew Kisling
Theses & Dissertations
Pancreatic cancer is predicted to be the second-leading cause of cancer-related deaths within the next decade. Nuclear receptor coactivator 3 (NCOA3/SRC3/AIB1) regulates an array of metabolic and signaling pathways and has been established by our group and others as a critical regulator pancreatic cancer progression and metastasis. A recent study demonstrated NCOA3 regulation by the IRE1α-XBP1 axis of the unfolded protein response (UPR), suggesting a link between NCOA3 and cellular stress management. Furthermore, NCOA3 has been shown to directly bind to a scaffolding protein of stress granules (SGs). Since SG assembly is regulated by the UPR, we hypothesized that NCOA3 …
Developing Targeted Therapy Against Pancreatic Cancer, Garima Kaushik
Developing Targeted Therapy Against Pancreatic Cancer, Garima Kaushik
Theses & Dissertations
Not available.
Effect Of Oil Palm Phenolics (Opp) On Pancreatic Cancer Cell Lines, Inaam Abdul Karim
Effect Of Oil Palm Phenolics (Opp) On Pancreatic Cancer Cell Lines, Inaam Abdul Karim
Wayne State University Theses
Pancreatic cancer (paca) is currently the fifth causes of cancer-related deaths in the United States. It’s an aggressive form of cancer with very low survival rates because of delayed diagnosis and limited treatment options. Gemcitabine is the chemotherapy drug that provides minimal benefits along with many side effects. The aim of this study was to examine the in vitro effects of oil palm phenolics (OPP) fraction-5, the water-soluble component of palm oil, in human pancreatic cancer cell models. Two pancreatic cancer cell lines (Panc-1 and BxPC-3) were categorized into control and treatment groups. The control group received cell culture media …
The Role Of Semaphorin 5a In Pancreatic Cancer Progression And Metastasis, Sugandha Saxena Dr.
The Role Of Semaphorin 5a In Pancreatic Cancer Progression And Metastasis, Sugandha Saxena Dr.
Theses & Dissertations
Pancreatic cancer (PC) is an aggressive disease with an overall 5-year survival rate of less than 7%, statistics that have not changed in almost five decades. Metastasis is one of the leading causes of mortality in PC. Accumulating evidence suggests that axon guidance molecules, such as semaphorins, are involved in cancer progression, invasion, and metastasis. Recent genomic characterization of pancreatic ductal adenocarcinoma revealed aberration in axon guidance pathway genes as well. Previous reports from our laboratory have identified one such molecule Semaphorin5A (SEMA5A) as a putative cell adhesion molecule which is involved in organ-specific homing during PC metastasis. My dissertation …