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Regulation Of C-Raf Stability By The Ranbpm/Ctlh Complex, Christina J. Mctavish
Regulation Of C-Raf Stability By The Ranbpm/Ctlh Complex, Christina J. Mctavish
Electronic Thesis and Dissertation Repository
RanBPM is an evolutionarily conserved multi-domain protein that has been implicated in the regulation of several cellular process, including protein stability, cell migration, gene transcription, and apoptosis. RanBPM is identified as a key member of the CTLH complex, an orthologous complex to a yeast E3 ubiquitin ligase complex, the exact function of which remains unknown. Previously, our laboratory identified RanBPM as an inhibitor of the ERK1/2 pathway through the modulation of C-RAF protein levels. This study shows that RanBPM-mediated degradation of C-RAF occurs through the proteasome and the entire CRA domain of RanBPM is necessary for direct interaction with C-RAF …