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- Electroporation (2)
- Atomic structures (1)
- Beta strands (1)
- Cryo electron microscopy (1)
- Electron microscopy maps (1)
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- Electropermeabilization (1)
- Fitting (1)
- Gene electrotransfer (1)
- Identification (1)
- Molecular dynamics (1)
- Picosecond (1)
- Protein structure (1)
- Pulsed electric fields (1)
- Reconstructions (1)
- Registration (1)
- Resolution density maps (1)
- Secondary (1)
- Secondary structure (1)
- Situs (1)
- Structural informatics approach (1)
- Structure elements (1)
- Terahertz (1)
- Validation (1)
- Water bridge (1)
Articles 1 - 3 of 3
Full-Text Articles in Biochemistry
Picosecond To Terahertz Perturbation Of Interfacial Water And Electropermeabilization Of Biological Membranes, P. Thomas Vernier, Zachary A. Levine, Ming-Chak Ho, Shu Xiao, Iurii Semenov, Andrei G. Pakhomov
Picosecond To Terahertz Perturbation Of Interfacial Water And Electropermeabilization Of Biological Membranes, P. Thomas Vernier, Zachary A. Levine, Ming-Chak Ho, Shu Xiao, Iurii Semenov, Andrei G. Pakhomov
Bioelectrics Publications
Non-thermal probing and stimulation with subnanosecond electric pulses and terahertz electromagnetic radiation may lead to new, minimally invasive diagnostic and therapeutic procedures and to methods for remote monitoring and analysis of biological systems, including plants, animals, and humans. To effectively engineer these still-emerging tools, we need an understanding of the biophysical mechanisms underlying the responses that have been reported to these novel stimuli. We show here that subnanosecond (≤500 ps) electric pulses induce action potentials in neurons and cause calcium transients in neuroblastoma-glioma hybrid cells, and we report complementary molecular dynamics simulations of phospholipid bilayers in electric fields in which …
Numerical Geometry Of Map And Model Assessment, Willy Wriggers, Jing He
Numerical Geometry Of Map And Model Assessment, Willy Wriggers, Jing He
Mechanical & Aerospace Engineering Faculty Publications
We are describing best practices and assessment strategies for the atomic interpretation of cryo-electron microscopy (cryo-EM) maps. Multiscale numerical geometry strategies in the Situs package and in secondary structure detection software are currently evolving due to the recent increases in cryo-EM resolution. Criteria that aim to predict the accuracy of fitted atomic models at low (worse than 8 angstrom) and medium (4-8 angstrom) resolutions remain challenging. However, a high level of confidence in atomic models can be achieved by combining such criteria. The observed errors are due to map-model discrepancies and due to the effect of imperfect global docking strategies. …
Introduction To Fifth Special Issue On Electroporation-Based Technologies And Treatments, Damijan Miklavčič, Lluis M. Mir, P. Thomas Vernier
Introduction To Fifth Special Issue On Electroporation-Based Technologies And Treatments, Damijan Miklavčič, Lluis M. Mir, P. Thomas Vernier
Bioelectrics Publications
This special issue of the Journal of Membrane Biology contains reports on recent developments in the field of electroporation by participants in the International Workshop and Postgraduate Course on Electroporation-Based Technologies and Treatments held in November 2014 in Ljubljana. This was the eighth session of what is now an annual event, first organized in 2003.