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Full-Text Articles in Biochemistry
Positive Regulation Of Pka On Human Gonadotropin-Releasing Hormone (Hgnrh) Gene Expression In Human Placental Jeg-3 Cells, Zhaoyang Wen
Positive Regulation Of Pka On Human Gonadotropin-Releasing Hormone (Hgnrh) Gene Expression In Human Placental Jeg-3 Cells, Zhaoyang Wen
Chemistry & Biochemistry Theses & Dissertations
Using the human placental choriocarcinoma JEG-3 cell line as an in vitro human placental model, we studied the mechanisms of the PKA positive regulation of the hGnRH gene expression in the human placenta. Studies in JEG3 cells showed that through the PKA catalytic subunit a, human GnRH upstream promoter activity was stimulated by PKA signaling pathway in a cAMP dependent mechanism. The sequence between —202 (Afl II) and —554 (BamH I) base pair in the human GnRH upstream promoter region appeared to be responsible for the PKA positive regulation of the gene expression. Furthermore, Western blot analysis demonstrated the involvement …
Protein Targeting And Translocation, Barry D. Bruce, D.A. Phoenix
Protein Targeting And Translocation, Barry D. Bruce, D.A. Phoenix
Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology
No abstract provided.
Protein Targeting And Translocation, Barry D. Bruce, D.A. Phoenix
Protein Targeting And Translocation, Barry D. Bruce, D.A. Phoenix
Barry D. Bruce
No abstract provided.