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- A process termed mechanotransduction. Through cell-ECM focal adhesions (1)
- Aid in the advancement of both tissue engineering and cancer treatment research. (1)
- And polyacrylamide gels containing fluorescent beads. The mobility of integrin on the different substrates was assessed using fluorescent recovery after photo-bleaching (FRAP) and analyzed along with cell traction force measurements. These studies serve to further the understanding of our knowledge of integrin and its role in mechanotransduction and migration. It will (1)
- AngiognesisThe formation of new vasculature is an essential process (1)
- But can also be utilized by cancerous cells. Angiogenesis requires the directed migration of the endothelial cells lining the nascent blood vessels. This process is largely mediated by integrin (1)
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- Candida albicans (1)
- Focal adhesion (1)
- Immunofluorescence microscopy (1)
- Integrin (1)
- Integrin mediates the signaling both into and out of the cell (1)
- Mechanotransduction (1)
- Pathogenic fungi (1)
- Polydimethylsiloxane (PDMS) micro pillars (1)
- Promoting growth of focal adhesions and subsequent cell spreading and migration. In order to study focal adhesion dynamics related to force (1)
- Therefore (1)
- Vertebrate immunity (1)
- We observed cells on three different substrates: polyacrylamide gels (1)
- Which plays a key role in the interplay between sensing a force in the extracellular matrix (ECM) and transducing this signal (1)
- Zebrafish (1)
Articles 1 - 2 of 2
Full-Text Articles in Biochemistry
Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter
Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter
Honors College
The innate immune system is highly conserved amongst all multicellular organisms. Yet a constant battle exists between host cells and pathogens due to the rapid evolution of immune system components. Functional genomics and in silico methods can be employed to elucidate the evolutionary patterns of vertebrate immunity to pathogenic fungi such as Candida albicans, an opportunistic fungal pathogen that can cause lethal candidiasis in the immunocompromised. Mammals such as humans and mice possess conserved C-type lectin receptors that recognize the C. albicans cell wall. However, these receptors have not been identified in fish. Here I describe how we identified potential …
A Novel Mechanism For Mechanosensing By Endothelial Cells, Jennifer Macdowell
A Novel Mechanism For Mechanosensing By Endothelial Cells, Jennifer Macdowell
Honors College
The formation of new vasculature is an essential process, but can also be utilized by cancerous cells. Angiogenesis requires the directed migration of the endothelial cells lining the nascent blood vessels. This process is largely mediated by integrin, which plays a key role in the interplay between sensing a force in the extracellular matrix (ECM) and transducing this signal, a process termed mechanotransduction. Through cell-ECM focal adhesions, integrin mediates the signaling both into and out of the cell, promoting growth of focal adhesions and subsequent cell spreading and migration. In order to study focal adhesion dynamics related to force, we …