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Full-Text Articles in Biochemistry
Experimental And Computational Analysis Of The Synucleins, Agatha Munyanyi
Experimental And Computational Analysis Of The Synucleins, Agatha Munyanyi
Theses and Dissertations in Biomedical Sciences
The synuclein proteins α, β and γ which are located in the brain, have been a subject of intense research. Of particular interest is α-synuclein, which is found in misfolded forms in Lewy bodies that are associated with Parkinson's disease. Despite the efforts of researchers across the world, the physiological structure and function of the synucleins remains elusive. In recent years, highly controversial reports by some investigators indicate that in its natural form, α-synuclein exists as a tetramer instead of as an intrinsically unstructured monomer. This dissertation presents results of the experimental and computational analysis of the synucleins. First, we …