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Biochemistry, Biophysics, and Structural Biology Commons™
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Articles 91 - 93 of 93
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Andrological Methods Of Predicting The Pregnancy Outcome Of An In Vitro Fertilization Program, Mahmood S. Morshedi
Andrological Methods Of Predicting The Pregnancy Outcome Of An In Vitro Fertilization Program, Mahmood S. Morshedi
Theses and Dissertations in Biomedical Sciences
Current advances in fertility treatment emphasize extracorporeal procedures, such as in vitro fertilization (IVF)/embryo transfer. IVF is now used to treat several types of infertility, including male factor and idiopathic infertility. However, IVF is time consuming, costly, unpredictable, and often yields a low pregnancy rate. Thus, it would be valuable to devise laboratory procedures for better prediction of IVF outcome.
The male infertility rate can be as high as 50%. Since sperm count and percent of motility alone do not appear to be strong predictors of IVF outcome especially when these parameters are not severely abnormal, a multivariable analysis of …
Platelet Function And Energy Metabolism During Storage In A Well-Defined Experimental Medium, Thais Edwina Ahrendt Keegan
Platelet Function And Energy Metabolism During Storage In A Well-Defined Experimental Medium, Thais Edwina Ahrendt Keegan
Theses and Dissertations in Biomedical Sciences
The most significant problem in maintaining platelet viability during storage is the decrease in pH resulting from accumulation of lactic acid formed by platelet anaerobic glycolysis. This study investigates nutrient alternatives to glucose for maintenance of morphology and functional integrity during platelet storage in a well-defined synthetic medium and correlates this data with purine nucleotide levels determined by high-performance liquid chromatography (HPLC) and other in vitro measures of platelet quality. Platelets prepared from pooled ABO- and Rh- identical platelet-rich plasma were stored as concentrates in the synthetic medium without added nutrients (control) and with added substrates.
The HPLC procedure developed …
Molecular Study Of The B19 (Human) Pathogenic Parvovirus, Jamshed Ayub
Molecular Study Of The B19 (Human) Pathogenic Parvovirus, Jamshed Ayub
Theses and Dissertations in Biomedical Sciences
The B19 (human) parvovirus is a small single stranded DNA virus of 5.4 kilobases. B19 is specific for erythroid progenitor cells and has been propagated in vitro only with human erythroid bone marrow. Replication of viral DNA and the viral protein products of B19 appear similar to those of other animal parvoviruses. However, B19 differs from other parvoviruses in some important aspects, which include the initiation of all transcripts at a strong left side promoter (p6) and the absence of a functional internal promoter. B19 has an unusual transcription map which is described in this study.
The transcription map of …