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Articles 181 - 207 of 207
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Fidelity Of Dna Polymerase In Vitro, Yannacos C. Philopoulos
Fidelity Of Dna Polymerase In Vitro, Yannacos C. Philopoulos
Dissertations
The fidelity of DNA Polymerase I, isolated from B. licheniformis and B. stearothermophilus, was tested in the presence of carcinogens and anticancer compounds. All of these compounds inhibited (62.4-99.2%) the synthesis of DNA using Poly(dA-dT) as a template. The compounds were inhibitory at all concentration levels tested, 0.01, 1.0 and 100 mM. The fidelity of the enzyme appeared to be enhanced by the presence of these compounds, as indicated by misincorporation (50-70%), that is, the incorporation of incorrect nucleotide. Misincorporation in the presence of either carcinogens or anticancer compounds was less than that of control. The results from both organisms …
Elastin Content Of The Aorta From The Quantitation Of The Desmosines, H. Patrick Covault
Elastin Content Of The Aorta From The Quantitation Of The Desmosines, H. Patrick Covault
Dissertations
No abstract provided.
The Uptake And Release Of Label From Endocytosed 35so4-Labeled Proteins In Cultured Mouse Peritoneal Macrophages, Susan Patterson Buktenica
The Uptake And Release Of Label From Endocytosed 35so4-Labeled Proteins In Cultured Mouse Peritoneal Macrophages, Susan Patterson Buktenica
Dissertations
No abstract provided.
The Effects Of Maternal Protein Deficiency On The Development Of Synaptic Plasma Membranes In Rat Offspring, Duane M. Smith
The Effects Of Maternal Protein Deficiency On The Development Of Synaptic Plasma Membranes In Rat Offspring, Duane M. Smith
Dissertations
No abstract provided.
Iodothyronine 5'-Deiodinase: Solubilization, Partial Purification, And Characterization Of A Thyroxine Deiodinase Extracted From Rat Liver Membranes, Samuel C. Powell
Iodothyronine 5'-Deiodinase: Solubilization, Partial Purification, And Characterization Of A Thyroxine Deiodinase Extracted From Rat Liver Membranes, Samuel C. Powell
Dissertations
No abstract provided.
A Microbial Reductive Conversion Of The Steffimycin Chromophore: Chemical And Mechanistic Studies On A Soluble, Nadhdependent, Nonflavin-Containing Reductase From Streptomyces Steffisburgensis, John Rollin Hofstetter
A Microbial Reductive Conversion Of The Steffimycin Chromophore: Chemical And Mechanistic Studies On A Soluble, Nadhdependent, Nonflavin-Containing Reductase From Streptomyces Steffisburgensis, John Rollin Hofstetter
Dissertations
An understanding of a microbial reduction of the anthracycline antibiotic, steffimycin (1) was approached from two directions. First, the NADH-dependent enzyme responsible for the reduction was purified from the Streptomyces steffisburgensis cytosol and characterized. Second, information was obtained on the reduction and oxidation of 1.
The enzyme was a single polypeptide chain, acidic, and stable in solution. It had a molecular weight of 80,000 and no prosthetic groups.
The 5-step purification process resulted in greater than 1,000-fold purification and a 9% yield of the homogenous enzyme from extracts of S. steffisburgensis cells.
The enzyme reduced 1 by a two-electron mechanism …
Neurochemical Studies On The Metabolism And Effects Of Catecholic Isoquinolines, T. C. Origitano
Neurochemical Studies On The Metabolism And Effects Of Catecholic Isoquinolines, T. C. Origitano
Dissertations
No abstract provided.
Electron Spin Resonance Studies Of Membrane Fluidity Of Normal And Malignant Human Neural Tissues, Robert P. Wersto
Electron Spin Resonance Studies Of Membrane Fluidity Of Normal And Malignant Human Neural Tissues, Robert P. Wersto
Dissertations
No abstract provided.
Thermodynamics Of Association And Catalysis Of N-Acyl-Peptidyl-Phenylalanine Amide Substrates By Chymotrypsin, John Paul Huff
Thermodynamics Of Association And Catalysis Of N-Acyl-Peptidyl-Phenylalanine Amide Substrates By Chymotrypsin, John Paul Huff
Dissertations
No abstract provided.
Acetoacetate Decarboxylase Activity Of Fraction V Human Serum Albumin, Robert Richard Rosecrans
Acetoacetate Decarboxylase Activity Of Fraction V Human Serum Albumin, Robert Richard Rosecrans
Dissertations
No abstract provided.
The Role Of Skin Temperature In The Control Of Sweating In Man, Thomas V. Mccaffrey
The Role Of Skin Temperature In The Control Of Sweating In Man, Thomas V. Mccaffrey
Dissertations
No abstract provided.
Immuno- And Bioassayable Extrapituitary Growth Hormone And Thyroid Stimulating Hormone From Discrete Areas Of The Central Nervous System, Sally Ann Hojvat
Immuno- And Bioassayable Extrapituitary Growth Hormone And Thyroid Stimulating Hormone From Discrete Areas Of The Central Nervous System, Sally Ann Hojvat
Dissertations
No abstract provided.
Associations Of N-Acyl Amino Aldehyde Analogs Of Specific Substrates To The Active Site Of Chymotrypsin, William P. Kennedy
Associations Of N-Acyl Amino Aldehyde Analogs Of Specific Substrates To The Active Site Of Chymotrypsin, William P. Kennedy
Dissertations
No abstract provided.
Dna Replication In Mesophilic And Thermophilic Bacteria, Pawan K. Gupta
Dna Replication In Mesophilic And Thermophilic Bacteria, Pawan K. Gupta
Dissertations
No abstract provided.
The Interaction Of Thioxanthenones With Nucleic Acids, Laszlo Bodoni
The Interaction Of Thioxanthenones With Nucleic Acids, Laszlo Bodoni
Dissertations
No abstract provided.
The Metabolism Of Linolenic Acid In Developing Rat Brain, Barney E. Dwyer
The Metabolism Of Linolenic Acid In Developing Rat Brain, Barney E. Dwyer
Dissertations
No abstract provided.
Aluminum Metabolism In Health And Disease, Jay Eliot Gorsky
Aluminum Metabolism In Health And Disease, Jay Eliot Gorsky
Dissertations
No abstract provided.
Evidence For Chromium-Insulin Interaction, Ronald Belusko
Evidence For Chromium-Insulin Interaction, Ronald Belusko
Dissertations
No abstract provided.
Changes In Morphology And Protein Content Of Neurons And Glia Of The Developing Hamster Cerebral Cortex, Thomas E. Durica
Changes In Morphology And Protein Content Of Neurons And Glia Of The Developing Hamster Cerebral Cortex, Thomas E. Durica
Dissertations
No abstract provided.
Studies On The Mechanism Of Inhibition Of Rna Synthesis By Template Inactivators, Nikos Panayotatos
Studies On The Mechanism Of Inhibition Of Rna Synthesis By Template Inactivators, Nikos Panayotatos
Dissertations
No abstract provided.
The Interaction Of Phenanthridinium Derivatives With Nucleic Acids, Antonis Kindelis
The Interaction Of Phenanthridinium Derivatives With Nucleic Acids, Antonis Kindelis
Dissertations
No abstract provided.
Interaction Of Lung Surfactant Lipids With Proteins Of The Alveolar Space, Peter Pagast
Interaction Of Lung Surfactant Lipids With Proteins Of The Alveolar Space, Peter Pagast
Dissertations
No abstract provided.
Studies Of The Effects Of Solvent Composition On The Association-Dissociation Of Oxyhemerythrin As Determined By Analytical Gel Chromatography, Kim Hock Tan
Dissertations
No abstract provided.
Polysomes From Mesophilic And Thermophilic Bacteria, Philip Y. Shen
Polysomes From Mesophilic And Thermophilic Bacteria, Philip Y. Shen
Dissertations
No abstract provided.
Purification And Properties Of Phenylalanine Transfer Rna From Bacillus Licheniformis And Bacillus Stearothermophilus, Cynthia R.Y. Yang
Purification And Properties Of Phenylalanine Transfer Rna From Bacillus Licheniformis And Bacillus Stearothermophilus, Cynthia R.Y. Yang
Dissertations
No abstract provided.
A Study Of Glycosphingolipids In Aorta, Blood And Spleen And The Effects Of Atherogenic Diets On These Lipids In Rabbits, Eric Coles
Dissertations
No abstract provided.
Purification And Properties Of Dna Polymerase From Bacillus Licheniformis And Bacillus Stearothermophilus, Bruce A. Roe
Purification And Properties Of Dna Polymerase From Bacillus Licheniformis And Bacillus Stearothermophilus, Bruce A. Roe
Dissertations
No abstract provided.