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Articles 1 - 4 of 4
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Examining The Ph Switch Of Copper-Zinc Superoxide Dismutase Mutant A4v, Ty Jungman
Examining The Ph Switch Of Copper-Zinc Superoxide Dismutase Mutant A4v, Ty Jungman
Honors Program Theses and Research Projects
Amyotrophic lateral sclerosis(ALS) is a neurodegenerative disease that causes progressive loss to motor neurons. Buildup of superoxide anions (O2-) and aggregation of superoxide dismutase (SOD) is thought to be probable causes of damage to the neurons. This damage results in the progressive loss of function in the neurons resulting in flaccid paralysis. Superoxide anions were originally thought to cause irreparable damage to the motor neurons; however, recent studies have shown that the aggregation of SOD causes damage to the cell. Furthermore, the ability for the SOD1 to get metalated to dissuade aggregation has become an important topic of study in …
Feasibility Of Tubulin As A Control For Gene Expression Following Transfection In Mouse Monocyte/Macrophage-Like Cells, Ankita Chabra
Feasibility Of Tubulin As A Control For Gene Expression Following Transfection In Mouse Monocyte/Macrophage-Like Cells, Ankita Chabra
Honors Program Theses and Research Projects
Transfection, which is the ability to modify host cells’ genetic content, has broad application in studying normal cellular processes, molecular mechanism of disease and gene therapy. There are several transfection techniques, and all require either a control or a reference gene. Commonly used controls for transfection experiments are housekeeping genes, which maintain expression for a given cell/tissue, experimental conditions, and treatment. However, recent research has uncovered that expression levels of housekeeping genes may vary depending on the gene, cell type and experimental conditions. A growing body of evidence demonstrates that housekeeping genes are inadequate internal standards for measuring gene expression …
Rosalind Elsie Franklin (1920-1958) Biologist, Margaret Sylvia
Rosalind Elsie Franklin (1920-1958) Biologist, Margaret Sylvia
Faculty Publications
A biography of the biologist Rosalind Elsie Franklin whose work on x-ray crystallography contributed to Watson and Crick's elucidation of the structure of DNA.
Rosalyn Sussman Yalow (1921-) Endocrinologist, Medical Physicist, Margaret Sylvia
Rosalyn Sussman Yalow (1921-) Endocrinologist, Medical Physicist, Margaret Sylvia
Faculty Publications
A biography of Rosalyn Yalow, Nobel Prize winner in Physiology/Medicine for the development of radioimmunoassay of peptides hormones. She was the second woman to win a Nobel Prize in Medicine and first American woman to do so.