Other Animal Sciences Commons^™

Maternal Hyperleptinemia Alters Placental Transcriptome And Progesterone Regulation Without Affecting Early Equine Fetal Growth, Lucinda L. Thorburn

LSU Master's Theses

While consequences of equine obesity are well defined, the extent to which persistent hyperleptinemia and accompanying leptin (Lep) resistance affect the fetal-maternal environment warrants further exploration. This study compared endocrine, fetal, placental, and uterine parameters during early pregnancy (through day 70) in mares with elevated leptin versus normal leptin (NL) concentrations. Fourteen mares were classified as either NL (n = 6; Lep 0.9 ± 0.3 ng/mL), moderate leptin (ML; n = 4; Lep 3.0 ± 0.3 ng/mL), or high leptin (HL; n = 4; Lep 5.8 ± 0.7 ng/mL) based on annual plasma leptin. Mares were artificially inseminated and induced …

The Design, Construction, And Testing Of Nucleic Acid Vaccines Against Salmonella Enterica Subspecies Enterica Serovar Javiana, Alexis A. Nguyen

LSU Master's Theses

Salmonella spp. is a Gram-negative bacterium that has the ability to replicate within a variety of hosts, or within the environment, including water, soil, and vegetation. These characteristics, coupled with the zoonotic nature of non-typhoidal Salmonella, pose a significant public health concern. Salmonella is the leading cause of foodborne illnesses worldwide, and in the United States alone, the economic impact due to non-typhoidal Salmonella illnesses in 2013 was estimated to be $3.7 billion, the majority of which were due to mortalities. In a time of rising antibiotic resistance, antibiotics are no longer considered the most effective treatment for …

Morphological And Molecular Characterization Of The Olfactory System In The Formosan Subterranean Termite, Paula Castillo

LSU Doctoral Dissertations

The Formosan subterranean termite, Coptotermes formosanus, is a eusocial insect species. Its members live in colonies consisting of reproductive (queen and king) and non-reproductive individuals (workers and soldiers). Olfaction is an essential sense for the social life of many insects. However, in termites, little is known about how olfactory cues are perceived in the peripheral sensory system (antennae) and processed in the central nervous system (brain) to elicit different behavioral responses across castes. In this study, we investigated the olfactory system in all castes (soldiers, workers, and reproductive alates), from the antennal and brain morphology to the antennal gene …

Gain-Of-Function Polymorphisms In Human Inflammasomes: Implications For Cystic Fibrosis, Duane Jeansonne, Samithamby Jeyaseelan

Faculty Publications

No abstract provided.

Sexually Dimorphic Oxytocin Receptor-Expressing Neurons In The Anteroventral Periventricular Nucleus Regulates Maternal Behavior, Kaustubh Sharma

LSU Doctoral Dissertations

The neurohypophysial hormone oxytocin is involved in the regulation of social behaviors, including social recognition, pair bonding, and sex-specific parental behaviors in a variety of species. Oxytocin triggers these social behaviors by binding to oxytocin receptors (OXTR) in various parts of the brain. Oxytocin-induced sex-typical behavior, therefore, suggests a sexual dimorphic distribution of OXTR in the brain. In recent years, the oxytocin system in the brain received tremendous attention as a potential pharmacological target for treatment of many psychiatric disorders, such as anxiety, autism spectrum disorders, and even sex-specific psychiatric disorder like postpartum depression (PPD). An important problem and a …

Artificial Intelligence And Covid-19: Deep Learning Approaches For Diagnosis And Treatment, M. B. Jamshidi, A. Lalbakhsh, J. Talla, Z. Peroutka, F. Hadjilooei, P Lalbakhsh, M. Jamshidi, L. La Spada, M. Mirmozafari, M. Dehghani, A. Sabet, Sa. Roshani, So. Roshani, N. Bayat-Makou, B. Mohamadzade, Z. Malek, A. Jamshidi, S. Kiani, H. Hashemi-Dezaki, W. Mohyuddin

Faculty Publications

COVID-19 outbreak has put the whole world in an unprecedented difficult situation bringing life around the world to a frightening halt and claiming thousands of lives. Due to COVID-19 & x2019;s spread in 212 countries and territories and increasing numbers of infected cases and death tolls mounting to 5,212,172 and 334,915 (as of May 22 2020), it remains a real threat to the public health system. This paper renders a response to combat the virus through Artificial Intelligence (AI). Some Deep Learning (DL) methods have been illustrated to reach this goal, including Generative Adversarial Networks (GANs), Extreme Learning Machine (ELM), …

Evaluation Of Reproductive Phenology And Ecology Of Wild Turkey (Meleagris Gallopavo) Across The Southeastern United States, Landon Robert Schofield

LSU Master's Theses

The primary driver of population growth and sustainability of gallinaceous birds is annual recruitment. Habitat selection by wild turkeys (Meleagris gallopavo spp.) during reproductive activities could influence production at multiple temporal and spatial scales. Vegetation conditions at nest sites that could drive nest success have not been clearly identified, which suggests that other factors may drive reproductive success.

Female wild turkeys maintain dominance hierarchies, which could influence how reproductively active females distribute themselves across the landscape during reproductive periods. Using high-frequency GPS data collected from reproductively active females, I analyzed nesting attempts for Eastern (n = 381), …

Characterizing Cytoplasmic Maturation And Improving Competence Of Bovine In Vitro Matured Oocytes, Brittany Alanna Foster

LSU Doctoral Dissertations

As the necessity to improve in vitro embryo production efficiency is ever increasing, so too is the prerequisite obligation to improve oocyte competence. The ability of an oocyte to successfully produce a viable embryo requires that it both completes meiotic maturation and synchronously achieves cytoplasmic competence; an encompassing term that refers to the oocytes correct accumulation and storage of mRNAs, proteins and factors as well as the development and reorganization of organelles and the cytoskeleton. The current research was designed to analyze those methods that go into oocyte collection and pre-maturation handling to determine if there are ways to ensure …

Evaluation Of Dopaminergic And Antidopaminergic Agents For Use In Equine Metabolic Physiology, Nicole Arana Valencia

LSU Doctoral Dissertations

A series of experiments studied the effects and practical applications of dopaminergic and antidopaminergic compounds in equine metabolic physiology. The first experiment was performed to assess the long-term effects of repeated cabergoline injections (every 10 days for a total of seven injections) on prolactin and α-melanocyte stimulating hormone concentrations in insulin insensitive mares. Additionally, the experiment also evaluated the use of cabergoline for improving insulin sensitivity. Plasma prolactin and α-melanocyte stimulating hormone concentrations were suppressed throughout the duration of the experiment even when the mares were challenged with a low-dose dopamine antagonist, sulpiride, the day previous to their subsequent cabergoline …

An Examination Of Preimplantation Embryos And Endometrium Developed During Induced Aluteal Cycles In The Mare, Chelsey Audra Leisinger

LSU Doctoral Dissertations

Changes to the embryonic environment that occur within the first few days of development can have significant effects on subsequent fetal development. The following studies investigate the effects of progesterone-deprivation during the early preimplantation period in the mare. The first study described embryo morphology (diameter, stage, and quality grade) collected from mares with induced aluteal cycles. The second study evaluated the effect of induced aluteal cycles on the future fertility of embryo collections as a potential method for cycle manipulation of embryo donor mares. The third study characterized embryonic and endometrial transcript expression of progesterone-mediated transcripts as well as those …

Evaluation Of Reproductive Phenology And Ecology Of Eastern Wild Turkey (Meleagris Gallopavo Silvestris) In South Carolina, Patrick Wightman

LSU Master's Theses

Many southeastern states, including South Carolina, in the last 10 -15 years have seen a decline in Eastern wild turkey (Meleagris gallopavo silvestris) populations. Around 50,000 turkey hunters in South Carolina, result in approximately 35 million annually in revenue. Turkeys encounter a unique situation as environmental variation and hunter activity may impact behaviors as hunting occurs during the reproductive season. Mistimed hunting seasons could result in population declines. Timing of harvest requires managers to implement seasons that allow for hunter satisfaction (hearing gobbles) while ensuring no detriment to turkey populations through impacts to reproduction. To better understand factors influencing gobbling …

Failure Of A Heterologous Recombinant Sca5/Ompb Protein-Based Vaccine To Elicit Effective Protective Immunity Against Rickettsia Rickettsii Infections In C3h/Hen Mice, Sean P. Riley, Marissa M. Cardwell, Yvonne G. Chan, Ludovic Pruneau, Fabio Del Piero, Juan J. Martinez

Faculty Publications

Spotted fever group (SFG) rickettsial species are obligate intracellular tick-borne pathogens that are responsible for important human diseases. Previous reports have demonstrated the feasibility of using recombinant surface cell antigen Sca5/OmpB to elicit protective immunity against homologous challenges using murine models of Mediterranean spotted fever and Rocky Mountain spotted fever. In addition, the feasibility of generating cross-protective immunity against related rickettsial species has also been established, but the molecular basis for these phenomena was not explored. Here, we demonstrate that vaccination of C3H/HeN mice with a recombinant OmpB domain derived from Rickettsia conorii induced high titer humoral immune responses that …