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Full-Text Articles in Dairy Science
Evaluation Of Immunomodulators, Interferons And Known In Vitro Sars-Cov Inhibitors For Inhibition Of Sars-Cov Replication In Balb/C Mice, Dale L. Barnard, C. W. Day, K. Bailey, M. Heiner, R. Montgomery, L. Lauridsen, P. K-S. Chan, R. W. Sidwell
Evaluation Of Immunomodulators, Interferons And Known In Vitro Sars-Cov Inhibitors For Inhibition Of Sars-Cov Replication In Balb/C Mice, Dale L. Barnard, C. W. Day, K. Bailey, M. Heiner, R. Montgomery, L. Lauridsen, P. K-S. Chan, R. W. Sidwell
Animal, Dairy, and Veterinary Science Faculty Publications
Compounds approved for therapeutic use and in vitro inhibitors of severe acute respiratory syndrome coronavirus (SARS-CoV) were evaluated for inhibition in the mouse SARS-CoV replication model. A hybrid interferon, interferon alpha (IFN-alpha) B/D, and a mismatched double-stranded (ds) RNA interferon (IFN) inducer, Ampligen® (poly I:poly C124), were the only compounds that potently inhibited virus titres in the lungs of infected mice as assessed by CPE titration assays. When mice were dosed intraperitoneally (i.p.) with IFN-alpha B/D once daily for 3 days beginning 4 h after virus exposure, SARS-CoV replication in the lungs of infected mice was reduced by 1 log10 …