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Topical Cidofovir Is More Effective Than Is Parenteral Therapy For Treatment Of Progressive Vaccinia In Immunocompromised Mice, Donald F. Smee, K. W. Bailey, M-H. Wong, M. K. Wandersee, R. W. Sidwell
Topical Cidofovir Is More Effective Than Is Parenteral Therapy For Treatment Of Progressive Vaccinia In Immunocompromised Mice, Donald F. Smee, K. W. Bailey, M-H. Wong, M. K. Wandersee, R. W. Sidwell
Animal, Dairy, and Veterinary Science Faculty Publications
Background.Severe complications may arise as a result of virus dissemination after smallpox (live vaccinia virus) vaccination, particularly in immunocompromised individuals. We developed a new mouse model for studying the effects of antiviral agents on progressive vaccinia virus infections.
Methods.Hairless mice were treated with cyclophosphamide (100 mg/kg/day) every 4 days starting 1 day before vaccinia virus exposure to wounded skin. Primary lesions progressed in severity, satellite lesions developed, and the infection eventually killed the mice.
Results.Topical treatment with 1%‐cidofovir cream (twice daily for 7 days) was much more effective in reducing the severity of primary lesions and the number of satellite …